(Press-News.org) CHICAGO – Treatment with growth hormone-releasing hormone appears to be associated with favorable cognitive effects among both adults with mild cognitive impairment and healthy older adults, according to a randomized clinical trial published Online First by Archives of Neurology, a JAMA Network publication.
"Growth hormone-releasing hormone (GHRH), growth hormone and insulinlike growth factor 1 have potent effects on brain function, their levels decrease with advancing age, and they likely play a role in the pathogenesis of Alzheimer disease," the authors write as background information in the study.
To examine the effects of GHRH on cognitive function in healthy older adults and in adults with mild cognitive impairment (MCI), Laura D. Baker, Ph.D., of the University of Washington School of Medicine and Veterans Affairs Puget Sound Health Care System, Seattle, and colleagues, conducted a randomized, double-blind, placebo-controlled trial in which participants self-administered daily injections of a form of human GHRH (tesamorelin), or placebo.
The authors enrolled 152 adults ranging in age from 55 to 87 years (average age, 68 years) and 137 participants (76 healthy patients and 61 patients with MCI) successfully completed the study. At baseline, at 10 and 20 weeks of treatment, and after a 10-week washout (30 weeks total), the authors collected blood samples and administered parallel versions of cognitive tests.
Among the original 152 patients enrolled in the study, analysis indicated a favorable effect of GHRH on cognition, which was comparable in adults with MCI and healthy older adults. Analysis among the 137 patients who successfully completed the trial also showed that treatment with GHRH had a favorable effect on cognition among both groups of patients. Although the healthy adults outperformed those with MCI overall, the cognitive benefits relative to placebo was comparable among both groups.
Treatment with GHRH also increased insulinlike growth factor 1 levels by 117 percent, which remained within the physiological range, and increased fasting insulin levels within the normal range by 35 percent in adults with MCI but not in healthy adults.
"Our results replicate and expand our earlier positive findings, demonstrating that GHRH administration has favorable effects on cognitive function not only in healthy older adults but also in adults at increased risk of cognitive decline and dementia," the authors conclude. "Larger and longer-duration treatment trials are needed to firmly establish the therapeutic potential of GHRH administration to promote brain health in normal aging and 'pathological aging.'"
INFORMATION: (Arch Neurol. Published online August 6, 2012. doi:10.1001/archneurol.2012.1970. Available pre-embargo to the media at http://media.jamanetwork.com.)
Editor's Note: Tesamorelin and placebo were provided at no cost to the study by Theratechnologies, Inc. This research was supported by National Institutes of Health/National Institute of Aging grants, and by the U.S. Department of Veterans Affairs. A portion of the work was conduced through the Clinical Research Center Facility at the University of Washington Medical Center, which is supported by a National Institutes of Health/National Center for Research Resources grant. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
To contact Laura D. Baker, Ph.D., call Leila Gray at 206-685-0381 or email leilag@uw.edu.
CHICAGO – Patients with hoarding disorder exhibited abnormal activity in regions of the brain that was stimulus dependent when deciding what to do with objects that did or did not belong to them, according to a report in the August issue of Archives of General Psychiatry, a JAMA Network publication.
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David F. Tolin, Ph.D., of the Institute of Living, Hartford, ...
White children are more likely to receive cranial (head) CT scans in an emergency department following minor head trauma, compared with African-American or Hispanic children, a study published by researchers at UC Davis has found.
The study findings do not indicate that CT (computed tomography) scans are underused in African-American and Hispanic children. Rather, the researchers suggested that white children may receive too many CT scans and thus may be exposed to unnecessary radiation.
The results are online and appear in the August issue of the Archives of Pediatrics ...
Just as differences in song can be used to distinguish one bird species from another, the pips and squeaks bats use to find prey can be used to identify different species of bat. Now, for the first time, ecologists have developed a Europe-wide tool capable of identifying bats from their echolocation calls.
The new free online tool – iBatsID – will be a major boost to conserving bats, whose numbers have declined significantly across Europe over the past 50 years. Details are published today in the British Ecological Society's Journal of Applied Ecology.
Working with ...
LEXINGTON, Ky. (Aug. 6 , 2012) — University of Kentucky researchers, led by Dr. Jayakrishna Ambati, have made an exciting finding in the "dry" form of age-related macular degeneration known as geographic atrophy (GA). GA is an untreatable condition that causes blindness in millions of individuals due to death of retinal pigmented epithelial cells. The paper, "ERK1/2 Activation is a Therapeutic Target in Age-Related Macular Degeneration" appears in the current online issue of the premier journal Proceedings of the National Academy of Sciences.
Ambati, professor of physiology, ...
Despite advances in health care and increases in life expectancy overall, Americans with less than a high school education have life expectancies similar to adults in the 1950s and 1960s.
"The most highly educated white men live about 14 years longer than the least educated black men," says S. Jay Olshansky, professor of epidemiology at the University of Illinois at Chicago School of Public Health and lead author of the study. "The least educated black women live about 10 years less than the most educated white women."
The research, funded by The MacArthur Foundation ...
An international study, led by researchers at the Medical Research Council Lifecourse Epidemiology Unit (MRC LEU) at the University of Southampton, has found that obese patients who undergo bariatric surgery are not at an increased risk of broken bones in the first few years after the operation.
However, the study, published in the British Medical Journal today (DATE) has shown that there is a possibility of an increase in fracture risk after three to five years.
Generally, a higher Body Mass Index (BMI) protects the bone against most types of fracture because a higher ...
A Yale study of the care quality received at safety-net hospitals — which provide care for the majority of uninsured and other vulnerable populations — found that quality at these facilities is similar to non-safety-net hospitals. This is despite the unique financial challenges at safety-net hospitals in the face of rising costs and the potential impact of the health care law.
Published in the August issue of Health Affairs, the study was conducted by Elizabeth E. Drye, M.D., of the Yale Center for Outcomes Research and Evaluation, Joseph S. Ross, M.D., assistant professor ...
OAKLAND, Calif., August 6, 2012 – Long-term use of commonly used blood pressure medications that increase sensitivity to sunlight is associated with an increased risk of lip cancer in non-Hispanic whites, according to a Kaiser Permanente study that appears in the current online issue of Archives of Internal Medicine.
Funded by the National Cancer Institute, the study found that photosensitizing antihypertensive drugs such as nifedipine and hydrochlorothiazide were associated with cancer of the epithelial cells known as squamous cells—which are the main part of the outermost ...
Implantable cardioverter defibrillators account for one-third of the decrease in cardiac arrests caused by ventricular fibrillation in North-Holland, according to research in Circulation, an American Heart Association journal.
VF is an abnormal heart rhythm that makes the heart quiver so it can't pump blood.
ICDs are small electronic devices implanted in the chest that detect potentially fatal abnormal heart rhythms and try to stop them with electric shocks. Generally, only people with a high risk of sudden cardiac death — mostly those at high risk of abnormal heartbeats ...
Hospitals in areas with large minority populations are more likely to be overcrowded and to divert ambulances, delaying timely emergency care, according to a multi-institutional study focused on California.
The researchers examined ambulance diversion in more than 200 hospitals around the state to assess whether overcrowding in emergency rooms disproportionately affects racial and ethnic minorities. They found that minorities are more at risk of being impacted by ER crowding and by diversion than non-minorities.
The study will be published in the August issue of Health ...
