(Press-News.org) It's a project 500 million years in the making. Only this time, instead of playing on a movie screen in Jurassic Park, it's happening in a lab at the Georgia Institute of Technology.
Using a process called paleo-experimental evolution, Georgia Tech researchers have resurrected a 500-million-year-old gene from bacteria and inserted it into modern-day Escherichia coli(E. coli) bacteria. This bacterium has now been growing for more than 1,000 generations, giving the scientists a front row seat to observe evolution in action.
"This is as close as we can get to rewinding and replaying the molecular tape of life," said scientist Betül Kaçar, a NASA astrobiology postdoctoral fellow in Georgia Tech's NASA Center for Ribosomal Origins and Evolution. "The ability to observe an ancient gene in a modern organism as it evolves within a modern cell allows us to see whether the evolutionary trajectory once taken will repeat itself or whether a life will adapt following a different path."
In 2008, Kaçar's postdoctoral advisor, Associate Professor of Biology Eric Gaucher, successfully determined the ancient genetic sequence of Elongation Factor-Tu (EF-Tu), an essential protein in E. coli. EFs are one of the most abundant proteins in bacteria, found in all known cellular life and required for bacteria to survive. That vital role made it a perfect protein for the scientists to answer questions about evolution.
After achieving the difficult task of placing the ancient gene in the correct chromosomal order and position in place of the modern gene within E. coli, Kaçar produced eight identical bacterial strains and allowed "ancient life" to re-evolve. This chimeric bacteria composed of both modern and ancient genes survived, but grew about two times slower than its counterpart composed of only modern genes.
"The altered organism wasn't as healthy or fit as its modern-day version, at least initially," said Gaucher, "and this created a perfect scenario that would allow the altered organism to adapt and become more fit as it accumulated mutations with each passing day."
The growth rate eventually increased and, after the first 500 generations, the scientists sequenced the genomes of all eight lineages to determine how the bacteria adapted. Not only did the fitness levels increase to nearly modern-day levels, but also some of the altered lineages actually became healthier than their modern counterpart.
When the researchers looked closer, they noticed that every EF-Tu gene did not accumulate mutations. Instead, the modern proteins that interact with the ancient EF-Tu inside of the bacteria had mutated and these mutations were responsible for the rapid adaptation that increased the bacteria's fitness. In short, the ancient gene has not yet mutated to become more similar to its modern form, but rather, the bacteria found a new evolutionary trajectory to adapt.
These results were presented at the recent NASA International Astrobiology Science Conference. The scientists will continue to study new generations, waiting to see if the protein will follow its historical path or whether it will adopt via a novel path altogether.
"We think that this process will allow us to address several longstanding questions in evolutionary and molecular biology," said Kaçar. "Among them, we want to know if an organism's history limits its future and if evolution always leads to a single, defined point or whether evolution has multiple solutions to a given problem."
INFORMATION:
Giving ancient life another chance to evolve
Scientists place 500-million-year-old gene in modern organism
2012-07-12
ELSE PRESS RELEASES FROM THIS DATE:
How metastasizing cancer cells enter organs
2012-07-12
This press release is available in German.
It is not primary tumors that are responsible for the majority of cancer deaths, but rather their metastases. Physiologists and neuropathologists from the University of Zurich have now identified the origin of metastasis formation, thereby becoming the first to reveal the pathway of metastasizing intestinal cancer cells out of the blood stream. The results allow new approaches in the development of cancer therapies.
Every year, over seven million people die of cancer worldwide. Thanks to more effective therapy and better ...
Identifying risky behaviors: The key to HIV prevention
2012-07-12
HIV prevention must be better targeted, according to David Holtgrave from Johns Hopkins Bloomberg School of Public Health in the US, and colleagues. Health care professionals need a more detailed analysis and understanding of the interplay between HIV risk behavior, access to treatment and treatment success among those living with HIV. The authors discuss their proposed framework in a study¹ in a special issue of Springer's journal AIDS and Behavior. The special issue, "Turning the Tide Together: Advances in Behavioral Interventions Research"² is freely available online ...
The more gray matter you have, the more altruistic you are
2012-07-12
This press release is available in German.
The volume of a small brain region influences one's predisposition for altruistic behavior. Researchers from the University of Zurich show that people who behave more altruistically than others have more gray matter at the junction between the parietal and temporal lobe, thus showing for the first time that there is a connection between brain anatomy, brain activity and altruistic behavior.
Why are some people very selfish and others very altruistic? Previous studies indicated that social categories like gender, income ...
Air in expectant moms' homes contains pesticides, border study finds
2012-07-12
HARLINGEN, Texas (July 11, 2012) — Air samples from homes of Hispanic mothers-to-be along the Texas-Mexico border contained multiple pesticides in a majority of the houses, according to a study conducted by the School of Medicine at The University of Texas Health Science Center San Antonio.
All the women were in the third trimester of pregnancy, when the fetal brain undergoes a growth spurt. Several studies have reported that pesticide exposure may adversely affect mental and motor development during infancy and childhood. The new report is in the summer issue of the ...
Down on the cacao farm: Sloths thrive at chocolate's source
2012-07-12
MADISON -- Like many Neotropical fauna, sloths are running out of room to maneuver.
As forests in South and Central America are cleared for agriculture and other human uses, populations of these arboreal leaf eaters, which depend on large trees for both food and refuge, can become isolated and at risk. But one type of sustainable agriculture, shade grown cacao plantations, a source of chocolate, could become critical refuges and bridges between intact forests for the iconic animals.
In an ongoing study in Costa Rica, wildlife biologists from the University of Wisconsin-Madison ...
Middle-aged women who were child abuse victims at increased risk for heart disease, diabetes
2012-07-12
WASHINGTON – Middle-aged women who report having been physically abused as children are about two times more likely than other women their age to have high blood pressure, high blood sugar, a larger waistline and poor cholesterol levels, according to a new study published by the American Psychological Association.
These women are diagnosed as having metabolic syndrome which, according to previous research, places them at an increased risk of developing heart disease and Type 2 diabetes. This link between physical abuse and metabolic syndrome persisted beyond traditional ...
Summer Olympics go for the green as London prepares to host the world
2012-07-12
New Rochelle, NY, July 11, 2012—As athletes from around the world compete for medals at the Summer Olympics in London, the city will be striving to meet Olympic-level sustainability goals. A fascinating first-person view of how these sustainability targets were developed and will be achieved is featured in Sustainability: The Journal of Record, a publication of Mary Ann Liebert, Inc., publishers (www.liebertpub.com) The article is available free online at the Sustainability: The Journal of Record (www.liebertpub.com/sus) website.
The central location of the Summer 2012 ...
Cochrane finds no reliable evidence on effectiveness of electric fans in heatwaves
2012-07-12
A new Cochrane systematic review of the effects of electric fans in heatwaves has found no high quality evidence to guide future national and international policies. The review outlines the type of study that would help resolve the uncertainty which is spelt out in a podcast and an editorial all published today in The Cochrane Library.
Heatwaves in Europe and the USA have led to increasing interest in health protection measures to reduce the impacts of such extreme weather events on human health. Heatwaves are also an issue for mass gatherings and heatwave planning has ...
ONR opens a gateway to improved network data sharing on Navy ships
2012-07-12
ARLINGTON, Va.—An Office of Naval Research (ONR) universal gateway that gives Sailors access to more accurate, secure, real-time information will be delivered to the fleet in just three years from the project's inception at ONR officials announced July 11.
On any Navy destroyer, cruiser or carrier today, there are two networks: one for combat systems (weapons and sensors) and one for command and control, or C2, which also encompasses intelligence, surveillance and reconnaissance. There are some 30 interconnections between the two networks, making it difficult to integrate ...
Got milk? Climate change means stressed cows in southern US may have less
2012-07-12
"Cows are happy in parts of Northern California and not in Florida" is a good way to sum up the findings of new research from the University of Washington, said Yoram Bauman, best known as the "stand-up economist."
Bauman and colleagues found that the decline in milk production due to climate change will vary across the U.S., since there are significant differences in humidity and how much the temperature swings between night and day across the country. For instance, the humidity and hot nights make the Southeast the most unfriendly place in the country for dairy cows.
Their ...
LAST 30 PRESS RELEASES:
Thirty-year mystery of dissonance in the “ringing” of black holes explained
Less intensive works best for agricultural soil
Arctic rivers project receives “national champion” designation from frontiers foundation
Computational biology paves the way for new ALS tests
Study offers new hope for babies born with opioid withdrawal syndrome
UT, Volkswagen Group of America celebrate research partnership
New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll
Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes
University of Cincinnati Cancer Center presents research at AACR 2025
Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025
AACR: Researchers share promising results from MD Anderson clinical trials
New research explains why our waistlines expand in middle age
Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker
Chips off the old block
Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia
Cutting the complexity from digital carpentry
Lung immune cell type “quietly” controls inflammation in COVID-19
Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity
State and sociodemographic trends in US cigarette smoking with future projections
Young adults drive historic decline in smoking
NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research
Chimpanzee stem cells offer new insights into early embryonic development
This injected protein-like polymer helps tissues heal after a heart attack
FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology
In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity
Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects
A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions
AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate
Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative
Structure dictates effectiveness, safety in nanomedicine
[Press-News.org] Giving ancient life another chance to evolveScientists place 500-million-year-old gene in modern organism