PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Fuz is essential for craniofacial and tooth development

2011-03-18
(Press-News.org) San Diego, Calif., USA – Today, during the 89th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 40th Annual Meeting of the American Association for Dental Research and the 35th Annual Meeting of the Canadian Association for Dental Research, lead researcher Z. Zhang will hold an oral presentation on a study titled "Fuz is Essential for Craniofacial and Tooth Development." Fuz has been identified as a planar cell polarity effector gene and shown to be involved in ciliogenesis.

The objective of this study was to determine if fuz expression was critical for craniofacial and tooth development. In this study, fuz-/- mutant mice and mouse embryo fibroblasts were used to analyze the effect of fuz expression on tooth development and gene expression pathways, respectively. Immunohistochemical, molecular and biochemical assays were used to understand the defects and molecular mechanisms underlying the phenotype of the Fuz-/- mice.

The Fuz-/- mutant mice exhibited massive craniofacial deformities such as a hypoplastic mandible, a complete lack of upper and lower incisor development, malformed molars, hyperplastic Meckel's cartilage and missing eyes and tongue. Fuz has an essential role in ciliogenesis, and the primary cilium has been shown to repress canonical Wnt signaling. The results of the data collected suggests that Fuz is involved in a negative feedback loop of canonical Wnt signalling regulation, and this feedback loop is essential for precise regulation of craniofacial development. Support for this research was provided from grant DE13941 from the National Institute of Dental and Craniofacial Research.

###

This is a summary of abstract #247, "Fuz Is Essential For Craniofacial and Tooth Development," to be presented by Z. Zhang on Thursday, March 17, 2011, 8 a.m. - 9:30 a.m. in room 11B of the San Diego Convention Center.

About the International Association for Dental Research

The International Association for Dental Research (IADR) is a nonprofit organization with more than 12,000 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge to improve oral health, (2) supporting the oral health research community, and (3) facilitating the communication and application of research findings for the improvement of oral health worldwide.

To learn more about IADR, visit www.iadr.org.

END



ELSE PRESS RELEASES FROM THIS DATE:

Virtual conversation simulator found beneficial for adults with autism

Virtual conversation simulator found beneficial for adults with autism
2011-03-18
New Rochelle, NY, March 17, 2011—Simulated interactions in which adults with autism converse with a virtual partner may help them develop better social interaction skills, according to a novel study presented in Cyberpsychology, Behavior, and Social Networking, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com). The article is available free online at http://www.liebertpub.com/cyber More than half of individuals diagnosed with autism have normal intellectual capabilities yet struggle in social and work environments because of their severely ...

Product choice: Why do consumers misestimate their abilities?

2011-03-18
Even if you have a grasp on your own abilities, you might have trouble estimating the abilities of others, according to a new study in the Journal of Consumer Research. These false impressions affect people's product choices. "We've known that people overestimate their relative ability for seemingly easy tasks, like driving, and underestimate for difficult tasks," write authors Andrew D. Gershoff (University of Texas at Austin) and Katherine A. Burson (University of Michigan). The researchers found that people tend to think others are fairly evenly spread out in their ...

Stem cells may be key to understanding the origins of colon cancer and detecting relapse

2011-03-18
Colorectal cancer cells trigger a set of genes similar to those found in intestinal stem cells, scientists at the Institute for Research in Biomedicine (IRB Barcelona) have found. The team of researchers, led by ICREA researcher Eduard Batlle, propose that patients with colorectal cancer undergo genetic tests of their intestinal epithelium in order to predict a higher risk of relapse. The results of the study, published online this week in Cell Stem Cell, offer new possibilities for diagnosing and treating the disease. Colon cancer is the second cause of death by cancer ...

ATS issues joint statement on the treatment of idiopathic pulmonary fibrosis

2011-03-18
The American Thoracic Society has released new official clinical guidelines on the diagnosis and management of idiopathic pulmonary fibrosis (IPF). The statement replaces ATS guidelines published in 2000, and reviews current knowledge in the epidemiology, etiology, diagnosis and management of IPF, as well as available treatment options, including pharmacologic and non-pharmacologic therapies and palliative care. The statement appears in the March 15, 2011, American Journal of Respiratory and Critical Care Medicine. IPF is a chronic, progressive, fatal form of fibrotic ...

What does signing your name mean in the marketplace?

2011-03-18
Signing your name on the dotted line heightens your sense of self and leads to purchase behavior that affirms your self-identity, according to a new study in the Journal of Consumer Research. But signing can reduce engagement in consumers who don't identify strongly with a product or category. "Although there are numerous ways in which people may present their identity to others, signing one's name has distinct legal, social, and economic implications," write authors Keri L. Kettle and Gerald Häubl (University of Alberta). The act of signing also has implications in the ...

