(Press-News.org) Getting vaccinated against the flu lowers kidney transplant recipients' risk of organ loss and death, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that concerns about the safety of the influenza vaccine in transplant recipients are unwarranted.
Influenza can cause severe illness and even death in some individuals. Organ transplant recipients and those taking immunosuppressant medications face a particularly high risk of dying after being infected. Protection against the flu is especially important for these patients, but earlier reports have suggested that influenza vaccination might activate an immune response that could trigger rejection of transplanted organs. Some studies have also suggested that the immunosuppressant medications that transplant recipients take may decrease the effectiveness of the influenza vaccine.
To investigate these issues, Frank Hurst, MD (Walter Reed Army Medical Center and F. Edward Hebert School of Medicine) and his colleagues assessed Medicare claims for influenza vaccination and influenza infections in 51,730 adult Medicare patients first transplanted from January 2000 to July 2006 and were followed through October 2006. There were 9,678 (18.7%) patients who were vaccinated against the flu in the first year after transplantation. These individuals were 23% less likely to experience organ loss and 18% less likely to die during the study period than individuals who were not vaccinated. A total of 310 (0.6%) patients got the flu. They were no more likely to experience organ loss than patients who did not get the flu.
These findings do not support withholding immunization on the basis of concerns that the influenza vaccine could negatively affect transplanted organs. The authors noted, however, that no data are currently available to prove that influenza vaccination actually prevents the flu in transplant recipients.
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Study co-authors include Jessica Lee, MD, Kevin Abbott, MD (Walter Reed Army Medical Center and F. Edward Hebert School of Medicine); Rahul Jindal, MD, PhD (Walter Reed Army Medical Center); and Lawrence Agodoa, MD (National Institutes of Health).
Disclosures: The authors reported no financial disclosures.
Disclaimer: The views expressed in this paper are those of the authors and do not reflect the official policy of the National Institutes of Health, the Department of Army, the Department of Defense, or the United States government.
The article entitled, "Outcomes Associated with Influenza Vaccination in the First Year after Kidney Transplantation," will appear online at http://cjasn.asnjournals.org/ on April 28, 2011, doi 10.2215/CJN.05430610.
The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.
Founded in 1966, and with more than 12,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.
Green light for flu vaccine in transplant recipients
Vaccination is safe and lowers risk of organ loss and death
2011-04-29
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[Press-News.org] Green light for flu vaccine in transplant recipientsVaccination is safe and lowers risk of organ loss and death