PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Long-term ICS use reduces pleural effusion in patients with CAP

2012-05-23
(Press-News.org) ATS 2012, SAN FRANCISCO – Prior treatment with inhaled corticosteroids in patients with respiratory disorders who develop community acquired pneumonia (CAP) is associated with a lower incidence and severity of parapneumonic effusion, according to a new study from researchers in Spain. A parapneumonic effusion is a type of pleural effusion (excess fluid that accumulates between the two pleural layers, the fluid-filled space that surrounds the lungs) that arises as a result of a pneumonia, lung abscess, or bronchiectasis. "Long-term treatment with inhaled corticosteroids is associated with an elevated risk of CAP in patients with COPD, while at the same time, use of inhaled corticosteroids is also associated with less CAP severity and a lower risk of pneumonia-related mortality," said Jacobo Sellares, MD, PhD, associate faculty member at Hospital Clínic – The August Pi I Sunyer Biomedical Research Institute (IDIBAPS) in Barcelona, Spain. "In our study, prior treatment with inhaled corticosteroids in patients who developed CAP was associated with a lower incidence and less severity of parapneumonic effusion, regardless of the patient's baseline chronic respiratory condition."

The results will be presented at the ATS 2012 International Conference in San Francisco.

The single center study enrolled 3,602 consecutive patients with a diagnosis of CAP. Of these, 659 (18%) had respiratory disorders treated with inhaled corticosteroids before CAP was diagnosed. Respiratory disorders included COPD (56%), asthma (13%), bronchiectasis (6%), and other disorders (25%).

Patients with prior treatment with inhaled corticosteroids, compared with those without, had a significantly lower incidence of parapneumonic effusion (5% vs. 12%). This association remained significant after adjustment for age, sex, comorbidities, and CAP severity. Prior corticosteroid treatment was associated with a higher incidence of simple parapneumonic effusion and a lower incidence of empyema compared with no prior corticosteroid treatment.

Baseline pulmonary disorder did not affect the relationship between corticosteroid treatment and parapneumonic effusion.

"Pleural infection is common in patients with CAP and is associated with an increased mortality risk," said Dr. Sellares. "Our results show that previous treatment of respiratory disorders with inhaled corticosteroids may reduce the risk of developing this dangerous complication."

The potential preventive role of inhaled corticosteroids in preventing parapneumonic effusion in patients with high risk of CAP must be clarified in future randomized studies, according to Dr. Sellares. ### "Influence Of Long-Term Use Of Inhaled Corticoids On The Development Of Pleural Effusion In Community Acquired Pneumonia" (Session D14, Wednesday, May 23, 8:15-10:45 a.m., Room 2001-2003, Moscone Convention Center; Abstract 30951)

* Please note that numbers in this release may differ slightly from those in the abstract. Many of these investigations are ongoing; the release represents the most up-to-date data available at press time.

Abstract 30951
Influence Of Long-Term Use Of Inhaled Corticoids On The Development Of Pleural Effusion In Community Acquired Pneumonia
Type: Scientific Abstract
Category: 10.03 - Community Acquired Respiratory Infections (Including Epidemiology) (MTPI)
Authors: J. Sellares1, A. Lopez-Guiraldo1, C. Lucena1, E. Polverino1, C. Cilloniz1, R. Amaro1, M.A. Marcos1, J. Mensa1, A. Torres2; 1Hospital Clinic - Barcelona/ES, 2Hospital Clinic Del Barcelona / - Barcelona/ES

Abstract Body Rationale Long-term use of inhaled corticosteroids (ICS) in patients with Chronic Obstructive Pulmonary Disease (COPD) has been associated with increase risk of CAP. By contrast ICS have been associated with less CAP severity and a decreased risk of pneumonia-related mortality. Pleural infection is a frequent complication of CAP that may increase mortality. The objective of this study was to assess the influence of long-term use of ICS on the incidence and severity of parapneumonic effusion in patients with different baseline respiratory disorders. Methods We conducted a single centre cohort study of 3602 patients consecutively collected with the diagnosis of CAP. We assessed clinical, radiographic and pleural fluid chemistry and microbiological variables. Pleural effusion was classified according to American College of Chest Physicians guidelines. Patients were classified whether they received prior ICS treatment or not. Results 659 patients (18%) were treated with ICS before diagnosis of CAP (COPD: 56% Asthma: 13%, Bronchiectasis: 6%, others: 25%). Prior treatment with ICS was significant associated with less incidence of parapneumonic effusion compared to those without prior ICS treatment (5% vs. 12%, p END


ELSE PRESS RELEASES FROM THIS DATE:

Tiny implanted coil improves lung function in patients with severe emphysema

2012-05-23
ATS 2012, SAN FRANCISCO – A tiny, resilient metal wire designed to gather and compress diseased lung tissue may offer relief to patients with severe heterogeneous emphysema, a subtype of the disease that involves specific, usually isolated areas of the lungs, according to the results of a multicenter international trial conducted in the Netherlands, Germany and France. The wire, called a lung volume reduction coil (LVRC), can be easily implanted and is designed to take the place of more invasive procedures used to improve the lung function of emphysema patients. The study ...

Study shows antibiotic improves respiratory function in lung transplant patients

2012-05-23
ATS 2012, SAN FRANCISCO – Researchers in the United Kingdom have determined that azithromycin, a broad-spectrum antibiotic that also has anti-inflammatory properties, can be an effective treatment option for patients suffering from bronchiolitis obliterans syndrome (BOS), a life-threatening complication that occurs in the majority of patients following lung transplantation. BOS is the leading cause of mortality after the first year following transplantation, and occurs in part when the body repeatedly rejects the transplanted lung tissue. The syndrome causes the airways ...

P. aeruginosa bacteria associated with increased hospitalizations in COPD patients

2012-05-23
ATS 2012, SAN FRANCISCO – Patients with chronic obstructive pulmonary disease (COPD) who become infected with the bacterium Pseudomonas aerguinosa are more likely to have worse clinical outcomes and experience more hospitalizations during the course of their disease than COPD patients who are not infected, according to researchers from Buffalo, N.Y. The study will be presented at the ATS 2012 International Conference in San Francisco. Bacterial bronchial infection plays a key role in the course of COPD, causing chronic inflammation as well as acute exacerbations of ...

Mortality rates decrease, chronic disease rates increase among HIV+ ICU patients

2012-05-23
ATS 2012, SAN FRANCISCO – The expanded use of antiretrovirals, potent drugs used to treat retroviral infections such as human immunodeficiency virus (HIV), has been linked to significant decreases in hospital mortality rates among severely ill HIV-positive(HIV+) patients nationwide, primarily due to a decrease in opportunistic infections, according to a new study by researchers at Stanford University. Despite these encouraging data, the study also revealed that in this population, chronic diseases and bloodstream infections are on the rise. The study results will be presented ...

Breast MRI helps predict chemotherapy's effectiveness

2012-05-23
OAK BROOK, Ill. – Magnetic resonance imaging (MRI) provides an indication of a breast tumor's response to pre-surgical chemotherapy significantly earlier than possible through clinical examination, according to a new study published online in the journal Radiology. Women with breast cancer often undergo chemotherapy prior to surgery. Research has shown that women who receive this treatment, known as neoadjuvant chemotherapy, are more likely to achieve breast conservation than those receiving chemotherapy after surgery. Clinicians track a patient's response to neoadjuvant ...

Researchers uncover new ways sleep-wake patterns are like clockwork

2012-05-23
Researchers at New York University and Albert Einstein College of Medicine of Yeshiva University have discovered new ways neurons work together to ease the transition between sleep and wakefulness. Their findings, which appear in the journal Neuron, provide additional insights into sleep-wake patterns and offer methods to explore what may disrupt them. Their study explored the biological, or circadian, clocks of Drosophila fruit flies, which are commonly used for research in this area. This is because it is relatively easy to find mutants with malfunctioning biological ...

