PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Community-based treatment of malaria, pneumonia could save lives, BU study finds

2010-09-22
(Press-News.org) Anti-malarial drugs are being used inappropriately for sick children in Zambia with fevers and difficulty breathing – a problem that can be addressed by arming community health workers with a simple rapid-diagnostic test and a supply of antibiotics, a study led by a team of Boston University School of Public Health [BUSPH] researchers has found.

In the study, published online Sept. 21 in PLoS Medicine, the research team from the Center for Global Health and Development at BUSPH addressed the widespread practice of treating children with fevers with anti-malarial drugs, rather than screening them first for malaria or pneumonia -- the two leading causes of death among children under age 5 in sub-Saharan Africa.

The researchers found that allowing community health workers to use a diagnostic test for malaria, before prescribing treatment, "resulted in a significant increase in the proportion of appropriately timed antibiotic treatments for non-severe pneumonia, and in a significant decrease in inappropriate use of anti-malarials."

The health workers were trained to give amoxicillin to children with suspected pneumonia.

Traditionally in Zambia, as in other parts of sub-Sahara Africa, most children who are brought to health personnel with fevers are treated with anti-malarials, and those with suspected pneumonia are referred to health facilities. That practice leads to the overuse of artemisinin–based anti-malarial drugs, while also delaying care for children suffering from pneumonia, some who live far from the nearest health facility. In addition, public health experts worry that overprescribing of artemisinin-based drugs could lead to widespread resistance to the medications.

"Pneumonia and malaria, two of the leading causes of morbidity and mortality among children under five in Zambia, often have overlapping clinical manifestations," the authors said. "This study has demonstrated the feasibility and effectiveness of using [community health workers] to provide integrated management of pneumonia and malaria at the community level."

The research team, led by Kojo Yeboah-Antwi, assistant professor of international health at BUSPH, studied treatment outcomes for more than 3,000 children, ages 6 months to 5 years, who presented with fevers, and in some cases fast respiratory rates, at community health posts. The children were randomized into two groups -- an intervention group, in which health workers used the rapid diagnostic tests and doses of amoxicillin; and a control group, in which the workers gave children anti-malarial drugs or referred those with suspected pneumonia to health facilities, in accordance with Zambian Ministry of Health policy.

The study found no significant difference in the overall treatment failure rates for children in the two groups. But it did find that the proportion of children who were given anti-malarial drugs was much higher in the control group than in the intervention group -- 99.1 percent, vs. 27.5 percent – suggesting that many of the children in the control group who were given such drugs did not need them.

Similarly, 68 percent of children in the intervention group who were classified as having pneumonia received early and appropriate treatment with antibiotics, compared to just 13 percent in the control group. That five-fold increase in the timely treatment of pneumonia was easily achieved by the trained community workers, the researchers said.

The study noted that more than 20 percent of children in the control group who were referred to health centers for suspected pneumonia did not comply with the referral.

"Providing [community health workers] with the means to treat malaria, but not pneumonia, increases the risk of treatment delay and progression to more severe disease for children with pneumonia," the researchers said.

They said the study's findings bolster the idea that community health workers in rural, remote areas can and should be trained to diagnose and treat common childhood illnesses.

"The integrated management of common childhood illnesses by community health workers is an important component of strengthening health systems in countries in sub-Saharan Africa that will help these countries attain an important Millenium Development goal – a reduction of child mortality by two-thirds by 2015," relative to 1990 levels, said Dr. David Hamer, a co-author of the study and professor of international health at the Center for Global Health and Development.

INFORMATION:

The study was funded by the U.S. Agency for International Development and the President's Malaria Initiative.

Other authors of the study include: Katherine Semrau, Lora Sabin, Donald Thea, William Macleod and Phil Seidenberg of the Center for Global Health and Development at BUSPH; Portipher Pilingana and Kazungu Siazeele of the Chikankata Mission Hospital, Zambia; Penelope Kalesha of the Zambian Ministry of Health, Child Health Unit; Busiku Hamainza of the National Malaria Control Center, Ministry of Health, in Zambia; Arthur Mazimba of the Center for International Health and Development-Zambia; and Karen Kamholz of the BU School of Medicine, Department of Pediatrics.

