Researchers discover genetic link to Barrett’s esophagus offering new hope for esophageal cancer patients

(Press-News.org) CLEVELAND—Case Western Reserve University researchers have made a significant breakthrough in understanding Barrett’s esophagus, a precancerous condition that dramatically increases the risk of developing esophageal adenocarcinoma, one of the fastest-spreading and deadliest forms of cancer.

In a new study, they’ve discovered how inherited genetic abnormalities increase the chance of developing Barrett's esophagus by weakening the esophageal lining, making it more susceptible to harm caused by stomach bile acid.

Barrett’s esophagus occurs when the normal lining of the food pipe (the tube connecting your mouth to your stomach) is replaced by specialized cells usually present in the intestinal lining. This condition affects about 5% of the population nationally—especially those with chronic heartburn, according to the National Institute of Diabetes and Digestive and Kidney Diseases.

But the molecular factors responsible for the onset of Barrett’s esophagus remain poorly understood.

The findings, published in Nature Communications, combined family studies, laboratory experiments and genetically engineered mouse models to identify and understand how genetic defects contribute to disease development.

The team sequenced and analyzed genetic material of 684 people from 302 families where multiple members developed Barrett’s esophagus or esophageal cancer. They discovered that a subset of affected family members carry inherited mutations in a gene called VSIG10L.

“We found that this gene acts like a quality control system for the esophageal lining,” said lead researcher Kishore Guda, associate professor in the Department of Pathology and GMS-Oncology at the Case Western Reserve School of Medicine. “When it’s defective, the cells do not mature properly and the protective barrier in the esophageal lining becomes weak, allowing stomach bile acid to cause tissue changes that enhances the risk of developing Barrett’s esophagus.”

When researchers genetically engineered mice with human-equivalent VSIG10L mutations, they found that the esophageal lining became disrupted structurally and molecularly, according to Guda, also a member of the Case Comprehensive Cancer Center at the Digestive Health Research Institute. The study found that when the mice were exposed to bile acid, they developed Barrett’s-like disease over time, effectively replicating the disease’s progression in humans.

These genetically engineered mice also represent the first animal model for Barrett’s esophagus based directly on human genetic predisposition to the disease, Guda said.

With VSIG10L shown to be a key gene in maintaining esophageal health, family members can now be screened for genetic variants to identify those at a high-risk of developing Barrett’s esophagus or esophageal cancer.

Case Western Reserve has been a global leader in research on gastrointestinal oncology, with a long-standing history of clinically impactful discoveries on the genetic causes of colorectal and gastroesophageal cancers. The university was also the first to identify a genetic predisposition to Barrett’s esophagus and esophageal adenocarcinoma. If left untreated, these cancers can spread to other parts of the body.

“Knowledge gained from studying such familial aspects of disease will enable us to rapidly translate these findings into the clinic,” Guda said. “We can now conduct early screenings and develop preventative strategies before the disease develops, ultimately restoring patients’ quality of life and curtailing cancer deaths. In addition to enabling a deeper understanding on the molecular basis of Barrett’s esophagus, our findings have important implications in other tissue and disease contexts where VSIG10L is relevant”.

                                                                        ###

About Case Western Reserve University

As one of the fastest-growing research universities in the United States, Case Western Reserve University is a force in career-defining education and life-changing research. Across our campus, more than 12,000 students from around the world converge to seek knowledge, find solutions and accelerate their impact. They learn from and collaborate with faculty members renowned for expertise in medicine, engineering, science, law, management, dental medicine, nursing, social work, and the arts. And with our location in Cleveland, Ohio—a hub of cultural, business and healthcare activity—our students gain unparalleled access to academic, research, clinical and entrepreneurial opportunities that prepare them to join our network of more than 125,000 alumni worldwide. Visit case.edu to see why Case Western Reserve University is built for those driven to be a force in the world.

END