PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Giving ancient life another chance to evolve

Scientists place 500-million-year-old gene in modern organism

2012-07-12
(Press-News.org) It's a project 500 million years in the making. Only this time, instead of playing on a movie screen in Jurassic Park, it's happening in a lab at the Georgia Institute of Technology.

Using a process called paleo-experimental evolution, Georgia Tech researchers have resurrected a 500-million-year-old gene from bacteria and inserted it into modern-day Escherichia coli(E. coli) bacteria. This bacterium has now been growing for more than 1,000 generations, giving the scientists a front row seat to observe evolution in action.

"This is as close as we can get to rewinding and replaying the molecular tape of life," said scientist Betül Kaçar, a NASA astrobiology postdoctoral fellow in Georgia Tech's NASA Center for Ribosomal Origins and Evolution. "The ability to observe an ancient gene in a modern organism as it evolves within a modern cell allows us to see whether the evolutionary trajectory once taken will repeat itself or whether a life will adapt following a different path."

In 2008, Kaçar's postdoctoral advisor, Associate Professor of Biology Eric Gaucher, successfully determined the ancient genetic sequence of Elongation Factor-Tu (EF-Tu), an essential protein in E. coli. EFs are one of the most abundant proteins in bacteria, found in all known cellular life and required for bacteria to survive. That vital role made it a perfect protein for the scientists to answer questions about evolution.

After achieving the difficult task of placing the ancient gene in the correct chromosomal order and position in place of the modern gene within E. coli, Kaçar produced eight identical bacterial strains and allowed "ancient life" to re-evolve. This chimeric bacteria composed of both modern and ancient genes survived, but grew about two times slower than its counterpart composed of only modern genes.

"The altered organism wasn't as healthy or fit as its modern-day version, at least initially," said Gaucher, "and this created a perfect scenario that would allow the altered organism to adapt and become more fit as it accumulated mutations with each passing day."

The growth rate eventually increased and, after the first 500 generations, the scientists sequenced the genomes of all eight lineages to determine how the bacteria adapted. Not only did the fitness levels increase to nearly modern-day levels, but also some of the altered lineages actually became healthier than their modern counterpart.

When the researchers looked closer, they noticed that every EF-Tu gene did not accumulate mutations. Instead, the modern proteins that interact with the ancient EF-Tu inside of the bacteria had mutated and these mutations were responsible for the rapid adaptation that increased the bacteria's fitness. In short, the ancient gene has not yet mutated to become more similar to its modern form, but rather, the bacteria found a new evolutionary trajectory to adapt.

These results were presented at the recent NASA International Astrobiology Science Conference. The scientists will continue to study new generations, waiting to see if the protein will follow its historical path or whether it will adopt via a novel path altogether.

"We think that this process will allow us to address several longstanding questions in evolutionary and molecular biology," said Kaçar. "Among them, we want to know if an organism's history limits its future and if evolution always leads to a single, defined point or whether evolution has multiple solutions to a given problem."

INFORMATION:


ELSE PRESS RELEASES FROM THIS DATE:

How metastasizing cancer cells enter organs

2012-07-12
This press release is available in German. It is not primary tumors that are responsible for the majority of cancer deaths, but rather their metastases. Physiologists and neuropathologists from the University of Zurich have now identified the origin of metastasis formation, thereby becoming the first to reveal the pathway of metastasizing intestinal cancer cells out of the blood stream. The results allow new approaches in the development of cancer therapies. Every year, over seven million people die of cancer worldwide. Thanks to more effective therapy and better ...

Identifying risky behaviors: The key to HIV prevention

2012-07-12
HIV prevention must be better targeted, according to David Holtgrave from Johns Hopkins Bloomberg School of Public Health in the US, and colleagues. Health care professionals need a more detailed analysis and understanding of the interplay between HIV risk behavior, access to treatment and treatment success among those living with HIV. The authors discuss their proposed framework in a study¹ in a special issue of Springer's journal AIDS and Behavior. The special issue, "Turning the Tide Together: Advances in Behavioral Interventions Research"² is freely available online ...

The more gray matter you have, the more altruistic you are

2012-07-12
This press release is available in German. The volume of a small brain region influences one's predisposition for altruistic behavior. Researchers from the University of Zurich show that people who behave more altruistically than others have more gray matter at the junction between the parietal and temporal lobe, thus showing for the first time that there is a connection between brain anatomy, brain activity and altruistic behavior. Why are some people very selfish and others very altruistic? Previous studies indicated that social categories like gender, income ...

Air in expectant moms' homes contains pesticides, border study finds

2012-07-12
HARLINGEN, Texas (July 11, 2012) — Air samples from homes of Hispanic mothers-to-be along the Texas-Mexico border contained multiple pesticides in a majority of the houses, according to a study conducted by the School of Medicine at The University of Texas Health Science Center San Antonio. All the women were in the third trimester of pregnancy, when the fetal brain undergoes a growth spurt. Several studies have reported that pesticide exposure may adversely affect mental and motor development during infancy and childhood. The new report is in the summer issue of the ...

Down on the cacao farm: Sloths thrive at chocolate's source

2012-07-12
MADISON -- Like many Neotropical fauna, sloths are running out of room to maneuver. As forests in South and Central America are cleared for agriculture and other human uses, populations of these arboreal leaf eaters, which depend on large trees for both food and refuge, can become isolated and at risk. But one type of sustainable agriculture, shade grown cacao plantations, a source of chocolate, could become critical refuges and bridges between intact forests for the iconic animals. In an ongoing study in Costa Rica, wildlife biologists from the University of Wisconsin-Madison ...

Middle-aged women who were child abuse victims at increased risk for heart disease, diabetes

2012-07-12
WASHINGTON – Middle-aged women who report having been physically abused as children are about two times more likely than other women their age to have high blood pressure, high blood sugar, a larger waistline and poor cholesterol levels, according to a new study published by the American Psychological Association. These women are diagnosed as having metabolic syndrome which, according to previous research, places them at an increased risk of developing heart disease and Type 2 diabetes. This link between physical abuse and metabolic syndrome persisted beyond traditional ...

Summer Olympics go for the green as London prepares to host the world

2012-07-12
New Rochelle, NY, July 11, 2012—As athletes from around the world compete for medals at the Summer Olympics in London, the city will be striving to meet Olympic-level sustainability goals. A fascinating first-person view of how these sustainability targets were developed and will be achieved is featured in Sustainability: The Journal of Record, a publication of Mary Ann Liebert, Inc., publishers (www.liebertpub.com) The article is available free online at the Sustainability: The Journal of Record (www.liebertpub.com/sus) website. The central location of the Summer 2012 ...

Cochrane finds no reliable evidence on effectiveness of electric fans in heatwaves

2012-07-12
A new Cochrane systematic review of the effects of electric fans in heatwaves has found no high quality evidence to guide future national and international policies. The review outlines the type of study that would help resolve the uncertainty which is spelt out in a podcast and an editorial all published today in The Cochrane Library. Heatwaves in Europe and the USA have led to increasing interest in health protection measures to reduce the impacts of such extreme weather events on human health. Heatwaves are also an issue for mass gatherings and heatwave planning has ...

ONR opens a gateway to improved network data sharing on Navy ships

2012-07-12
ARLINGTON, Va.—An Office of Naval Research (ONR) universal gateway that gives Sailors access to more accurate, secure, real-time information will be delivered to the fleet in just three years from the project's inception at ONR officials announced July 11. On any Navy destroyer, cruiser or carrier today, there are two networks: one for combat systems (weapons and sensors) and one for command and control, or C2, which also encompasses intelligence, surveillance and reconnaissance. There are some 30 interconnections between the two networks, making it difficult to integrate ...

Got milk? Climate change means stressed cows in southern US may have less

2012-07-12
"Cows are happy in parts of Northern California and not in Florida" is a good way to sum up the findings of new research from the University of Washington, said Yoram Bauman, best known as the "stand-up economist." Bauman and colleagues found that the decline in milk production due to climate change will vary across the U.S., since there are significant differences in humidity and how much the temperature swings between night and day across the country. For instance, the humidity and hot nights make the Southeast the most unfriendly place in the country for dairy cows. Their ...

LAST 30 PRESS RELEASES:

Exercise as an anti-ageing intervention to avoid detrimental impact of mental fatigue

UMass Amherst Nursing Professor Emerita honored as ‘Living Legend’

New guidelines aim to improve cystic fibrosis screening

Picky eaters by day, buffet by night: Butterfly, moth diets sync to plant aromas

Pennington Biomedical’s Dr. Leanne Redman honored with the E. V. McCollum Award from the American Society for Nutrition

CCNY physicists uncover electronic interactions mediated via spin waves

Researchers’ 3D-printing formula may transform future of foam

Nurture more important than nature for robotic hand

Drug-delivering aptamers target leukemia stem cells for one-two knockout punch

New study finds that over 95% of sponsored influencer posts on Twitter were not disclosed

New sea grant report helps great lakes fish farmers navigate aquaculture regulations

Strain “trick” improves perovskite solar cells’ efficiency

How GPS helps older drivers stay on the roads

Estrogen and progesterone stimulate the body to make opioids

Dancing with the cells – how acoustically levitating a diamond led to a breakthrough in biotech automation

Machine learning helps construct an evolutionary timeline of bacteria

Cellular regulator of mRNA vaccine revealed... offering new therapeutic options

Animal behavioral diversity at risk in the face of declining biodiversity

Finding their way: GPS ignites independence in older adult drivers

Antibiotic resistance among key bacterial species plateaus over time

‘Some insects are declining but what’s happening to the other 99%?’

Powerful new software platform could reshape biomedical research by making data analysis more accessible

Revealing capillaries and cells in living organs with ultrasound

American College of Physicians awards $260,000 in grants to address equity challenges in obesity care

Researchers from MARE ULisboa discover that the European catfish, an invasive species in Portugal, has a prolonged breeding season, enhancing its invasive potential

Rakesh K. Jain, PhD, FAACR, honored with the 2025 AACR Award for Lifetime Achievement in Cancer Research

Solar cells made of moon dust could power future space exploration

Deporting immigrants may further shrink the health care workforce

Border region emergency medical services in migrant emergency care

Resident physician intentions regarding unionization

[Press-News.org] Giving ancient life another chance to evolve
Scientists place 500-million-year-old gene in modern organism