A video of the researchers discussing the study is available at: http://www.youtube.com/watch?v=dd1gBsmIIlE

The full study is available at: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000340

END



ELSE PRESS RELEASES FROM THIS DATE:

College students want more information about native wildflowers

College students want more information about native wildflowers
2010-09-22
GAINESVILLE, FL—A new trend shows native wildflowers are becoming more popular with consumers. The wildflower seed industry has experienced gains in popularity over the past 30 to 40 years and is considered to be a maturing, highly competitive market. In Florida, for example, a 2005 survey estimated sales of native plants in the state totaled almost $316 million. College students do not fit the traditional demographic profile of gardening and landscaping consumers, but today's horticulture students are tomorrow's decisionmakers—those who will determine how and if native ...

Brain cell communication: Why it's so fast

2010-09-22
The brain uses biochemical signal molecules Nowadays the biochemical language of the nerve cells is the subject of intensive research right down at the molecular level, and for the first time researchers, some from the University of Copenhagen, have described just how nerve cells are capable of transmitting signals practically simultaneously. The cells of the nervous system communicate using small molecule neurotransmitters such as dopamine, serotonin and noradrenalin. Dopamine is associated with cognitive functions such as memory, serotonin with mood control, and ...

New collaborative process can help improve management of marine recreational fisheries

2010-09-22
Solomons, Md. (September 21, 2010) – In an era when fisheries management is rife with controversy, new research led by a team of University of Maryland Center for Environmental Science fisheries scientists shows that a new, stakeholder-driven process can improve the way we manage fisheries targeted by both commercial and recreational interests. In the September issue of the journal Fisheries, the team documents how this innovative process resulted in more content stakeholders while implementing more conservative harvest measures for the king mackerel fishery in the ...

Hormone oxytocin improves social cognition but only in less socially proficient individuals

2010-09-22
Researchers at Mount Sinai School of Medicine have found that the naturally-occurring hormone oxytocin selectively improves social cognitive abilities for less socially proficient individuals, but has little effect on those who are more socially proficient. The study was published today in Psychological Science. Researchers at the Seaver Autism Center for Research and Treatment at Mount Sinai School of Medicine and Columbia University wanted to determine if oxytocin, popularly dubbed the "hormone of love," could have widespread benefit in making us more understanding ...

Savvy consumers put a high price on food safety

2010-09-22
EAST LANSING, Mich. — In the last two weeks, news media have covered stories on an Angus beef recall, oil-tainted Gulf shrimp and salmonella-infected eggs. Anecdotal evidence suggests that such headlines affect consumer spending. New research from Michigan State University demonstrates how these announcements indeed cause consumers as well as food industry professionals to make purchasing decisions. Consumers are not only quite attuned to food safety issues, but they also have significantly changed their shopping habits because of them, according to Chris Peterson, ...

Parting the waters: Computer modeling applies physics to Red Sea escape route

Parting the waters: Computer modeling applies physics to Red Sea escape route
2010-09-22
BOULDER--The biblical account of the parting of the Red Sea has inspired and mystified people for millennia. A new computer modeling study by researchers at the National Center for Atmospheric Research (NCAR) and the University of Colorado at Boulder (CU) shows how the movement of wind as described in the book of Exodus could have parted the waters. The computer simulations show that a strong east wind, blowing overnight, could have pushed water back at a bend where an ancient river is believed to have merged with a coastal lagoon along the Mediterranean Sea. With the ...

Mixed-use neighborhoods reduce some violent crimes, study says

2010-09-22
COLUMBUS, Ohio – Mixed-use neighborhoods that combine residential and business development may help lead to lower levels of some types of violent crime, a new study suggests. The results were just as true in impoverished neighborhoods as they were in more affluent areas, offering one possible way of improving blighted areas, according to the researchers. But the findings come with an important caveat. In a sparsely populated neighborhood, increases in business-residential density actually leads to higher levels of violent crimes, at least for a while. However, after ...