Sealing manifest occlusal caries in permanent teeth -- 2.5-year results

2011-03-18
San Diego, Calif., USA – Today, during the 89th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 40th Annual Meeting of the American Association for Dental Research and the 35th Annual Meeting of the Canadian Association for Dental Research, lead researcher V. Qvist will hold an oral presentation on a research study titled "Sealing Manifest Occlusal Caries in Permanent Teeth - 2½-year Results." This research was performed under the objective of investigating the possibility of non-operative sealing of manifest ...

Intervention offers 'best chance' to save species endangered by climate change

2011-03-18
A University of York scientist is proposing a radical programme of 'assisted colonisation' to save species endangered by climate change. Chris Thomas, Professor of Conservation Biology, says the strategy is applicable across the world, and he suggests Britain as a potential haven for species such as the Iberian lynx, the Spanish Imperial Eagle, the Pyrenean Desman and the Provence Chalkhill Blue butterfly. In an opinion paper in Trends in Ecology and Evolution, Professor Thomas, of the University's Department of Biology, says that moving endangered species is the only ...

Buying a new product: When is it better to ask a novice rather than an expert?

2011-03-18
If you're considering a purchase, you might want to avoid asking an expert's advice. According to a new study in the Journal of Consumer Research, experts have a hard time recalling product features—especially if they feel they need to explain their logic. "People tend to assume that knowledge is always a good thing, but our research suggests that in some cases this may not be true," write authors Ravi Mehta (University of Illinois, Urbana-Champaign), JoAndrea Hoegg (University of British Columbia), and Amitav Chakravarti (New York University). The researchers evaluated ...

Smart phones not replacing other media for news access -- at least yet

2011-03-18
COLUMBUS, Ohio – In a first-of-its-kind study, researchers found that mobile media technologies such as smart phones aren't taking people away from relying on traditional media sources such as newspapers or television. Instead, mobile media are filling the spaces in people's daily routine in which other media sources are either unavailable or inconvenient to use. That suggests mobile media use is taking a different path to popularity than did technologies like television, said John Dimmick, lead author of the study and professor of communication at Ohio State University. "Typically, ...

Scientists ID possible biomarker to gauge Alzheimer's prognosis, effect of therapies

2011-03-18
UCLA researchers have identified a new biomarker that could help them track how effectively the immune system is able to clear the brain of amyloid beta, which forms the plaques considered one of the hallmarks of Alzheimer's disease. The pilot study, currently published online in the Journal of Alzheimer's Disease, demonstrates how the immune gene MGAT3, which is essential in clearing amyloid beta, is expressed differently in different Alzheimer's patients. The finding may be useful in providing more highly individualized disease prognoses in the future. It may also ...

LAST 30 PRESS RELEASES:

Knee-d for excellence: New regional training hub keeps surgeons sharp for ageing population

The Lancet: Billions lack access to healthy diets as food systems drive climate and health crises, but sustainable, equitable solutions are within reach, says new EAT-Lancet report

Countries with highest reported levels of hearing loss have lowest use of hearing aids

Early medical abortion at home up to 12 weeks is safe, effective, and comparable to hospital care

New approach to gravitational wave detection opens the Milli-Hz Frontier

Rice membrane extracts lithium from brines with greater speed, less waste

Exercise lowers disease risk. This researcher wants to understand how

Hurricane evacuation patterns differ based on where the storm hits

Stem Cell Reports welcomes new members to its Editorial Board

Researchers develop molecular qubits that communicate at telecom frequencies

Mayo Clinic awarded up to $40 million by ARPA-H for pioneering air safety research

People with Down syndrome have early neuroinflammation

CNIO researchers create the “human repairome”, a catalogue of DNA “scars” that will help define personalized cancer treatments

Strengthening biosecurity screening for genes that encode proteins of concern

Global wildfire disasters are growing in frequency and cost

Wildfire management: Reactive response and recovery, or proactive mitigation and prevention

Phosphine detected in the atmosphere of a low-temperature brown dwarf

Scientists develop rapid and scalable platform for in planta directed evolution

New tiny prehistoric fish species unlocks origins of catfish and carp

Plant microbiota: War and peace under the surface

Fossilized ear bones rewrite the history of freshwater fish

Detection of phosphine in a brown dwarf atmosphere raises more questions

USF study: Ancient plankton hint at steadier future for ocean life

MIT researchers find a simple formula could guide the design of faster-charging, longer-lasting batteries

Towards efficient room-temperature fluorine recovery from fluoropolymers

Mapping RNA-protein 'chats' could uncover new treatments for cancer and brain disease

The hidden burden of solitude: How social withdrawal influences the adolescent brain

Kidney disease study reveals unexpected marker

AI wrote nearly a quarter of corporate press releases in 2024

The ‘big bad wolf’ fears the human ‘super predator’ – for good reason

[Press-News.org] Fuz is essential for craniofacial and tooth development