In vitro infection and replication of hepatitis E virus in human hepatocytes

Innovation in science

2011-04-03

(Press-News.org) Groundbreaking data presented today demonstrates, for the first time, in vitro infection and replication of swine hepatitis E virus (HEV) in human hepatocytes.1

This study also verifies that HEV is a zoonosis (infectious disease that can be transmitted from animals to humans), which has been suggested for a long time.

HEV is a major cause of epidemic and acute sporadic hepatitis in many developing countries. It is also endemic in many industrialized countries, including the United States, European countries and Japan.

Four major genotypes (genotypes 1-4) of HEV have been identified in mammalian species. Genotype 3 and 4 HEVs are believed to undergo zoonotic transmission, with a reservoir in pigs and, possibly, a range of other mammals.

### References 1. Oshiro, Y. et al. In vitro infection and replication of hepatitis E virus in human hepatocytes. Abstract presented at The International Liver CongressTM 2011. http://www1.easl.eu/easl2011/program/Orals/416.htm

ELSE PRESS RELEASES FROM THIS DATE:

LateRooms.com - See John Godber's Bouncers in the Lake District

2011-04-03

The Theatre by the Lake is preparing to stage a new production of Bouncers, the acclaimed play by John Godber. People in the audience at the Keswick venue will be drawn into the world of Lucky Eric, Judd, Ralph and Les - the group of doormen who keep a watchful eye on proceedings at the Mr Cinders nightclub. The bouncers observe a number of colourful characters as they go about their business, with the action set against a backdrop of flashing disco lights and pulsating music. First staged in 1977, the drama is one of the West Yorkshire-born playwright's most enduringly ...

Mum’s the word when it comes to children’s happiness

2011-04-03

As part of the study, which will follow 40,000 UK households over a number of years, young people aged between 10 to 15 years have been asked how satisfied they are with their lives. The findings indicate that a mother's happiness in her partnership is more important to the child than the father's. The findings are based on a sample of 6,441 women, 5,384 men and 1,268 young people. Overall, 60 per cent of young people say they are 'completely satisfied' with their family situation but in families where the child's mother is unhappy in her partnership, only 55 per cent ...

PegIFN-lambda shows superior virological response and improved safety than PegIFN-alpha-2a

2011-04-03

Berlin, Germany, 02 April 2011: Highly exciting new data presented today at the International Liver CongressTM found Pegylated Interferon-lambda (PegIFN-lambda) shows superior virological response in HCV patients of genotypes 1-4, with improved safety and tolerability, compared to Pegylated Interferon-alpha (PegIFN-alpha-2a), the current standard of care in chronic HCV.1 The study results are so important because they show PegIFN-lambda could provide relief for the 20% of HCV patients who have to undergo dose reduction, or cease treatment, on PegIFN-alpha-2a – a part ...

LateRooms.com - Top Female Surfers Set for Sydney's Commonwealth Bank Beachley Classic

2011-04-03

The world's top female surfers will be heading to Sydney in the coming weeks to face off at the 2011 Commonwealth Bank Beachley Classic. Each of the Association of Surfing Professionals' (ASP's) top 17-ranked women will battle it out for a share of the AU$110,000 prize pot at the event. Among the stars set to compete are four-time world champion Stephanie Gilmore and up-and-coming world tour rookies Laura Enever and Tyler Wright. Gilmore is likely to start as one of the favourites, having taken last year's Beachley Classic title by beating fellow Australian Sally ...

Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment

2011-04-03

Berlin, Germany, Saturday 02 April 2011: Exciting new data presented today at the International Liver CongressTM 2011 show that quadruple therapy in chronic hepatitis C (HCV) patients suppressed the emergence of resistant variants and resulted in a 100% rate of sustained virological response - undetectable HCV RNA - 12 weeks after treatment (SVR12).1 In the quadruple therapy study, HCV patients were given four drugs in combination; pegylated Interferon-alpha (PegIFN-alpha); ribavirin (RBV); and two different direct-acting antivirals (DAAs) BMS-650032 (an HCV NS3 protease ...