VP, university leaders discuss ARRA impact on research

2010-09-22
WASHINGTON, D.C. – The presidents of six leading research universities and two higher-education associations joined Vice President Joe Biden and White House science advisor Dr. John Holdren this morning to discuss the scientific research and related activities that have been made possible by the American Recovery and Reinvestment Act (ARRA). Participating in the event held in the Roosevelt Room of the White House were France Córdova, president, Purdue University; Ron Daniels, president, The Johns Hopkins University; Elson Floyd, president, Washington State University; ...

Research sheds light on altruism

2010-09-22
EAST LANSING, Mich. — Using digital evolution techniques that give scientists the ability to watch evolution in action, Michigan State University researchers have shed new light on what it is that makes species altruistic. Defined as the ability to sacrifice yourself for the sake of others, altruism has been a bit of a genetic mystery. Understanding why altruism evolves is one of the fundamental challenges in evolutionary theory. However, a paper published online in the journal Proceedings of the Royal Society B by researchers affiliated with MSU's BEACON Center for ...

China's environmental challenges have global implications

2010-09-22
EAST LANSING, Mich. --- Unlike Vegas, what happens in China doesn't stay in China. The country's environmental challenges have worldwide implications, so more developed nations, such as the United States, need to help China adopt integrated solutions for the sake of global sustainability, a Michigan State University environmental scientist argues. "What happens in China affects the rest of the world," said Jianguo "Jack" Liu, University Distinguished Professor of fisheries and wildlife. Liu is known around the world for his work on environmental sustainability and coupled ...

LAST 30 PRESS RELEASES:

First-in-human trial shows promising results for DLL3-targeted antibody-drug conjugate SHR-4849 in relapsed small cell lung cancer

Ifinatamab deruxtecan demonstrates high response rate in previously treated extensive-stage small cell lung cancer: Phase 2 IDeate-Lung01 trial

Higher blood pressure in childhood linked to earlier death from heart disease in adulthood

AI helped older adults report accurate blood pressure readings at home

High blood pressure in childhood and premature cardiovascular disease mortality

Zidesamtinib shows durable responses in ROS1 TKI pre-treated NSCLC, including patients with CNS disease and ROS1 G2032R mutations

Crizotinib fails to improve disease-free survival in resected early-stage ALK+ NSCLC

Ivonescimab plus chemotherapy improves progression-free survival in patients with EGFR+ NSCLC following 3rd-generation EGFR-TKI therapy

FLAURA2 trial shows osimertinib plus chemotherapy improves overall survival in eGFR-mutated advanced NSCLC

Aumolertinib plus chemotherapy improves progression-free survival in NSCLC with EGFR and concomitant tumor suppressor genes: ACROSS 2 phase III study

New antibody-drug conjugate shows promising efficacy in EGFR-mutated NSCLC patients

Iza-Bren in combination with osimertinib shows 100% response rate in EGFR-mutated NSCLC, phase II study finds

COMPEL study shows continuing osimertinib treatment through progression with the addition of chemotherapy improves progression-free survival in EGFR-mutated NSCLC

CheckMate 77T: Nivolumab maintains quality of life and reduces symptom deterioration in resectable NSCLC

Study validates AI lung cancer risk model Sybil in predominantly Black population at urban safety-net hospital

New medication lowered hard-to-control high blood pressure in people with chronic kidney disease

Innovative oncolytic virus and immunotherapy combinations pave the way for advanced cancer treatment

New insights into energy metabolism and immune dynamics could transform head and neck cancer treatment

Pennington Biomedical’s Dr. Steven Heymsfield named LSU Boyd Professor – LSU’s highest faculty honor

Study prompts new theory of human-machine communication

New method calculates rate of gene expression to understand cell fate

Researchers quantify rate of essential evolutionary process in the ocean

Innovation Crossroads companies join forces, awarded U.S. Air Force contract

Using new blood biomarkers, USC researchers find Alzheimer’s disease trial eligibility differs among various populations

Pioneering advances in in vivo CAR T cell production

Natural medicines target tumor vascular microenvironment to inhibit cancer growth

Coral-inspired pill offers a new window into the hidden world of the gut

nTIDE September2025 Jobs Report: Employment for people with disabilities surpasses prior high

When getting a job makes you go hungry

Good vibrations could revolutionize assisted reproductive technology

[Press-News.org] Community-based treatment of malaria, pneumonia could save lives, BU study finds