NASA-sponsored study describes how space flight impacts astronauts' eyes and vision

(Press-News.org) Minneapolis – November 14, 2011 - North American Neuro-Ophthalmology Society (NANOS) member describes novel eye findings in astronauts after long duration space flight

A newly published ophthalmologic study recently described the history, clinical findings, and possible etiologies of novel ophthalmic findings discovered in astronauts after long-duration space flights. The study team included ophthalmologists Thomas H. Mader, MD, of Alaska Native Medical Center and neuro-ophthalmologist and NANOS member, Andrew G. Lee, MD, Professor and Chair of the Department of Ophthalmology of The Methodist Hospital, Houston, Texas. The report is published in October's Ophthalmology, the journal of the American Academy of Ophthalmology.

The authors reported eye exam findings in seven astronauts as well as an analysis of post-flight questionnaires regarding in-flight vision changes in approximately 300 additional astronauts. The seven astronauts with ocular anomalies had returned from long-duration space missions to the International Space Station (ISS) and all seven subjects had undergone complete eye examinations, including dilated exams and photographs of the back of the eye. Several had MRI scans, spinal taps, and computerized analysis of their optic nerve. After 6 months of space flight, all 7 astronauts had eye findings, including swollen optic nerves, distortion of the shape of the eyeball, and retinal changes. Most became more farsighted, and had blurred vision, especially at near. The spinal taps showed either top normal or slightly elevated pressures in the spinal fluid surrounding the brain and optic nerves.

The 300 post-flight questionnaires documented that approximately 29% and 60% of astronauts on short and long-duration missions, respectively, experienced a worsening of distance or near visual acuity. Some of these vision changes remain unresolved years after flight. The authors theorized that changes may have resulted from fluid shifts brought about by prolonged exposure to low gravity. The findings might represent parts of a spectrum of ocular and brain responses to extended exposure to low gravity. Future research is ongoing for astronauts entering new missions.

### References 1. Mader TH, Gibson CR, Pass AF, Kramer LA, Lee AG, Fogarty J, et al. Optic Disc Edema, Globe Flattening, Choroidal Folds, and Hyperopic Shifts Observed in Astronauts after Long-duration Space Flight. Ophthalmology 118(10):2058-2069 October 2011.

Note to media: Contact NANOS at info@nanosweb.org to request full text of the study and arrange interviews with experts.

About the North American Neuro-Ophthalmology Society The North American Neuro-Ophthalmology Society (NANOS) is the only organization dedicated to the advancement of neuro-ophthalmologic education and information in North America and has over 500 members. NANOS is dedicated to the achievement of excellence in patient care through the support and promotion of education, communication, research, and the practice of neuro-ophthalmology. For more information, please visit www.nanosweb.org.