Optimizing laser irradiation: An in-silico meta-analysis of skin discoloration treatment

Comparing picosecond and nanosecond lasers usage with a newly developed index

2025-07-03

(Press-News.org) In recent years, the application of picosecond laser (PSL) treatment for skin discoloration caused by nevus of Ota has been advancing in the fields of dermatology, plastic surgery, and cosmetic surgery. However, setting appropriate irradiation conditions is necessary to achieve effectiveness. This poses a challenge as previous meta-analyses on laser treatment research did not account for proper laser irradiation levels. Further, such analyses included results from cases with over- and under-irradiation, prompting the need for a more accurate evaluation.

A research team led by Postdoctoral Fellow Yu Shimojo, Specially Appointed Professor Toshiyuki Ozawa, and Professor Daisuke Tsuruta from the Graduate School of Medicine developed the EICF (Excessive Setting Index of Clinical Fluence) indicator using an in-silico mathematical model to determine the appropriate laser irradiation conditions. Based on this index, the irradiation parameters used in clinical practice were evaluated. The team then conducted a meta-analysis on treatment studies that were consistent with theoretical irradiation conditions.

In the case of nevus of Ota, a comparison of PSL and nanosecond laser (NSL) treatments revealed that PSL treatment demonstrated higher efficacy and equivalent safety under proper conditions.

“This achievement provides scientific evidence that answers questions such as ‘Why was it effective?’ and ‘Why did side effects occur?’ in PSL treatment,” said Dr. Shimojo. He concluded, “Although further verification is needed, we hope EICF can be used to ensure safer and more effective laser irradiation conditions.”

The findings were published in JAAD Reviews.

Conflicts of Interest

None declared.

###

About OMU

Established in Osaka as one of the largest public universities in Japan, Osaka Metropolitan University is committed to shaping the future of society through “Convergence of Knowledge” and the promotion of world-class research. For more research news, visit https://www.omu.ac.jp/en/ and follow us on social media: X, Facebook, Instagram, LinkedIn.

END

ELSE PRESS RELEASES FROM THIS DATE:

Climate crisis could force wild vanilla plants and pollinating insects apart, threatening global supply

2025-07-03

Vanilla flavoring is widely used in food, pharmaceutics, and cosmetics. The primary source, Vanilla planifolia, however, is vulnerable to diseases, drought, and heat – stressors expected to become more frequent under climate change. Wild Vanilla species offer a genetic reservoir of crop wild relatives ensuring the future of the vanilla crop. Scientists have now examined how climate change could cause mismatches in habitat overlap of wild vanilla and their pollinating insects. “Climate change may lead to a reduced habitat overlap between Vanilla orchid species and their pollinators, resulting in plant-pollinator decoupling that negatively ...

Teens report spending 21% of each driving trip looking at their phone

2025-07-03

A new study offers a stark reminder of how pervasive cell phone use while driving is for young people, as findings demonstrate teen drivers spend an average of 21.1% of each trip viewing their mobile behind the wheel. In a questionnaire completed by more than 1,100 teen drivers across the US, the young motorists estimated that 26.5% of these glances were for two seconds or longer, a duration which dramatically increases their risk for a crash. Results, published in the peer-reviewed journal Traffic Injury Prevention, show the most common reason for the distraction was entertainment (65%), followed by texting (40%) and navigation (30%). “Distracted ...

Study explores the ‘social norms’ of distracted driving among teens

2025-07-03

A new study from Mass General Brigham researchers offers a stark reminder of how pervasive cell phone use while driving is among young people. The study team developed and disseminated a questionnaire to over 1,100 participants and conducted 20 interviews for high school students to identify the factors influencing them to engage in distracted driving. They found an average of 21% of teen drivers drive distracted and share other insights behind the behavior. Their results are published in Traffic Injury Prevention. ...

Diver-operated microscope brings hidden coral biology into focus

2025-07-03

The intricate, hidden processes that sustain coral life are being revealed through a new microscope developed by scientists at UC San Diego’s Scripps Institution of Oceanography. The diver-operated microscope — called the Benthic Underwater Microscope imaging PAM, or BUMP — incorporates pulse amplitude modulated (PAM) light techniques to offer an unprecedented look at coral photosynthesis on micro-scales. In a new study, researchers describe how the BUMP imaging system makes it possible to study the health and physiology of coral reefs in their natural habitat, ...

