PFAS exposure and endocrine disruption among women

JAMA Network Open

2025-12-05

(Press-News.org) About The Study: Data from this cross-sectional study show that exposure to single and mixtures of perfluoroalkyl and polyfluoroalkyl substances (PFAS) was associated with higher odds of endocrine disruption (ED) among women. The findings demonstrated that certain PFAS compounds, particularly n-PFOS, were associated with ED. PFAS are widely used in industry, and increasing evidence suggests that even low-level, chronic exposure may disrupt endocrine function and harm health. Exposure to mixtures of PFAS remained positively associated with developing ED.

Corresponding Author: To contact the corresponding author, Rezaul Karim Ripon, BPHD, SM, email rripon@hsph.harvard.edu.

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(doi:10.1001/jamanetworkopen.2025.39425)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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PFAS exposure and endocrine disruption among women

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