Study indicates dramatic increase in percentage of US adults who meet new definition of obesity

(Press-News.org) The prevalence of obesity in the United States could rise sharply under a new definition of obesity released earlier this year by the Lancet Diabetes and Endocrinology Commission. Researchers from Mass General Brigham found that when applying the new criteria, which expands upon the traditional use of body mass index (BMI) to include measures of body fat distribution, the prevalence of obesity increased from about 40 percent to about 70 percent among over 300,000 people included in their study. The rise was even more pronounced among older adults. Additionally, the researchers found that those newly added individuals also had a higher risk of adverse health outcomes. Their results are published in JAMA Network Open.

“We already thought we had an obesity epidemic, but this is astounding,” said co-first author Lindsay Fourman, MD, an endocrinologist in the Metabolism Unit in the Endocrinology Division of the Mass General Brigham Department of Medicine. “With potentially 70 percent of the adult population now considered to have excess fat, we need to better understand what treatment approaches to prioritize.”

Traditionally, obesity has been defined by BMI, which estimates body fat based on a person’s weight and height. But other anthropomorphic measures—such as waist circumference, waist-to-height ratio, or waist-to-hip ratio—may further account for fat distribution and aid in differentiation between muscle and fat mass.

Under the new framework, a person is classified as having obesity if they have a high BMI plus at least one elevated anthropometric measure (a condition the authors term “BMI-plus-anthropometric obesity”), or if they have a normal BMI and at least two elevated anthropometric measures (a condition termed “anthropometric-only obesity”). The new definition also distinguishes between preclinical and clinical obesity with clinical obesity defined as the presence of obesity-related physical impairment or organ dysfunction. At least 76 organizations have endorsed the new guidelines, including the American Heart Association and The Obesity Society.

The study analyzed participants in the National Institutes of Health All of Us Research Program’s cohort of over 300,000 Americans. Obesity prevalence was 68.6 percent with the new definition, versus 42.9 percent under the traditional BMI-based definition. This increase was entirely driven by inclusion of individuals with anthropometric-only obesity. Obesity rates varied by sex, race, and especially by age—affecting nearly 80 percent of adults over 70.

Importantly, the study found that those with anthropometric-only obesity – who would not have been classified as having obesity by the traditional definition – had a higher risk of diabetes, cardiovascular disease, and mortality than people without obesity. About half of all individuals who met the new obesity criteria had clinical obesity, and this proportion was only slightly lower in the anthropometric-only obesity group compared with the BMI-plus-anthropometric obesity group.

“We have always recognized the limitations of BMI as a single marker for obesity because it doesn't take into account body fat distribution,” said senior author Steven Grinspoon, MD, Chief of the Metabolism Unit in the Endocrinology Division of the Mass General Brigham Department of Medicine. “Seeing an increased risk of cardiovascular disease and diabetes in this new group of people with obesity, who were not considered to have obesity before, brings up interesting questions about obesity medications and other therapeutics.”

The researchers emphasize that further studies are needed to better understand the causes of and optimal treatments for anthropometric-only obesity. The research team previously developed a therapeutic that reduces waist circumference and plans to explore the utility of different treatment strategies in this newly defined population.

“Identifying excess body fat is very important as we’re finding that even people with a normal BMI but with abdominal fat accumulation are at increased health risk,” Fourman said. “Body composition matters – it’s not just pounds on a scale.”

Authorship: In addition to Fourman and Grinspoon, Mass General Brigham authors include Aya Awwad, Camille A. Dash, Julia E. Johnson, Allison K. Thistle, Nikhita Chahal, Sara L. Stockman, Mabel Toribio, Chika Anekwe, and Arijeet K. Gattu. Additional authors include Alba Gutiérrez-Sacristán.

Disclosures: Fourman serves as a consultant to Theratechnologies and Chiesi Farmaceutici and receives grant funding to her institution from Chiesi Farmaceutici outside of this work. Grinspoon serves as a consultant to Marathon Assets Management and Exavir Therapeutics and receives grant funding to his institution from Kowa Pharmaceuticals, Gilead Sciences, and Viiv Healthcare, unrelated to this project. For the remaining authors, no conflicts were declared.

Funding: This work was supported by the National Institutes of Health (grants K23HD100266, 1R01AG087809, T32DK007028, K23HL147799, 1R01HL173028, and P30DK040561) as well as the American Heart Association-Harold Amos Medical Research Faculty Development Program, supported by the Robert Wood Johnson Foundation, and the Robert A. Winn Excellence in Clinical Trials Award Program from the Bristol Meyers Squibb Foundation. The funding organizations played no role in the design and conduct of the study, collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Paper cited: Fourman LT et al. “Implications of the Lancet Commission Obesity Definition Among the All of Us Cohort” JAMA Network Open DOI: 10.1001/jamanetworkopen.2025.37619 About Mass General Brigham

Mass General Brigham is an integrated academic health care system, uniting great minds to solve the hardest problems in medicine for our communities and the world. Mass General Brigham connects a full continuum of care across a system of academic medical centers, community and specialty hospitals, a health insurance plan, physician networks, community health centers, home care, and long-term care services. Mass General Brigham is a nonprofit organization committed to patient care, research, teaching, and service to the community. In addition, Mass General Brigham is one of the nation’s leading biomedical research organizations with several Harvard Medical School teaching hospitals. For more information, please visit massgeneralbrigham.org.

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