Efficacy and safety of GLP-1 RAs in children and adolescents with obesity or type 2 diabetes

JAMA Pediatrics

2025-09-15

(Press-News.org) About The Study: In this systematic review and meta-analysis of 18 trials, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly improved glycemic, weight, and cardiometabolic outcomes in children and adolescents with type 2 diabetes or obesity. Available data over a relatively short follow-up suggested suicidal ideation or behaviors were not significantly different, although gastrointestinal adverse effects warrant attention in long-term management.

Corresponding Author: To contact the corresponding author, Jingchuan Guo, MD, PhD, email guoj1@ufl.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamapediatrics.2025.3243)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Efficacy and safety of GLP-1 RAs in children and adolescents with obesity or type 2 diabetes

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