(Press-News.org) EMBL-EBI scientists and collaborators at Heidelberg University have developed CORNETO, a new computational tool that uses machine learning to gain meaningful insights from complex biological data. CORNETO enables users to extract molecular networks – maps of how genes, proteins, and signalling pathways interact – by combining experimental data from different samples and conditions with prior biological knowledge, such as signalling or metabolic networks. This can help us to better understand the mechanisms that lead a cell to be healthy or diseased.
Understanding how molecules interact inside our cells is key to uncovering the mechanisms that can go wrong, leading to disease. But as the types of omics data available to researchers grow in size and complexity, researchers often struggle to extract useful, meaningful patterns from them. CORNETO, which stands for Constrained Optimisation for the Recovery of NETworks from Omics, combines machine learning techniques with biological prior knowledge to simultaneously analyse multiple types of omics data, including transcriptomics, proteomics, and metabolomics.
“We wanted to solve a common challenge in systems biology: how to make sense of omics data when you have so much complex data available all at once,” said Julio Saez-Rodriguez, Head of Research at EMBL-EBI and Professor on leave at Heidelberg University. “CORNETO helps by combining these complex data with prior information coming from biological databases to find patterns that are consistent, interpretable, and biologically meaningful.”
Unified omics analyses
Traditionally, scientists analyse data from one condition at a time – for example, comparing healthy cells to diseased ones – and build separate interaction networks for each. But this approach can miss the bigger picture. CORNETO uses machine learning to analyse multiple samples or conditions together, highlighting biological processes that are shared across datasets, and pinpointing the differences between samples. CORNETO is also designed to allow researchers to customise it for specific use cases or extend it to new data types as needed.
“Using CORNETO is like finding the common threads in a tangled web,” explained Pablo Rodríguez-Mier, postdoctoral researcher at Heidelberg University. “It helps researchers pull out the key biological processes that are happening across many samples and understand what’s different or the same in each one.”
Real-world applications
Using CORNETO is especially valuable to researchers working in fields like cancer research, where there are similarities across patients, but no two patients are exactly alike. To demonstrate this, the researchers used CORNETO to analyse gene expression data from multiple cancer patients to discover which specific intracellular signalling pathways were behaving abnormally.
Using only transcriptomics data, CORNETO identified key deregulated kinases, enzymes that regulate cell signalling, which were also detected independently using phosphoproteomics. The resulting networks revealed both shared pathways and patient-specific differences, a step toward the kinds of insights that could one day support personalised treatment strategies.
CORNETO is also currently being used in the EU research project DECIDER to identify deregulated signalling pathways associated with chemotherapy resistance in ovarian cancer patients.
The researchers also used CORNETO to analyse metabolic pathways in yeast strains in which different genes were inactivated. Here, CORNETO was able to find the key processes the yeast cells were using to survive and grow. Understanding these essential processes could help scientists design better yeast strains for making biofuels and other products for industrial manufacturing.
Open-source and ready to use
CORNETO is available as open-source software on GitHub. Here, you can also find tutorials, example datasets, and modular code to adapt CORNETO to your needs.
END
CORNETO: Machine learning to decode complex omics data
New tool combines biological knowledge with machine learning to help researchers extract meaningful insights from complex omics data
2025-07-22
ELSE PRESS RELEASES FROM THIS DATE:
Mount Sinai researcher decodes brain and body communication that drives aging and depression
2025-07-22
NEW YORK, New York, USA, 22 July 2025 – In a comprehensive Genomic Press interview published in Brain Medicine today, Dr. Hamilton Se-Hwee Oh reveals groundbreaking insights into the complex dialogue between our brains and bodies that fundamentally shapes aging, depression, and neurodegenerative disease. Working at Mount Sinai's prestigious Brain-Body Institute and Ronald M. Loeb Center for Alzheimer's Disease in New York City, Dr. Oh bridges multiple scientific disciplines to decode ...
Some people could sound angrier when complaining, new study finds
2025-07-22
It has long been established that emotions reflect in our voice – this helps us communicate more purposefully and gives listeners cues as to how they should interpret what we say. But what emotions predominate in complaints – and how do they differ between groups? Researchers in Switzerland and Canada investigated and published their findings in Frontiers in Communication.
“Complaining is differentiated from neutral speech by changes in vocal expression. Complainers tend to change their intonation, pitch, rhythm, and emphasis, making them sound more emotive and expressive,” ...
Respiratory related ER visits decreased 20 percent after coal-processing plant closure
2025-07-22
NEW YORK, NY – July 21, 2025 – A new study by NYU Langone Health researchers found that the shutdown of a significant fossil fuel pollution source near Pittsburgh, PA, resulted in immediate improvements in respiratory health. The study is available online starting July 22 in the American Journal of Respiratory and Critical Care Medicine, a journal of the American Thoracic Society.
Assessing data from nearby local and federal air quality monitors, the researchers tracked the air pollution health effects on residents near the Shenango plant before and after its closure in 2016.
Results showed that within the first few ...
Earthquake caught on camera
2025-07-22
Kyoto, Japan -- During the midday Friday prayer hours on 28 March 2025, a magnitude 7.7 earthquake struck central Myanmar along the Sagaing Fault. With an epicenter close to Mandalay, the country's second-largest city, it was the most powerful earthquake to strike Myanmar in more than a century and the second deadliest in its modern history.
The cause was a strike-slip fault, in which two masses of earth "slip" past each other horizontally along a vertical fault plane. To an observer, it would look like the ground were split in two along a defined line, with both sides being wrenched past each other ...