Enhancing the “feel-good” factor of urban vegetation using AI and street view images

2025-07-03

Osaka, Japan – The benefits of urban green spaces in cities, in terms of ecological sustainability, climate modification, and human well-being, have been known for decades. More recently, additional economic and restorative payoffs from diverse and colorful plantings have been recognized. Now, a research team from Japan has developed a new method to identify vegetation color, structure, and seasonal changes in urban settings. In a study published in Landscape Ecology, researchers at The University of Osaka reveal an innovative approach to capture seasonal changes in urban plant species. This method combines artificial intelligence ...

A single genetic mutation may have made humans more vulnerable to cancer than chimpanzees

2025-07-03

SACRAMENTO, Calif. — New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates. This insight could lead to more powerful cancer treatments. The study was published in Nature Communications. It revealed a tiny genetic difference in an immune protein called Fas Ligand (FasL) between humans and non-human primates. This genetic mutation makes the FasL protein vulnerable to being disabled by plasmin, a tumor-associated ...

Innovative nanocomposite hydrogel shows promise for cartilage regeneration in osteoarthritis treatment

2025-07-03

A research team from Northwest University, China, has developed a breakthrough nano-composite hydrogel system to address the dual challenges of inflammation and cartilage damage in osteoarthritis (OA), a leading cause of joint disability worldwide. Published in Engineering, the study confirms that the dual-drug-loaded hydrogel promotes cartilage repair through synergistic immune regulation and chondrocyte differentiation, offering a novel therapeutic strategy for OA. OA is characterized by persistent inflammation and impaired cartilage regeneration, with existing treatments failing ...

2025 Guangci Laboratory Medicine Innovation and Development Conference

2025-07-03

The 2025 Guangci Laboratory Medicine Innovation and Development Conference was successfully concluded at Shanghai Qingsongcheng Hotel during June 5-8, 2025! With the theme of "Innovation, Guidance, and Development", this conference successfully brought together nearly 100 well-known experts and scholars at home and abroad, and carried out in-depth dialogues and collisions of ideas around the cutting-edge hotspots in the field of clinical and laboratory medicine. Through diversified academic exchanges, the conference has built a high-level technology sharing and achievement display platform for laboratory medicine ...

LabMed Discovery is included in the ICI World Journals database

2025-07-03

In May 2025, under the review of the Polish ICI World of Journals (Copernicus Index Database), LabMed Discovery magazine was officially included in the ICI World of Journals database. This marks an important step for LabMed Discovery on the international academic stage, and is also a high recognition of the journal's long-term efforts in improving academic quality and promoting academic exchanges. ICI World of Journals is the world's third largest scientific journal database, which includes and evaluates 45,000 journals from more than 150 countries and regions. The database adopts strict review standards and conducts multi-dimensional ...

LabMed Discovery is included in the China Open Access Journal (COAJ) database

2025-07-03

After rigorous evaluation and review, LabMed Discovery was officially included in China Open Access Journal Database (COAJ) in May 2025. This progress marks that LabMed Discovery has been officially recognized in terms of academic quality, publishing standards and open access. It is also another achievement of LabMed Discovery following being selected into the ICI international database this month. This proves the improvement of LabMed Discovery's academic communication and influence, and is of great significance in furthering the speed, breadth and visibility of the journal's international dissemination. We ...

Bright children from poorer backgrounds twice as likely to receive hospital mental health treatment than affluent high-achievers

Internationally recognized malaria researcher Stefan Kappe, Ph.D., appointed new director of the UM School of Medicine's Center for Vaccine Development and Global Health

For video-on-demand platforms, release strategy matters: streaming episodes gradually boosts consumers’ searches, subscription rates

Tarlatamab with anti-PD-L1 as first-line maintenance after chemo-immunotherapy for ES-SCLC demonstrates acceptable safety profile and unprecedented overall survival

Optimizing laser irradiation: An in-silico meta-analysis of skin discoloration treatment

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: