The rise in early-onset cancer in the US population— more apparent than real

JAMA Internal Medicine

2025-09-29

(Press-News.org) About The Study: The rise in early-onset cancer incidence does not consistently signal a rise in the occurrence of clinically meaningful cancer. While some of the increase in early-onset cancer is likely clinically meaningful, it appears small and limited to a few cancer sites. Much of the increase appears to reflect increased diagnostic scrutiny and over-diagnosis. Interpreting rising incidence as an epidemic of disease may lead to unnecessary screening and treatment while also diverting attention from other more pressing health threats in young adults.

Corresponding Author: To contact the corresponding author, H. Gilbert Welch, MD, MPH, email drgilwelch@gmail.com.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamainternmed.2025.4917)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2025.4917?guestAccessKey=fff8b54b-04ee-4400-b341-d8b61531cc46&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=092925

END

ELSE PRESS RELEASES FROM THIS DATE:

Scientists reveal functional RNA splitting mechanism behind origin of Type V CRISPR systems

2025-09-29

CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR RNA-guided cleavage. Type V CRISPR-Cas (Cas12) systems, in particular, serve as one of today’s most powerful tools for genome editing, especially in basic research, medicine, and agriculture. Researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences (CAS), together with Assoc. Prof. LIU Junjie from Tsinghua University ...

Study shows HPV vaccine protects vaccinated — and unvaccinated — women

2025-09-29

September 29, 2025 (BRONX, NY)—A large, long-term study led by an Albert Einstein College of Medicine researcher has found that the introduction of the human papillomavirus (HPV) vaccine in community settings is highly effective in protecting young women from infections caused by the cervical-cancer-causing virus—including women who didn’t even receive the vaccine. The study was published today in JAMA Pediatrics. “There are two encouraging takeaways from our study,” said lead ...

Childhood overeating can be a harbinger of later mental health struggles in girls, study finds

2025-09-29

Girls who overeat regularly in the preschool years are more likely to experience anxiety, impulsivity and hyperactivity in adolescence, according to a new study led by researchers at McGill University and the Douglas Research Centre. The study followed more than 2,000 Quebec children using provincial data, tracking eating patterns reported by caregivers in early childhood and assessing mental-health symptoms when participants turned 15. The link between overeating and later difficulties was seen in girls, but not in boys. Takeaway for caregivers The findings ...

Over 99% have a risk factor before heart attack, stroke or heart failure

2025-09-29

One or more risk factors above optimal levels — high blood pressure, cholesterol, glucose or smoking — almost always precedes a cardiac event Findings refute the commonly held belief that heart disease often strikes people without warning Authors urge greater attention to early detection and control of these modifiable risks CHICAGO --- More than 99% of people who went on to suffer a heart attack, stroke or heart failure already had at least one risk factor above optimal level beforehand, ...

American College of Cardiology issues scientific statement on inflammation and cardiovascular disease

2025-09-29

WASHINGTON (September 29, 2025) — The American College of Cardiology (ACC) released today its second Scientific Statement, Inflammation and Cardiovascular Disease (CVD). The statement emphasizes years of clinical and basic science research, confirming that inflammation is an important underlying contributor to several CVDs, including coronary artery disease and heart failure. Key Points: High-sensitivity C-reactive protein (hsCRP) is an inexpensive and widely available blood test. While there has been debate within the medical community regarding the utility of hsCRP, this statement details the data confirming its ...

Multi-omics machine learning can detect ALS 10 years before symptom appears

2025-09-29

A new study applying multi-omics techniques and machine learning identified 33 plasma proteins that differ significantly in patients with amyotrophic lateral sclerosis (ALS). The findings suggest ALS could be detected up to 10 years before symptoms appear, offering promise for reliable diagnostic biomarkers. The integration of advanced high-throughput sequencing technologies, such as whole genome sequencing (WGS) for the early detection of rare diseases, such as ALS, could give clinicians and patients a critical window for ...

Two-drug combination shows promise in helping heal chronic wounds

2025-09-29

University of Oregon researchers have tested a new combination drug therapy that could dismantle the difficult-to-treat bacteria inhabiting chronic wound infections. Their findings, published Sept. 29 in the journal Applied and Environmental Microbiology, illuminate ways to develop more effective antimicrobial treatments that promote healing in chronic wounds. Such treatments also could help reduce the risk of severe infections that sometimes lead to amputations, such as diabetic foot ulcers. Funded by the National Institutes of Health, the approach pairs long-known substances that do little ...

UMass researchers help ID new mineral on Mars, providing insight on the Red Planet’s potential to have supported life

2025-09-29

AMHERST, Mass. — Researchers from the University of Massachusetts Amherst are part of a team that has identified a unique mineral on Mars, described in Nature Communications. Named ferric hydroxysulfate, the mineral provides clues about the Martian environment and history of the planet, including the possibility of former lava, ash or hydrothermal activity. Mars gets its trademark red hue from the abundance of iron on its surface, but that’s just what can be seen with the naked eye. The various minerals on ...

UCSF assistant professor to receive the 2025 Dr. Nanette K. Wenger Research Goes Red® Award

2025-09-29

DALLAS, Sept 29, 2025 — Megan McLaughlin, M.D., M.P.H., an assistant professor of medicine in the division of cardiology at University of California, San Francisco (UCSF), has been selected to receive the 2025 Dr. Nanette K. Wenger Research Goes Red® Award at the American Heart Association’s Scientific Sessions 2025. The meeting, to be held Nov. 7-10, 2025, in New Orleans, is a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science. The award will be presented to Dr. McLaughlin during the annual Dr. Nanette K. Wenger Research Goes Red® Award for Best Scientific Article on Cardiovascular ...

Steel making could get a makeover

2025-09-29

Researchers investigate clean and efficient new method for iron production MINNEAPOLIS / ST. PAUL (09/29/2025) — A research team at the University of Minnesota Twin Cities has investigated a new method to produce iron, the main component of steel. For the first time, the researchers were able to observe chemical reactions and iron formation in real-time at the nanometer scale. This breakthrough has the potential to transform the global iron and steel production industry by improving energy efficiency ...

The rise in early-onset cancer in the US population— more apparent than real

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: