Global estimates of lives and life-years saved by COVID-19 vaccination during 2020-2024

JAMA Health Forum

2025-07-25

(Press-News.org) About The Study: This comparative effectiveness study found that COVID-19 vaccinations averted 2.5 million deaths
during 2020-2024 (sensitivity range estimates, 1.4-4.0 million). Estimates in this study are substantially more conservative than previous calculations focusing mostly on the first year of vaccination, but they still clearly demonstrate a major overall benefit from COVID-19 vaccination during the years 2020-2024. Most benefits in lives and life-years saved was secured for a portion of older persons, a minority of the global population.

Corresponding Author: To contact the corresponding author, John P. A. Ioannidis, M.D., D.Sc., email jioannid@stanford.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamahealthforum.2025.2223)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

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