(Press-News.org) Anaerobic bacteria – masters of survival without oxygen
Anaerobic bacteria were among the first life forms on earth and existed at a time when there was no oxygen in the atmosphere. While many organisms depend on an oxygen-rich environment to survive, anaerobes thrive in places where others cannot – in completely oxygen-free habitats such as the human gut or the ocean floor. The enzymes of these bacteria are even sensitive to oxygen. Their remarkable adaptability is increasingly attracting the attention of researchers.
Anaerobic bacteria often produce unusual substances. This makes them particularly interesting for research and biotechnology, for example for the production of antibiotics or biofuels. They are also indispensable players in the natural nutrient cycle by breaking down organic material such as cellulose and releasing nutrients back into the ecosystem.
A signal substance with a key role
Clostridium thermocellum is one of the best-known anaerobic microbes when it comes to the degradation of cellulose – the main component of plant cell walls. It converts cellulose into sugar, which can then be used to produce biofuels such as ethanol. A conspicuous yellow pigment produced by the bacterium (YAS – Yellow Affinity Substance) plays a key role in this process. YAS preferentially attaches itself to cellulose fibers. It is assumed that YAS helps to direct the degrading enzymes precisely to where cellulose is present.
Structural analysis of bacterial pigments
Researchers at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI) and the Max Planck Institute for Chemical Ecology in Jena have now succeeded for the first time in elucidating the molecular composition of YAS. The scientists discovered that YAS consists of several components, so-called celluxanthenes, and determined their molecular structures using spectroscopic analyses (NMR, MS) and isotope labeling experiments. In addition, they identified the biosynthetic gene cluster responsible through targeted genetic manipulation.
A pigment with medical potential?
Surprisingly, the pigments show an effect against certain microorganisms. The celluxanthenes have mild antibiotic activity against Gram-positive bacteria – including clinically relevant, resistant pathogens. Understanding the genetic basis of biosynthesis also opens up the possibility of producing or modifying celluxanthenes in the future. First authors Keishi Ishida and Jana Krabbe see promising results: “Although the yellow pigments have been known for almost a century, their structure has remained a mystery until now. We can now begin to investigate possible ecological functions, including antibacterial activity to defend the food source (cellulose) against competitors.”
A step towards a sustainable future
The discovery and characterization of celluxanthenes bridges the gap between our understanding of microbial metabolism and practical applications in the energy sector – and perhaps in future medical research. The findings could also help to optimize the use of plant biomass.
The research is part of the “AnoxyGen” project, for which Christian Hertweck was awarded one of the prestigious ERC Advanced Grants from the European Research Council. Hertweck is head of department at the Leibniz-HKI and professor at the Friedrich Schiller University Jena. “AnoxyGen aims to unlock the hidden potential of anaerobic bacteria to produce new bioactive natural products,” explains Hertweck. “Many of these microorganisms carry genes in their genome for the production of valuable compounds, but these usually remain inactive under standard laboratory conditions.” The team is developing new molecular biological methods to activate these hidden biosynthetic pathways – methods that previously existed mainly for aerobic (oxygen-dependent) microbes. The aim is to discover and harness previously unknown natural substances with medical or biotechnological value. AnoxyGen combines modern synthetic biology with the discovery of active substances and could open up new possibilities for pharmaceutical development.
The AnoxyGen project also contributes to the Cluster of Excellence “Balance of the Microverse”, which investigates the complex signaling and communication mechanisms within microbial communities that govern life on Earth.
END
Pigments that can do more
New discovery sheds light on the bacterial use of biomass with potential for biofuels and new antibiotics
2025-06-30
ELSE PRESS RELEASES FROM THIS DATE:
How to refocus in the age of distraction
2025-06-30
COLUMBUS, Ohio – Studies show that the average attention span is now only eight seconds. That’s about as much time as it takes to read a few sentences before being distracted.
A new national survey of 1,000 American adults commissioned by The Ohio State University Wexner Medical Center and College of Medicine finds that stress and anxiety contribute most to a short attention span (43%), followed by lack of sleep (39%) and digital devices (35%).
Other contributing factors include boredom or lack of interest (31%); multitasking (23%); lack of physical activity (21%); poor diet/hydration (20%) and medical conditions such as ADHD ...
The rise of 'artificial historians': AI as humanity’s record-keeper
2025-06-29
In documenting and recording society’s collective data on an unprecedented scale, artificial intelligence is becoming humanity’s historian – changing the way we record information for posterity.
But AI’s inadvertent role as memory-keeper raises profound concerns for today’s historians. Unlike human historians who explicitly document their methodologies, AI systems are creating the historical archives of the future without crucial transparency around how sources are selected, weighted, and interpreted.
This undermines a fundamental principle of historical scholarship, that methodologies should be visible and contestable. In the new book ...
Older paternal age linked to higher miscarriage risk and lower live birth rates in donor egg IVF cycles, new study finds
2025-06-29
(Paris, France, Monday, 30 June 2025) A new international study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that IVF cycles involving male partners over the age of 45 carry significantly increased miscarriage risks and lower live birth rates – even when young donor eggs are used.[1]
By isolating paternal age from female reproductive factors through the exclusive use of donor eggs from young women, the study provides robust evidence that male age plays a critical role in reproductive success, challenging the common assumption ...
New study provides breakthrough in pig-to-human kidney transplantation
2025-06-29
(Monday 30 June 2025, London, United Kingdom) A pioneering study has provided unprecedented insights into the immune response following pig-to-human kidney xenotransplantation.1
The findings, presented today at the ESOT Congress 2025, mark a significant step forward in overcoming the biggest challenge in xenotransplantation: rejection by the human immune system.
Using cutting-edge spatial molecular imaging, researchers mapped how human immune cells interact with pig kidney tissue in transplanted organs, revealing critical ...
Gut bacteria and amino acid imbalance linked to higher miscarriage risk in women with PCOS
2025-06-29
(Paris, France, Monday, 30 June 2025) A new study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that women with polycystic ovary syndrome (PCOS) have distinct gut microbiota and metabolic signatures linked to premature endometrial ageing and a higher risk of adverse pregnancy outcomes.[1]
The research highlights a sharp reduction in the beneficial gut bacterium Parabacteroides merdae (P. merdae), alongside elevated levels of branched-chain amino ...
Simple blood test detects preeclampsia risk months before symptoms appear, new study shows
2025-06-29
(Paris, France, Monday, 30 June 2025) A simple blood test taken in the first trimester of pregnancy could accurately identify women at risk of developing preeclampsia five months before clinical diagnosis, according to new research presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE).[1]
Using a cell-free RNA (cfRNA) “liquid biopsy” of maternal plasma, researchers at the Carlos Simon Foundation and iPremom enrolled 9,586 pregnant women from 14 hospitals across Spain between September 2021 and June 2024. In a nested case-control analysis of 216 participants, they successfully predicted both early-onset and late-onset ...
3D printing breakthrough: Scientists create functional human islets for type 1 diabetes treatment
2025-06-28
(Monday, 30 June 2025, London, United Kingdom) A team of international scientists has made a major leap forward in diabetes research by successfully 3D printing functional human islets using a novel bioink. Presented today at the ESOT Congress 2025, the new technology could pave the way for more effective and less invasive treatment options for people living with type 1 diabetes (T1D).1
The breakthrough involved printing human islets – the insulin-producing clusters of cells in the pancreas – using a customised bioink made from alginate and decellularised human pancreatic tissue. This approach produced durable, high-density islet structures that remained alive and functional ...
Malnutrition in children rises when economy drops
2025-06-27
Even small drops in national income can significantly increase the risk of various forms of childhood malnutrition- not only undernutrition but also overweight and obesity, shows a study led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation. The study, published in Lancet Global Health, identifies pregnancy and the first 1,000 days of life as especially vulnerable periods where targeted interventions can make a big difference.
One in four children worldwide lives in severe food poverty. And many low- and middle-income countries ...
New model enables the study of how protein complex influences mitochondrial function
2025-06-27
A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating the interaction between the proteasome and mitochondrial function. In eukaryotic cells, the proteasome is a protein complex responsible for eliminating damaged and nonfunctional proteins, thereby helping to maintain cellular balance and proper functioning.
In recent years, studies have revealed that the proteasome ...
Device study offers hopes for spinal cord injuries
2025-06-27
Spinal cord injuries are currently incurable with devastating effects on people’s lives, but now a trial at Waipapa Taumata Rau, University of Auckland offers hope for an effective treatment.
Spinal cord injuries shatter the signal between the brain and body, often resulting in a loss of function.“Unlike a cut on the skin, which typically heals on its own, the spinal cord does not regenerate effectively, making these injuries devastating and currently incurable,” says lead researcher Dr Bruce Harland, a senior research fellow in the School of Pharmacy at Waipapa Taumata Rau, University of Auckland.
Before birth, and to a lesser extent afterwards, ...
LAST 30 PRESS RELEASES:
Transcatheter or surgical treatment of patients with aortic stenosis at low to intermediate risk
Promising new drug for people with stubborn high blood pressure
One shot of RSV vaccine effective against hospitalization in older adults for two seasons
Bivalent RSV prefusion F protein–based vaccine for preventing cardiovascular hospitalizations in older adults
Clonal hematopoiesis and risk of new-onset myocarditis and pericarditis
Risk of myocarditis or pericarditis with high-dose vs standard-dose influenza vaccine
High-dose vs standard-dose influenza vaccine and cardiovascular outcomes in older adults
Prevalence, determinants, and time trends of cardiovascular health in the WHO African region
New study finds that, after a heart attack, women have worse prognosis when treated with beta-blockers
CNIC-led REBOOT clinical trial challenges 40-year-old standard of care for heart attack patients
Systolic blood pressure and microaxial flow pump–associated survival in infarct-related cardiogenic shock
Beta blockers, the standard treatment after a heart attack, may offer no benefit for heart attack patients and women can have worse outcomes
High Mountain Asia’s shrinking glaciers linked to monsoon changes
All DRII-ed up: How do plants recover after drought?
Research on stigma says to just ‘shake it off’
Scientists track lightning “pollution” in real time using NASA satellite
Millions of women rely on contraceptives, but new Rice study shows they may do more than just prevent pregnancy
Hot days make for icy weather, Philippine study finds
Roxana Mehran, MD, receives the most prestigious award given by the European Society of Cardiology
World's first clinical trial showing lubiprostone aids kidney function
Capturing language change through the genes
Public trust in elections increases with clear facts
Thawing permafrost raised carbon dioxide levels after the last ice age
New DNA test reveals plants’ hidden climate role
Retinitis pigmentosa mouse models reflect pathobiology of human RP59
Cell’s ‘antenna’ could be key to curing diseases
Tiny ocean partnership between algae and bacteria reveals secrets of evolution
Scientists uncover cellular “toolkit” to reprogram immune cells for cancer therapy
Blocking protein control pathway slows rhabdomyosarcoma growth in mice
2026 Hertz Fellowship Application Now Open
[Press-News.org] Pigments that can do moreNew discovery sheds light on the bacterial use of biomass with potential for biofuels and new antibiotics