Genetic variation cuts bladder cancer risk, protects chromosome tips

2011-04-03

ORLANDO - A common genetic variation links to both bladder cancer risk and to the length of protective caps found on the ends of chromosomes, scientists at The University of Texas MD Anderson Cancer Center reported today at the AACR 102nd Annual Meeting. These endings or tips, called telomeres, guard against chromosomal damage and genomic instability that can lead to cancer and other diseases. "We found a single point of variation in the genome strongly associated with a 19 percent decrease in bladder cancer risk. The same variant also is linked to longer telomeres, ...

LateRooms.com - Enter a Team in the Gold Coast Beach Soccer Challenge

2011-04-03

Sports fans will have the chance to put their beach soccer skills to the test in a tournament on the Gold Coast next month. The game may be relatively new to Australia but it has a huge following overseas, having first been played on the sandy stretches of Rio de Janeiro more than 30 years ago. Flamboyant former Manchester United and France star Eric Cantona's love of beach soccer has helped bring it to a global audience in over 170 countries, making it one of the world's fastest-growing sports. Youngsters and adults have been invited to enter their own teams in ...

Spring Means a Spring Clean with the Help of HSS Hire

2011-04-03

As spring begins, it is time to start clearing your garden of all the unwanted winter mess which has piled up over the previous months. It's not just the garden either, as the rest of your home is probably due a traditional 'spring clean', so why not let leading tool and equipment hire specialists, HSS Hire help you out? HSS Hire, the award-winning tool and equipment hire company, has an extensive range of items to help with a wide range of indoor and outdoor tasks. From carpet cleaners to lawnmowers, ladders to drills, HSS Hire is on hand to help. Starting outdoors ...

LateRooms.com - ASO Plays Miles Davis Tribute Coming to Adelaide

2011-04-03

The Adelaide Symphony Orchestra (ASO) will pay tribute to Miles Davis with two performances in the South Australia capital in May 2011. One of the most influential musicians of the 20th century, Davis was at the forefront of many major developments in jazz, including bebop, hard bop and jazz fusion. His ensembles also helped to launch the careers of many other well-known artists such as JJ Johnson, Kai Winding and Gerry Mulligan. Davis's career spanned 50 years, during which he released seminal albums like First Miles, Kind of Blue and Someday My Prince Will Come. Acclaimed ...

Antidepressants linked to thicker arteries

2011-04-03

Antidepressant use has been linked to thicker arteries, possibly contributing to the risk of heart disease and stroke, in a study of twin veterans. The data is being presented Tuesday, April 5 at the American College of Cardiology meeting in New Orleans. Depression can heighten the risk for heart disease, but the effect of antidepressant use revealed by the study is separate and independent from depression itself, says first author Amit Shah, MD, a cardiology fellow at Emory University School of Medicine. The data suggest that antidepressants may combine with depression ...

Older age, chronic kidney disease and cerebrovascular disease linked with increased risk for paralysis and death after West Nile virus infection

Liquid metal modified hexagonal boron nitride flakes for efficient electromagnetic wave absorption and thermal management

Failure mechanisms in PEM water electrolyzers

Study captures how cancer cells hide from brain immune cells, shows that removing their “don’t eat me” signals stops their escape

Persistent antibiotic resistance of cholera-causing bacteria in Africa revealed from a multinational workshop for strengthening disease surveillance

SwRI, Trinity University to synthesize novel compound to mitigate effects of stroke, heart attack

Novel endocrine therapy giredestrant improves disease-free survival over standard of care for patients with early-stage breast cancer in phase III lidERA trial

Gen Z views world as "scary place" with growing cynicism about ability to create change

[Press-News.org] In vitro infection and replication of hepatitis E virus in human hepatocytes
Innovation in science

In vitro infection and replication of hepatitis E virus in human hepatocytes

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: