Verify the therapeutic effect of effective components of lycium barbarum on hepatocellular carcinoma based on molecular docking
2025-06-27
(Press-News.org) Background and objectives
In recent years, it has been found that Lycium barbarum can repair liver damage and promote liver regeneration. Additionally, the polysaccharides contained in Lycium barbarum have anticancer properties and can induce apoptosis in cancer cells. Molecular docking, a mature computer-aided method, is widely used in drug discovery. This study aimed to verify the efficacy of active ingredients of Lycium barbarum in the treatment of liver cancer by molecular docking.
Methods
The effect of the active ingredients of Lycium barbarum in the treatment of liver cancer was verified by molecular docking, based on a previous study that examined the impact of Lycium barbarum on liver cancer using network pharmacology.
Results
The binding energies of the key active ingredients and core targets were all less than −5.0 kcal/mol (1 kcal = 4.184 J), with most of them being less than −7.0 kcal/mol. This indicates that the key active ingredients and core targets have good binding ability, with most demonstrating strong binding affinity.
Conclusions
This study confirms that Lycium barbarum contains multiple components that play a role in the treatment of liver cancer. It also interacts with multiple targets and pathways through molecular docking and a basic analysis of previous studies, suggesting that the Chinese medicine Lycium barbarum acts in the treatment of liver cancer through various components and pathways, providing new insights for the clinical treatment of liver cancer.
Full text
https://www.xiahepublishing.com/2996-3427/OnA-2025-00003
The study was recently published in the Oncology Advances.
Oncology Advances is dedicated to improving the diagnosis and treatment of human malignancies, advancing the understanding of molecular mechanisms underlying oncogenesis, and promoting translation from bench to bedside of oncological sciences. The aim of Oncology Advances is to publish peer-reviewed, high-quality articles in all aspects of translational and clinical studies on human cancers, as well as cutting-edge preclinical and clinical research of novel cancer therapies.
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[Press-News.org] Verify the therapeutic effect of effective components of lycium barbarum on hepatocellular carcinoma based on molecular docking