How a decaploid plant evolved to fight disease with powerful compounds
2025-07-22
Researchers have decoded the chromosome-level genome of Houttuynia cordata, an important East Asian medicinal plant known for its strong flavor and wide pharmacological use. This species was found to be decaploid, containing ten sets of chromosomes, and has undergone multiple genome duplications during evolution. The team identified significantly expanded gene families involved in the biosynthesis of medicinal alkaloids, including STR, DDC, 6OMT, and 4OMT. High expression of these genes in root and rhizome tissues supports their vital role in alkaloid accumulation. This study not only unveils ...
Where did RNA come from?
2025-07-22
LA JOLLA, CA—In living organisms today, complex molecules like RNA and DNA are constructed with the help of enzymes. So how did these molecules form before life (and enzymes) existed? Why did some molecules end up as the building blocks of life and not others? A new study by Scripps Research scientists helps answer these longstanding questions.
The results, published in the chemistry journal Angewandte Chemie on June 27, 2025, show how ribose may have become the sugar of choice for RNA development. They found that ribose binds to phosphate—another molecular ...
Health: Anti-obesity medications associated with weight rebound post-treatment
2025-07-22
Patients prescribed drugs to help them lose weight may experience a rebound in weight gain after halting their prescription, finds a meta-analysis published in BMC Medicine. The study, which analyses data for patients receiving weight loss drugs across 11 randomised trials, suggests that while the amount of weight regain varies depending on the specific drug, there is a broad trend in associated weight regain after the course of medication concluded.
Six anti-obesity medications (AOMs) have been approved by the US FDA for use in assisting with weight loss, including orlistat, ...
“Forever chemicals” linked to higher risk of type 2 diabetes
2025-07-21
New York, NY (July 21, 2025) — Exposure to a class of synthetic chemicals known as per- and polyfluoroalkyl substances (PFAS)—often called “forever chemicals”—may increase the risk of developing type 2 diabetes, according to a new study led by Mount Sinai researchers. The findings were published today in eBioMedicine.
The team conducted a nested case-control study (an observational study that is conducted within a larger cohort study) within BioMe, a large, electronic health record-linked research database comprising ...
Near tripling in US reported lidocaine local anesthetic poisonings/deaths over past decade
2025-07-21
Poisonings and deaths linked to the use of the local anaesthetic lidocaine have nearly tripled in the US over the past decade, finds an analysis of National Poison Data System (NPDS) reports, published online in the journal Regional Anesthesia & Pain Medicine
This increase contrasts with the overall fall in reported poisonings and deaths from other types of local anaesthetics over the same period, the analysis shows.
Local anaesthetics are widely used for pain control, but carry an inherent risk of systemic toxicity, referred to as LAST, prompting multiple professional societies to issue ...
Despite self-perceived sensitivities, study finds gluten and wheat safe for many people with IBS
2025-07-21
A new study from McMaster University researchers has found that many people with irritable bowel syndrome (IBS) who believe they are sensitive to gluten or wheat may not actually react to these ingredients.
IBS is an intestinal disorder that affects an estimated 10 per cent of Canadians – one of the highest prevalence rates globally, according to the Canadian Digestive Health Foundation. It can be disruptive and debilitating, and its underlying cause is unclear.
The study, published in The Lancet Gastroenetrology ...
LAST 30 PRESS RELEASES:
Lizard genetics provide new perspective on evolution
Can a Stevia-derived sweetener improve hair loss treatment?
Method to assess the status of wild reindeer may help with conservation efforts
Do imported cut flowers spread livestock viruses?
Does prior incarceration contribute to poor health later in life?
Could slime mold microbes be a source of potent antimicrobials?
Record-breaking 2024 Amazon fires drive unprecedented carbon emissions and ecosystem degradation
Birds thrive despite pollution from ‘forever’ chemicals
Deadwood brings wild orchids to life
Changes in gut microbiota influence which patients get AIG-related neuroendocrine tumors
Medicaid expansion linked to improved long-term survival in cancer patients
Women with surgical menopause may exit workforce earlier, but hormone therapy could help
Trailblazing Young Scientists honored with $250,000 prizes at Blavatnik National Awards Gala
Revolutionary blood test for ME / Chronic Fatigue unveiled
Calorie labelling linked to 2% average reduction in energy content of menu items
Widely prescribed opioid painkiller tramadol not that effective for easing chronic pain
Exercise snacks may boost cardiorespiratory fitness of physically inactive adults
15,000 women a year with breast cancer could benefit from whole genome sequencing, say researchers
Study highlights risks of Caesarean births to future pregnancies
GLP-1 agonists pose emerging challenge for PET-CT imaging, study finds
Scripps Research scientists unlock new patterns of protein behavior in cell membranes
Panama Canal may face frequent extreme water lows in coming decades
Flash Joule heating lights up lithium extraction from ores
COMBINEDBrain and MUSC announce partnership to establish biorepository for pediatric cerebrospinal fluid and CNS tissue bank
Questionable lead reporting for drinking water virtually vanished after Flint water crisis, study reveals
Assessing overconfidence among national security officials
Bridging two frontiers: Mitochondria & microbiota, Targeting Extracellular Vesicles 2025 to explore game-changing pathways in medicine
New imaging tech promises to help doctors better diagnose and treat skin cancers
Once dominant, US agricultural exports falter amid trade disputes and rising competition
Biochar from invasive weed shields rice from toxic nanoplastics and heavy metals
[Press-News.org] CORNETO: Machine learning to decode complex omics dataNew tool combines biological knowledge with machine learning to help researchers extract meaningful insights from complex omics data