Study finds Filipino children in San Diego County at higher risk for Kawasaki disease

(Press-News.org) While children of all ethnicities can contract Kawasaki disease (KD), a study led by researchers at the Kawasaki Disease Research Center at the University of California, San Diego and Rady Children's Hospital-San Diego finds that Filipino children with KD are at a higher risk for inflammation of the blood vessels of the heart than those of other Asian and non-Asian backgrounds. Nearly 24 percent of Filipino children with KD in San Diego County were found to have aneurysms compared to 10.5 percent of children of other Asian descent.

The study appears in the May 6, 2011 issue of Pediatric Infectious Disease Journal.

"Filipinos make up the largest Asian subgroup in San Diego County, yet there are no available reports of KD in Filipino children," said Adriana H. Tremoulet, MD, MAS, assistant professor, Department of Pediatrics, UC San Diego School of Medicine. "With the results of this study, our call to action is for medical providers to have a heightened awareness of KD so patients can be treated promptly and the risk of heart disease is minimized. Parents, especially those of Filipino descent, need to know the signs and symptoms of KD and when to contact their physician."

Clinical signs of KD include fever, rash, red eyes, swollen glands in the neck, swollen and red hands and feet and red, cracked lips. If left untreated, one in four children will develop permanent damage to their blood vessels and heart.

The team analyzed 345 patients in San Diego Country who had KD. They collected clinical and demographic data across three groups – Filipino, non-Filipino Asians and others.

"Our findings indicate there may be genetic reasons why there is a higher attack rate of KD and aneurysms in Filipino children," said Tremoulet. "Our next steps are to increase awareness of KD in the Filipino community and to understand the genetic reasons why Filipino children are at higher risk of more severe KD."

### In addition to Tremoulet, the research team includes Gemmie Devera, MS, MPH, Brookie M. Best, PharmD, MAS, Skaggs School of Pharmacy and Pharmaceutical Sciences; Susan Jimenez-Fernandez, MD, Department of Pediatrics; Xiaoying Sun, MS, Department of Family and Preventive Medicine; Sonia Jain, PhD, Department of Family and Preventive Medicine; and Jane C. Burns, MD, Department of Pediatrics.

Funding was provided in part by grants from the National Heart, Lung and Blood Institution and the National Institute of Child Health and Human Development.

The Kawasaki Disease Research Center at UC San Diego: The Kawasaki Disease Research Program is a joint collaboration between the Departments of Pediatrics and Sociology at UC San Diego, the Scripps Institute of Oceanography and Rady Children's Hospital-San Diego, a research affiliate of UC San Diego School of Medicine.

In San Diego County, 30-40 children per 100,000 children less than five years of age are affected each year. More than 90 new patients are treated annually at Rady Children's Hospital, San Diego for KD. The illness is four to five times more common than some more publicly recognized diseases of children, such as tuberculosis or bacterial meningitis.

For more information visit: www.pediatrics.ucsd.edu/kawasaki