Mayo Clinic urologists present findings at American Urological Association Annual Meeting

2012-05-23
ROCHESTER, Minn. -- Mayo Clinic researchers will present findings on prostate cancer risk, screening, treatment and other urological research at the annual meeting of the American Urological Association May 19-23 in Atlanta. Mayo Clinic urologists will also be available to provide expert comment for reporters covering the conference. Mayo Clinic studies that will be presented and their embargo dates include: No negative impact on overall survival from post-prostate surgery hormone therapy Embargoed until 10:30 a.m. ET Monday, May 21 In a first-of-its-kind study ...

Treating pain with transplants

2012-05-23
A new study finds that transplanting embryonic cells into adult mouse spinal cord can alleviate persistent pain. The research, published by Cell Press in the May 24th issue of the journal Neuron, suggests that reduced pain results from successful integration of the embryonic cells into the host spinal cord. The findings open avenues for clinical strategies aimed not just at treating the symptoms of chronic debilitating pain, but correcting the underlying disease pathology. There are two major classes of chronic pain: inflammatory pain that results from injury to tissue, ...

Why cutting sugar can control seizures: Scientists identify metabolic regulator of epilepsy

2012-05-23
A new study unravels a link between a protein that can modify cellular metabolism in the brain and seizure susceptibility. The research, published by Cell Press in the May 24th issue of the journal Neuron, may lead to the development of new treatments for epilepsy. Epilepsy is a disorder characterized by seizures, unpredictable and abnormal bursts of electrical activity in the brain. Some cases of epilepsy are resistant to traditional drug treatments but can be improved by a "ketogenic" diet. This type of diet, which is very low in sugars and high in fat, forces neurons ...

Dollars and sense: Why are some people morally against tax?

2012-05-23
As the U.S. presidential election campaigns heat up, the economic debate is dominated by bailouts, austerity and, inevitably, taxation. Now a new study published in Symbolic Interaction asks why tax is such an important issue to voters and explores the moral ideas which underpin their views. Americans are famously hostile to taxes even though they are not heavily taxed in comparison to Canadians and the British. In their study Dr Jeff Kidder and Dr Isaac Martin, from Northern Illinois University and the University of California-San Diego, explore how middle class feelings ...

LAST 30 PRESS RELEASES:

Scientists glimpse how enzymes “dance” while they work, and why that’s important

California partnership aided COVID-19 response and health equity, report finds

University of Oklahoma secures $19.9 million for revolutionary radar technology

Study finds restoring order to dividing cancer cells may prevent metastasis

High-accuracy tumor detection with label-free microscopy and neural networks

Wayne State research reveals fetuses exposed to Zika virus have long-term immune challenges

Researchers deconstruct chikungunya outbreaks to improve prediction and vaccine development

Study finds one-year change on CT scans linked to future outcomes in fibrotic lung disease

Discovery of a novel intracellular trafficking pathway in plant cells

New tool helps forecast volcano slope collapses and tsunamis

Molecular coating cleans up noisy quantum light

From Parkinson's to rare diseases, discovered a key switch for cellular health

Tiny sugars in the brain disrupt emotional circuits, fueling depression

Mini-organs reveal how the cervix defends itself

Africa, climate, and food: How to feed a continent without increasing its carbon footprint

Researchers demonstrates substrate design principles for scalable superconducting quantum materials

How better software choices could cut US health care costs

Concussion history in NCAA athletes yields mixed health outcomes

Counting plastic reveals hidden waste and sparks action

Warming oceans may pose a serious threat to American lobsters

Deaths from drug-induced unintentional injury rise across the US

In car crashes with pedestrians, age and zip code may predict extent of traumatic injuries

AI optimizes evacuation, diagnosis, and treatment of wounded soldiers in Ukraine

Mastectomy linked to worsened sexual health, body image after surgery

Drop in credit score after cancer diagnosis linked to increased mortality, study shows

Use of weight loss drugs before bariatric surgery has soared in recent years, study finds

EMS call times in rural areas take at least 20 minutes longer than national average

Rectal bleeding in young adults linked to 8.5 times higher risk of colorectal cancer

Hospital closures disproportionately affect socioeconomically disadvantaged communities

Global disparities in premature mortality

[Press-News.org] Long-term ICS use reduces pleural effusion in patients with CAP