A small reaction space has a big impact on polymer chemistry

(Press-News.org) Tokyo, Japan – Mimicking the incredible skill of mother nature is never easy, especially when trying to match the remarkable chemical processes that take place in living organisms. Living systems, like cells, can carry out chemical reactions in very small spaces, sometimes involving single molecules. For many years, researchers have attempted to emulate this to allow for the manufacturing of specialized chemical compounds, but with limited success.

However, new research published in the Journal of the American Chemical Society highlights the development of a new tool that assists with controlling chemical reactions. This could allow important polymers – the large, chainlike molecules with many modern applications – to be created in incredibly small spaces with a high level of precision.

The team, based at the Institute of Industrial Science, The University of Tokyo, developed a ‘molecular flask’ – which modulates the reactivity of the reactions happening in its interior – using a carefully constructed single polymer molecule with a unique shape.

“Previous work in this field has created small molecular reactors based on various porous materials,” says lead author, Xiangyuan Guo. “However, it is difficult to use these processes to make specific polymers, because the polymerization reaction is not easily controlled.”

This new work created polymers based on central, wormlike molecules with many protruding side chains, known as a ‘bottlebrush’ shape. The side chains act to produce a kind of internal buffer zone that allows some substances to enter the space around the body of the polymer molecule, while keeping others out.

This zone can be as small as a single molecule and can be tailored to provide adequate space for the formation of other polymers. Inside these nanosized pockets, chemicals can react to produce only certain desired products, protected from the effects of their surroundings. For this reason, materials that are otherwise difficult to synthesize can be obtained using this system.

“One of the main advantages of this new process is that it is extremely versatile,” explains senior author, Shintaro Nakagawa. “This was demonstrated by synthesizing two completely different types of polymers, including a specialized conjugated polymer based on thiophene with applications in optoelectronics.”

The spaces inside these carefully designed bottlebrush polymers are extremely small: on the order of tens of nanometers, meaning billionths of a meter. Similar to biological systems such as enzymes, these molecular-scale flasks allow an extreme level of control of chemical reactions.

In addition to making specialty polymers with many different applications, this breakthrough technology could someday be employed to produce nanoparticles and other materials with applications in medicine, sensing technology and other fields.

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The article, “Single-molecule reactor based on the excluded volume effect of bottlebrush polymers,” was published in the Journal of the American Chemical Society, DOI: <a href="https://doi.org/10.1021/jacs.5c06532" target="_blank">10.1021/jacs.5c06532</a>

 

About Institute of Industrial Science, The University of Tokyo The Institute of Industrial Science, The University of Tokyo (UTokyo-IIS) is one of the largest university-attached research institutes in Japan. UTokyo-IIS is comprised of over 120 research laboratories—each headed by a faculty member—and has over 1,200 members (approximately 400 staff and 800 students) actively engaged in education and research. Its activities cover almost all areas of engineering. Since its foundation in 1949, UTokyo-IIS has worked to bridge the huge gaps that exist between academic disciplines and real-world applications.
 

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