Rapid vs standard induction to injectable extended-release buprenorphine

JAMA Network Open

2025-10-14

(Press-News.org) About The Study: In this multicenter randomized clinical trial, rapid induction had higher retention than standard induction overall and in patients who tested positive for fentanyl through extended-release buprenorphine injection 2. Administration of injection 2 after 1 week was well tolerated and minimized time below target therapeutic levels of 2 ng/mL or greater compared with injection after 1 month.

Corresponding author: To contact the corresponding author, Robert L. Dobbins, M.D., Ph.D., email robert.dobbins@indivior.com.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi: 10.1001/jamanetworkopen.2025.37319)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Rapid vs standard induction to injectable extended-release buprenorphine

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