Tobacco smoking impacts teens' brains, UCLA study shows

(Press-News.org) Tobacco smoking is the leading preventable cause of death and disease in the U.S., with more than 400,000 deaths each year attributable to smoking or its consequences. And yet teens still smoke. Indeed, smoking usually begins in the teen years, and approximately 80 percent of adult smokers became hooked by the time they were 18. Meanwhile, teens who don't take up smoking usually never do.

While studies have linked cigarette smoking to deficits in attention and memory in adults, UCLA researchers wanted to compare brain function in adolescent smokers and non-smokers, with a focus on the prefrontal cortex, the area of the brain that guides "executive functions" like decision-making and that is still developing structurally and functionally in adolescents.

They found a disturbing correlation: The greater a teen's addiction to nicotine, the less active the prefrontal cortex was, suggesting that smoking can affect brain function.

The research appears in the current online edition of the journal Neuropsychopharmacology.

The finding is obviously not good news for smokers, said the study's senior author, Edythe London, a professor of psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA.

"As the prefrontal cortex continues to develop during the critical period of adolescence, smoking may influence the trajectory of brain development and affect the function of the prefrontal cortex," London said.

In the study, 25 smokers and 25 non-smokers between the ages of 15 to 21 were asked to perform a test that activated the prefrontal cortex and required them to inhibit responding. The test, called the Stop-Signal Task (SST), was done while the participants were undergoing functional magnetic resonance imaging (fMRI). The Stop-Signal Task involves pressing a button as quickly as possible every time a lighted arrow appears — unless an auditory tone is played, in which case the participant must prevent himself from pressing the button. It is a test of a person's ability to inhibit an action.

Prior to the fMRI test, the researchers used the Heaviness of Smoking Index (HSI) to measure the level of nicotine dependence in the smoking group. The HSI takes into account how many cigarettes a teen smokes in a day and how soon after waking he or she takes the first smoke.

The results of the tests, London said, were interesting — and surprising. Among smokers, the researchers found that the higher the HSI — that is, the more a teen smoked — the lesser the activity in the prefrontal cortex. And yet, despite these lower levels of activation, the smoking group and the non-smoking group performed roughly the same with respect to inhibition on the Stop-Signal Task.

"The finding that there was little difference on the Stop-Signal Task between smokers and non-smokers was a surprise," said London, who is also a professor of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA and a member of the UCLA Brain Research Institute. "That suggested to us that the motor response of smokers may be maintained through some kind of compensation from other brain areas."

Protracted development of the prefrontal cortex has been implicated as a cause of poor decision-making in teens, London said, caused by immature cognitive control during adolescence.

"Such an effect can influence the ability of youth to make rational decisions regarding their well-being, and that includes the decision to stop smoking," she said.

The key finding, London noted, is that "as the prefrontal cortex continues to develop during the critical period of adolescence, smoking may influence the trajectory of brain development, affecting the function of the prefrontal cortex. In turn, if the prefrontal cortex is negatively impacted, a teen may be more likely to start smoking and to keep smoking — instead of making the decision that would favor a healthier life."

On the other hand, the fact that adolescent smokers and non-smokers performed equally well during a response-inhibition test suggests that early interventions during the teen years may prevent the transition from a teen smoking an occasional cigarette in response to peer pressure to addiction in later adolescence.

### In addition to London, study authors included lead author Adriana Galván, Christine M. Baker and Kristine M. McGlennen of UCLA, and Russell A. Poldrack, of the University of Texas at Austin.

Funding for this study was provided by Philip Morris USA, an endowment from the Thomas P. and Katherine K. Pike Chair in Addiction Studies, and a gift from the Marjorie M Greene Trust. None of the sponsors had any involvement in the design, collection, analysis or interpretation of data, the writing the manuscript, or the decision to submit the manuscript for publication.

The Semel Institute for Neuroscience and Human Behavior is an interdisciplinary research and education institute devoted to the understanding of complex human behavior, including the genetic, biological, behavioral and sociocultural underpinnings of normal behavior, and the causes and consequences of neuropsychiatric disorders. In addition to conducting fundamental research, the institute faculty seeks to develop effective strategies for prevention and treatment of neurological, psychiatric and behavioral disorder, including improvement in access to mental health services and the shaping of national health policy.

For more news, visit the UCLA Newsroom and follow us on Twitter.