Researchers develop a rapid method for building vascular organoids

This system offers a powerful new platform for vascular network modeling, tissue engineering, and regenerative medicine

2025-06-13

(Press-News.org) Blood vessels are essential to nearly all tissues, delivering nutrients and oxygen, regulating hemostasis, and modulating inflammation. Recreating functional vascular networks is foundational to both basic and translational vascular biology, however current methods to make blood vessels from stem cells are often slow, inefficient, or lack the complexity needed for therapy.

In this study, researchers developed a fast and defined method to build vascular organoids—3D microvascular networks—from human stem cells. By precisely activating two transcription factors (ETV2 and NKX3.1), they were able to drive the formation of both endothelial and mural cells simultaneously. This resulted in self-assembling, functional vessels that can connect to host vasculature when implanted.

This approach not only accelerates the process of building blood vessels but—critically—achieves full, independent control over the two major vascular cell types needed to build functional blood vessels. This level of control has not been previously demonstrated in other models. As a result, this system offers a powerful new platform for vascular network modeling, tissue engineering, and regenerative medicine.

END

ELSE PRESS RELEASES FROM THIS DATE:

Cannabis legalization and opioid use disorder in Veterans Health Administration patients

2025-06-13

About The Study: The results of this cohort study suggest that medical cannabis laws and recreational cannabis laws enactment was associated with greater opioid use disorder (OUD) prevalence in Veterans Health Administration patients over time, with the greatest increases among middle-aged and older patients and those with chronic pain. The findings did not support state cannabis legalization as a means of reducing the burden of OUD during the ongoing opioid epidemic. Corresponding Author: To contact the corresponding author, Deborah S. Hasin, PhD, email dsh2@cumc.columbia.edu. To access the embargoed study: Visit our For The Media website at this link ...

Volume and intensity of walking and risk of chronic low back pain

2025-06-13

About The Study: In this cohort study, daily walking volume and walking intensity were inversely associated with the risk of chronic low back pain. The findings suggest that walking volume may have a more pronounced benefit than walking intensity. Corresponding Author: To contact the corresponding author, Rayane Haddadj, MS, email rayane.haddadj@ntnu.no. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.15592) Editor’s Note: Please see ...

New cooling tech could curb data centers' rising energy demands

2025-06-13

Engineers at the University of California San Diego have developed a new cooling technology that could significantly improve the energy efficiency of data centers and high-powered electronics. The technology features a specially engineered fiber membrane that passively removes heat through evaporation. It offers a promising alternative to traditional cooling systems like fans, heat sinks and liquid pumps. It could also reduce the water use associated with many current cooling systems. The advance is detailed in a paper published on June 13 in the journal Joule. As artificial intelligence (AI) and cloud computing continue to expand, the demand for data processing—and ...

First quantum-mechanical model of quasicrystals reveals why they exist

2025-06-13

Photos A rare and bewildering intermediate between crystal and glass can be the most stable arrangement for some combinations of atoms, according to a study from the University of Michigan. The findings come from the first quantum-mechanical simulations of quasicrystals—a type of solid that scientists once thought couldn't exist. While the atoms in quasicrystals are arranged in a lattice, as in a crystal, the pattern of atoms doesn't repeat like it does in conventional crystals. The new simulation method suggests quasicrystals—like crystals—are fundamentally ...

Cardiovascular disease and diabetes are driving the increase in us excess mortality—and adults without college degrees are bearing most of the burden

2025-06-13

About 525,000 more deaths occurred among US adults in 2023 than would be expected had pre-2010 mortality trends continued. More than 90 percent of these deaths occurred among individuals without a Bachelor's degree and were largely caused by cardiovascular diseases, underscoring how educational attainment can influence individuals’ health opportunities and outcomes. Cardiometabolic diseases such as cardiovascular disease and type 2 diabetes have emerged as some of the key drivers of worsening mortality rates in the United States over the last ...

Diagnostic value of GeneXpert MTB/RIF in bronchoalveolar lavage fluid for pulmonary non-tuberculosis mycobacterial in acid-fast stain smear-positive and GeneXpert MTB/RIF-negative cases

2025-06-13

Background: The identification of non-tuberculosis (TB) mycobacterial (NTM) infection remains a significant challenge. This study aims to investigate the diagnostic value of multicolour nested real-time fluorescence quantitative nucleic acid amplification detection technology [Xpert Mycobacterium tuberculosis (MTB)/rifampicin (RIF)] in bronchoalveolar lavage fluid (BALF) acid-fast smear-positive cases. Methods: Between 1 January 2017 and 30 June 2022, 365 patients who underwent fibreoptic bronchoscopy and had positive acid-fast ...

BGI Genomics successfully concludes first Southeast Asia training workshop

2025-06-13

BGI Genomics has successfully wrapped up its inaugural Whole Exome Sequencing (WES) Interpretation of Genetic Diseases Training Workshop for Southeast Asia, marking a significant milestone in international genomics education. Held at the BGI Center in late May, the workshop brought together emerging healthcare professionals and researchers from Thailand, Indonesia, and Vietnam for a week of intensive, hands-on learning. Comprehensive Learning Curriculum The program aimed to improve genetic disease diagnosis in Southeast Asia. It offered both theoretical lessons and hands-on ...

Rare ovarian tumor discovered during postmenopausal vault prolapse evaluation

2025-06-13

“The incidental discovery of a pure SCT in an atrophic ovary during pelvic surgery in a postmenopausal woman is exceedingly rare.” BUFFALO, NY — June 13, 2025 — A new case report was published in Volume 12 of Oncoscience on May 22, 2025, titled “A rare case: Pure Sertoli cell tumor uncovered in atrophic ovary during postmenopausal vault prolapse evaluation.” In this case report, corresponding author Naina Kumar from the All India Institute of Medical Sciences and team describe a ...

Innovative algorithm revolutionizes chip placement for advanced circuit design

2025-06-13

In the fast-paced realm of semiconductor technology, optimizing chip design to meet the dual challenges of performance enhancement and cost reduction has emerged as a pivotal focus. A new study published in Engineering introduces a groundbreaking approach to address this challenge, presenting an exact algorithm for placement optimization in mixed-cell-height (MCH) circuits. Led by researchers Binqi Zhang, Lu Zhen, and Gilbert Laporte, the work tackles the intricate task of arranging diverse circuit cells within constrained chip regions while adhering to critical design rules, including ...

Hereditary mutations in BRCA genes increase risk of rare lymphoma among women with breast cancer who received textured breast implants

2025-06-13

(WASHINGTON, June 13, 2025) – Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more likely to develop breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a rare T-cell lymphoma, compared with similar women without these genetic mutations, according to a study published today in Blood Advances. “Our findings show that BRCA1 and BRCA2 mutations are a significant risk factor for developing this type of lymphoma, confirming earlier suggestions of a possible role. It’s possible ...