(Press-News.org) PROVIDENCE, R.I. [Brown University] — Using a custom-built tool to analyze electrical activity from neurons, researchers at Brown University have identified a brain-based biomarker that could be used to predict whether mild cognitive impairment will develop into Alzheimer’s disease.
“We’ve detected a pattern in electrical signals of brain activity that predicts which patients are most likely to develop the disease within two and a half years,” said Stephanie Jones, a professor of neuroscience affiliated with Brown’s Carney Institute for Brain Science who co-led the research. “Being able to noninvasively observe a new early marker of Alzheimer’s disease progression in the brain for the first time is a very exciting step.”
The findings were published in Imaging Neuroscience.
Working with collaborators at the Complutense University of Madrid in Spain, the research team analyzed recordings of brain activity from 85 patients diagnosed with mild cognitive impairment and monitored disease progress over the next several years. The recordings were made using magnetoencephalography, or MEG — a noninvasive technique to record electrical activity in the brain — while patients were in a resting state with their eyes closed.
Most methods for studying MEG recordings compress and average the detected activity, making it difficult to interpret at the neuronal level. Jones and other researchers at Brown pioneered a computational tool, called the Spectral Events Toolbox, that reveals neuronal activity as discrete events, showing exactly when and how often activity occurs, how long it lasts and how strong or weak it is. The tool has become widely used and has been cited in more than 300 academic studies.
Using the Spectral Events Toolbox, the team looked at brain activity events in patients with mild cognitive impairment, occurring in the beta frequency band –– a frequency that has been implicated in memory processing, making it important to study in Alzheimer’s disease, according to Jones. They discovered distinct differences in the beta events of the participants who developed Alzheimer’s disease within two and a half years, in comparison with those who did not.
“Two and a half years prior to their Alzheimer’s disease diagnosis, patients were producing beta events at a lower rate, shorter in duration and at a weaker power,” said Danylyna Shpakivska, the Madrid-based first author of the study. “To our knowledge, this is the first time scientists have looked at beta events in relation to Alzheimer’s disease.”
Spinal fluid and blood biomarkers can identify the presence of toxic beta amyloid plaques and tau tangles –– proteins that build up in the brain and are thought to contribute to Alzheimer’s disease symptoms. A biomarker from brain activity itself represents a more direct method of assessing how neurons respond to this toxicity, said David Zhou, a postdoctoral researcher in Jones’ lab at Brown who will lead the next phase of the project.
Jones envisions that the Spectral Events Toolbox could be used by clinicians to diagnose Alzheimer’s disease before it progresses.
“The signal we’ve discovered can aid early detection,” Jones said. “Once our finding is replicated, clinicians could use our toolkit for early diagnosis and also to check whether their interventions are working.”
Meanwhile, Jones and her team will move into a new phase of research, funded by a Zimmerman Innovation Award in Brain Science from the Carney Institute.
“Now that we’ve uncovered beta event features that predict Alzheimer’s disease progression, our next step is to study the mechanisms of generation using computational neural modeling tools,” Jones said. “If we can recreate what’s going wrong in the brain to generate that signal, then we can work with our collaborators to test therapeutics that might be able to correct the problem.”
The research was supported by the National Institutes of Health, including the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, in addition to funding from agencies in Spain.
END
Brown University neuroscientists help identify a biomarker for Alzheimer’s disease progression
Researchers at the Carney Institute for Brain Science have identified electrical activity in the brain that could predict progression to Alzheimer’s disease.
2025-08-04
ELSE PRESS RELEASES FROM THIS DATE:
Imperfect underground processes help filter wastewater in Florida Keys
2025-08-04
UNIVERSITY PARK, Pa. — For seaside communities reducing their pollution, nitrogen is a prime target. Often found in agricultural runoff and human waste, nitrogen and the nitrogen-containing nitrate molecule can enter coastal waters as a critical nutrient for algae. Its abundance leads to a surplus of algal blooms, upsetting delicate balances of plant and marine life.
Many South Florida communities dispose of treated wastewater — which contains nitrate and more — by shallowly injecting it ...
Both flexibility and persistence make some birds successful in human-made environments
2025-08-04
(Santa Barbara, Calif.) — Across North America, grackles are virtuosos of adaptation. The small- to medium-sized New World blackbirds are particularly social and known for foraging skills that help them flourish in environments ranging from rural farms to urban parking lots.
They are often viewed as rather bold and somewhat amusing birds that pick up French fries and other fast food scraps — or, alternatively, as annoying pests that eat our grain crops.
UC Santa Barbara scientist Corina Logan, however, is fascinated by what goes on in their bird brains and how they manage to adapt to the growing footprint of human-made environments. In a pair of papers ...
Biodiversity matters in every forest, but even more in wetter ones
2025-08-04
Biodiversity is important in every ecosystem. Research has shown having a richer diversity of plant and animal species bolsters ecosystem functioning and stability, making habitats more resilient to the threats of things like pests, disease and climate change.
Still, there are varying degrees of importance. Now, research led by the University of Michigan reveals some of the real-world implications of this fact in forests, providing valuable insights for land managers and conservationists working to protect these ...
Phase 3 study supports use of canagliflozin for type 2 diabetes in children and adolescents
2025-08-04
Embargoed for release until 5:00 p.m. ET on Monday 4 August 2025
Follow @Annalsofim on X, Facebook, Instagram, Bluesky, and Linkedin
Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives ...
Small protein, big impact: Insights into how bacteria stabilize a key outer membrane complex
2025-08-04
Ikoma, Japan—Gram-negative bacteria pose a significant threat to global health due to their high resistance to antibiotics compared to that of Gram-positive bacteria. Their formidable defensive capabilities stem from their outer membrane (OM), which acts as a selective barrier against harmful compounds. The OM is not merely a static shield but a dynamic structure crucial for the bacteria’s survival and virulence. Thus, understanding how the OM is built and maintained is critical in our battle against drug-resistant infections.
To construct such an ...
Study finds gaps in evidence for air cleaning technologies designed to prevent respiratory infections
2025-08-04
A new study led by researchers from the University of Colorado Anschutz Medical Campus and the National Institute for Occupational Safety and Health (NIOSH) through the Centers for Disease Control and Prevention (CDC) finds that although many technologies claim to clean indoor air and prevent the spread of viruses like COVID-19 and the flu, most have not been tested on people and their potential risks are not yet fully understood.
Published today in the Annals of Internal Medicine, the research analyzed nearly 700 studies between 1929 and 2024 on engineering controls such as HEPA filters, ...
Study shows major health insurance gap for some adopted children
2025-08-04
COLLEGE PARK, M.d. – People in America adopt hundreds of thousands of children every year, but not all of them receive health insurance once adopted into their second home. A study by University of Maryland (UMD) School of Public Health, out today in Health Affairs, reveals major differences in coverage depending on adoption type (domestic or international) and citizenship status of the adoptive parent.
“Adopted children generally have more and different health needs – such as cognitive or physical difficulties – than non-adopted children. Previous studies, ...
Midwestern butterfly count: Big data yields bad news and clues
2025-08-04
While analyzing the mountains of data harvested from three decades of butterfly counting in the Midwest, a Michigan State University PhD candidate had seen enough studies to be braced for bad news.
But, as reported in this week’s Proceedings of the National Academy of Sciences, finding that none of the 136 species of butterflies’ populations increased over that time took Wendy Leuenberger aback.
“We expected to find that at least some species had done well over the past 32 years,” she said.
Leuenberger ...
New mega RNA virus may hold the key to mass oyster die-offs
2025-08-04
EMBARGOED UNTIL 4-AUG-2025 15:00 ET
Scientists have discovered a previously unknown virus in farmed Pacific oysters during a mass die-off in B.C., Canada.
The discovery serves as a reminder that growers should exercise caution when moving young oysters internationally and domestically, to prevent potential spread of pathogens, according to a paper published today in the Proceedings of the National Academy of Sciences.
“We’ve recently seen annual mass die-offs in B.C. and elsewhere of Pacific oysters, the most widely farmed shellfish worldwide,” said first author Dr. Kevin Zhong, research associate in the UBC department ...
Organized scientific fraud is growing at an alarming rate
2025-08-04
From fabricated research to paid authorships and citations, organized scientific fraud is on the rise, according to a new Northwestern University study.
By combining large-scale data analysis of scientific literature with case studies, the researchers led a deep investigation into scientific fraud. Although concerns around scientific misconduct typically focus on lone individuals, the Northwestern study instead uncovered sophisticated global networks of individuals and entities, which systematically work together to undermine the integrity of academic publishing.
The problem is so widespread that the publication of fraudulent science is ...
LAST 30 PRESS RELEASES:
Trailblazing Young Scientists honored with $250,000 prizes at Blavatnik National Awards Gala
Revolutionary blood test for ME / Chronic Fatigue unveiled
Calorie labelling linked to 2% average reduction in energy content of menu items
Widely prescribed opioid painkiller tramadol not that effective for easing chronic pain
Exercise snacks may boost cardiorespiratory fitness of physically inactive adults
15,000 women a year with breast cancer could benefit from whole genome sequencing, say researchers
Study highlights risks of Caesarean births to future pregnancies
GLP-1 agonists pose emerging challenge for PET-CT imaging, study finds
Scripps Research scientists unlock new patterns of protein behavior in cell membranes
Panama Canal may face frequent extreme water lows in coming decades
Flash Joule heating lights up lithium extraction from ores
COMBINEDBrain and MUSC announce partnership to establish biorepository for pediatric cerebrospinal fluid and CNS tissue bank
Questionable lead reporting for drinking water virtually vanished after Flint water crisis, study reveals
Assessing overconfidence among national security officials
Bridging two frontiers: Mitochondria & microbiota, Targeting Extracellular Vesicles 2025 to explore game-changing pathways in medicine
New imaging tech promises to help doctors better diagnose and treat skin cancers
Once dominant, US agricultural exports falter amid trade disputes and rising competition
Biochar from invasive weed shields rice from toxic nanoplastics and heavy metals
Rice University announces second cohort of Chevron Energy Graduate Fellows
Soil bacteria and minerals form a natural “battery” that breaks down antibiotics in the dark
Jamestown colonists brought donkeys, not just horses, to North America, old bones reveal
FIU cybersecurity researchers develop midflight defense against drone hijacking
Kennesaw State researcher aims to discover how ideas spread in the digital age
Next-generation perovskite solar cells are closer to commercial use
Sleep patterns linked to variation in health, cognition, lifestyle, and brain organization
University of Oklahoma researcher awarded funding to bridge gap between molecular data and tissue architecture
Nationally-recognized pathologist Paul N. Staats, MD, named Chair of Pathology at University of Maryland School of Medicine
The world’s snow leopards are very similar genetically. That doesn’t bode well for their future
Researchers find key to stopping deadly infection
Leafcutter ants have blind spots, just like truck drivers
[Press-News.org] Brown University neuroscientists help identify a biomarker for Alzheimer’s disease progressionResearchers at the Carney Institute for Brain Science have identified electrical activity in the brain that could predict progression to Alzheimer’s disease.