BD² announces new funding opportunities focused on biology of bipolar disorder
BD² opens its fourth round of Discovery Research funding for bipolar disorder with $18 million available.
2025-09-10
(Press-News.org) Washington, D.C.: Today, Breakthrough Discoveries for thriving with Bipolar Disorder (BD²) announced the opening of a fourth round of funding opportunities for the Discovery Research program. BD² invites scientists across all disciplines to apply for up to $4.5 million per grant. Successful teams will undertake groundbreaking research into the genetic, molecular, cellular, circuit, and behavioral mechanisms of bipolar disorder, especially applications that address the following:
Cellular and molecular mechanisms of mood-state switching;
Biological mechanisms by which manic or depressive episodes are induced by external risk factors, such as pregnancy, childbirth, substance use, or seasonal changes; or
Using experimental pharmacology to test causality of a molecular or circuit-level mechanism underlying mood-state switching.
“Discovery-focused research is the cornerstone of innovation. By prioritizing hypothesis-driven, collaboration-forward science, this program is expanding the idea space for new treatments, diagnostic tools, and a deeper foundational understanding of bipolar disorder. Scaled science of this kind is redefining what’s possible in the field.” said Cara Altimus, PhD, Managing Director of BD².
“The fourth round of funding for the Discovery Research program is a significant milestone toward continuing to make real and impactful discoveries that can drive new therapies and interventions in bipolar disorder.” said Eric J. Nestler, MD, PhD, Icahn School of Medicine at Mount Sinai, and Chair, BD² Research Programs. “This program continues to connect researchers, drive innovative thinking, and champion real-time data sharing and open access practices that can close fundamental gaps in our understanding of bipolar disorder.”
To date, BD² has committed $89 million to research that accelerates scientific discovery and advances in clinical care. Through its emphasis on collaboration, data sharing, and interdisciplinary approaches, BD2 is reshaping the landscape of bipolar disorder research.
For more information on the Discovery Research program and how to apply, visit https://www.bipolardiscoveries.org/funding/rfa-opportunities/
###
About BD²: Breakthrough Discoveries for thriving with Bipolar Disorder is the first organization focused on funding and advancing research and care for bipolar disorder on a global scale. Our collaborative, open-science approach is designed to transform and shorten the time it takes for scientific breakthroughs to make a meaningful difference in the lives of the tens of millions of people with bipolar disorder. The BD² Discovery Grants, Brain Omics, Genetics Platforms, and the Integrated Network are designed to share data, methods, and resources across initiatives and the bipolar disorder research community. For more information, please visit bipolardiscoveries.org.
END
ELSE PRESS RELEASES FROM THIS DATE:
2025-09-10
Household waste constitutes 30–40% of municipal solid waste globally. Separating waste at the household level into compostable, recyclable, and non-recyclable is a crucial first step for local governments to process solid waste effectively. However, large gaps between a person’s willingness to separate waste and actually separating waste have been seen across the world. Understanding the factors that affect people’s intention and behavior of separating household waste can help create more effective policies regarding household-level waste separation.
However, ...
2025-09-10
Flexible pressure sensors can detect subtle mechanical stimuli, making them suitable for use in wearable sensors for human health monitoring and motion analysis. However, current sensors suffer from insufficient sensitivity, poor durability, and subpar stability. In a new study, taking inspiration from cat whiskers, researchers developed novel biomass fiber/sodium alginate aerogel (BFA)-based sensors that demonstrated excellent pressure sensitivity, durability, and rapid response, while being suitable for human physiological monitoring and motion analysis.
The rapid development of wearable electronic sensors for use in health monitoring, ...
2025-09-10
Osaka, Japan – There are many potential causes of infertility, and it can be challenging to pin down just what the problem is when a couple is having trouble getting pregnant. Now, researchers show that a few key proteins have a major effect on sperm development, and therefore male fertility.
In a study published this month in Nature Communications, researchers from The University of Osaka have revealed that proteins forming a specialized structure are required for correct sperm function.
Sperm are propelled by flagella, which are like long ...
2025-09-10
A new poll of 2,143 California adults conducted by University of California, Irvine researchers reveals overwhelming bipartisan support for stricter regulations on children's use of digital technology, including school smartphone restrictions and social media age limits.
“There are very few issues with this level of bipartisan support in today’s polarized policy environment, but the message from parents and other adults in our poll was clear and crossed party lines. Adults are worried about the impacts of smartphones and social media on children’s learning and mental health,” said the survey’s authors, Kelli ...
2025-09-10
A new study from the University of North Carolina at Chapel Hill has uncovered that shark meat sold in U.S. grocery stores, seafood markets, and online vendors often comes from endangered species and is frequently mislabeled. Researchers purchased and DNA barcoded 29 shark meat products to determine their species identity, finding that 93% of samples were ambiguously labeled and included meat from 11 different shark species.
Among the species identified were the great hammerhead and scalloped hammerhead, both listed as critically endangered by the International Union for Conservation of Nature (IUCN). Despite global ...
2025-09-10
Sharks have been around for more than 450 million years, but these days they are in deep trouble. Since the 1970s, shark populations have gone down by more than 70% due to unsustainable practices such as shark finning, bycatch, and overfishing, habitat destruction, pollution, and climate change. The International Union for the Conservation of Nature (IUCN) has estimated that of the approximately 550 species of sharks in existence, 14% are vulnerable, 11% endangered, and 12% critically endangered. As a result, 74 species of shark are considered at risk by the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), meaning that ...
2025-09-10
Peer-reviewed, literature review
Scientists warn that powerful industries are quietly shaping laws, research and public messaging in ways that delay environmental and health action
Study brings together real-world examples - from fossil fuel-funded museums to biased science conferences - to expose how ‘capture strategies’ work
The study calls for stronger conflict of interest rules and greater transparency in funding
For over 80 years, researchers have documented how powerful industries can exert influence over the very institutions meant to regulate them - a phenomenon known as ‘corporate capture’.
From oil ...
2025-09-10
CLEVELAND, Ohio (September 10, 2025)—Despite evidence suggesting the safety of hormone therapy for patients with a history of low-grade endometrial or epithelial ovarian cancer, a new survey shows that many gynecologists and some gynecologic oncologists are still uncomfortable prescribing the therapy for this patient population. This indicates a need for more clinician education to help overcome lingering misconceptions. Results of the survey are published online today in Menopause, the journal of The Menopause Society.
Although ...
2025-09-10
Planetary scientists believe they can now predict the green glow of an aurora in the night sky above Mars, and they have the images to prove it.
The first observations of a visible-light aurora from the surface of the Red Planet were made by NASA’s Perseverance Mars rover in 2024. Now, presenting at the Europlanet Science Congress–Division of Planetary Science (EPSC–DPS) joint meeting in Helsinki this week, Dr Elise Wright Knutsen of the University of Oslo will reveal a second snapshot of the aurora by Perseverance and, more importantly, the tools to predict when an aurora will occur on Mars.
"The fact that we captured the aurora again demonstrates that our method ...
2025-09-10
Researchers including those at the University of Tokyo have made a surprising discovery hiding in people’s mouths: Inocles, giant DNA elements that had previously escaped detection. These appear to play a central role in helping bacteria adapt to the constantly changing environment of the mouth. The findings provide fresh insight into how oral bacteria colonize and persist in humans, with potential implications for health, disease and microbiome research.
You might think that modern medical science knows everything there is to know about ...
LAST 30 PRESS RELEASES:
[Press-News.org] BD² announces new funding opportunities focused on biology of bipolar disorder
BD² opens its fourth round of Discovery Research funding for bipolar disorder with $18 million available.
