The rise in early-onset cancer in the US population— more apparent than real

JAMA Internal Medicine

2025-09-29

(Press-News.org) About The Study: The rise in early-onset cancer incidence does not consistently signal a rise in the occurrence of clinically meaningful cancer. While some of the increase in early-onset cancer is likely clinically meaningful, it appears small and limited to a few cancer sites. Much of the increase appears to reflect increased diagnostic scrutiny and over-diagnosis. Interpreting rising incidence as an epidemic of disease may lead to unnecessary screening and treatment while also diverting attention from other more pressing health threats in young adults.

Corresponding Author: To contact the corresponding author, H. Gilbert Welch, MD, MPH, email drgilwelch@gmail.com.

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(doi:10.1001/jamainternmed.2025.4917)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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The rise in early-onset cancer in the US population— more apparent than real

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