Overactive microRNAs block fat cell development in progeria
“The findings highlight miRNA-145-5p and miRNA-27b-3p as potential therapeutic targets to address adipose tissue defects and premature aging in HGPS”
2025-10-07
(Press-News.org)
“The findings highlight miRNA-145-5p and miRNA-27b-3p as potential therapeutic targets to address adipose tissue defects and premature aging in HGPS.”
BUFFALO, NY — October 7, 2025 — A new research paper was published in Volume 17, Issue 9 of Aging-US on August 27, 2025, titled, “Deregulated miR-145 and miR-27b in Hutchinson-Gilford progeria syndrome: implications for adipogenesis.”
In this study, led by first author Felix Quirin Fenzl and corresponding author Karima Djabali from the Technical University of Munich (TUM), researchers identified that miR-145-5p and miR-27b-3p interfere with the formation of fat cells in children with Hutchinson-Gilford progeria syndrome (HGPS), a rare and fatal premature aging disorder. Their findings help explain why patients often experience fat loss and related metabolic complications and suggest new potential therapeutic strategies.
Hutchinson-Gilford progeria syndrome is a genetic condition that causes rapid aging in children, often leading to early death due to heart disease. Although affected children appear healthy at birth, they soon develop signs of accelerated aging, including hair loss, stiff joints, and a significant reduction in fat tissue. While certain treatments can slow disease progression, many aspects, such as the loss of fat tissue, remain poorly understood.
“Overall, this study provides the first comprehensive miRNA profiling of HGPS and control fibroblasts across different stages of cellular senescence.”
This study focused on how microRNAs—tiny molecules that help regulate gene expression—contribute to the disease. To explore this, the researchers used skin-derived stem cells from both healthy individuals and HGPS patients. When they transformed these cells into fat cells, the HGPS-derived stem cells formed significantly fewer fat cells. This difference was linked to unusually high levels of miR-145-5p and miR-27b-3p. These molecules were found to silence important genes required for fat cell growth and function. When the researchers blocked these microRNAs, fat cell formation improved.
The team also examined fat tissue from a mouse model of HGPS. Similar to the human cells, these mice showed increased levels of miR-145-5p and miR-27b-3p and impaired fat development. These results confirm that these two microRNAs play a central role in the loss of fat tissue seen in the disease. Importantly, reducing their activity could become a promising therapeutic strategy for restoring fat tissue in affected individuals.
Although further research is needed before developing treatments, this study represents a step forward in understanding the molecular causes of lipodystrophy, a condition in which the body cannot form healthy fat tissue, in HGPS. It also opens the door for future therapies that could improve quality of life and health outcomes for patients. In the long term, similar approaches might benefit people with other metabolic diseases, such as obesity or diabetes, where fat cell function is also disrupted.
DOI: https://doi.org/10.18632/aging.206309
Corresponding author: Karima Djabali — djabali@tum.de
Abstract video: https://www.youtube.com/watch?v=b0ksC3cvdZ0
Keywords: aging, Hutchinson-Gilford progeria syndrome (HGPS), progerin, microRNAs, adipogenesis
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[Press-News.org] Overactive microRNAs block fat cell development in progeria
“The findings highlight miRNA-145-5p and miRNA-27b-3p as potential therapeutic targets to address adipose tissue defects and premature aging in HGPS”
