(Press-News.org) PROVIDENCE, R.I. – A Rhode Island Hospital researcher has found that the use of electronic prescription drug monitoring programs (PMPs) may have a significant impact on the demand for drug treatment programs and how prescribers detect and respond to abuse of painkillers. The study by Traci C. Green, Ph.D., MSc, research scientist in Rhode Island Hospital's department of general internal medicine, is published online in advance of print in the journal Pain Medicine.
The study surveyed 1,385 providers in Rhode Island and Connecticut on their use of state PMPs, and found that PMP use was greater in Connecticut where an electronic PMP is available. PMPs are used to gather information about a patient's prescription history, and have the ability to verify patients' self-reported prescription history of abusable medications, aid in the determination of filling multiple prescriptions of the same drug from multiple providers, and assist in the cataloging of medications that may suggest contra-indications or increased risk of adverse events, like overdose.
Both states have reported significant increases in opioid-related death; in fact, overdose has surpassed motor vehicle crashes as the leading cause of unintentional injury death. A national survey indicates that Rhode Island has the highest per capita illicit drug use and ranks third, behind Oklahoma and Oregon, for non-medical use of prescription opioids among persons age 12 or older.
"Prescription drug monitoring programs have historically been oriented to criminal and judicial end users," Green said. "Use of PMPs by prescribers is growing, but how clinicians in actual practice use the data that these systems contain is not well understood."
The researchers surveyed providers in both states who are licensed to prescribe Schedule II medications. These medications have a high potential for abuse, which may lead to severe psychological or physical dependence. Schedule II medications include morphine, Dilaudid, Demerol, oxycodone, fentanyl, and methamphetamine, among others.
The study found that prescribers' use of an electronic PMPs may influence medical care and decisions, especially with opioid abuse detection, and is associated with clinical responses to suspected doctor shopping or diversion. Doctor shopping refers to patients who seek to obtain multiple prescriptions for abusable medications from multiple doctors.
When prescribers suspected a patient of doctor shopping or diverting medications, PMP users were more likely to ramp up clinical monitoring with urine drug screens or refer the patient to drug treatment. PMP users were also less likely to ignore the warning signs or to call law enforcement.
"One thing is clear," Green said, "Clinicians, not law enforcement, have the medical and behavioral health care expertise to guide patients struggling with addiction to get the help they need, when they are ready for it. PMPs can be an important clinical tool to address possible addiction issues and start that conversation."
Green added, "Our study suggests that if states want wider use of PMPs by their prescribers, we need to increase access to drug treatment, especially opioid-dependence treatment options, if we are going to make headway on the epidemic of painkiller abuse and overdose death in our communities."
Since the mid 1990s, there has been a significant nationwide increase in fatal overdose and opioid-related emergency department visits and hospitalizations, driven by a substantial growth in opioid analgesic prescriptions and non-medical use of prescription opioids. Most states report that just 25 percent of their prescribers are using PMPs, and few states require prescribers to check PMPs before dispensing medication.
"PMPs raise the red flags we could be missing on our own," Green said. "They call attention to multiple prescriptions by different doctors, and note contra-indications that put the patient at risk for injury or death. But not enough prescribers are using them. We need to further educate clinicians about these programs, improve drug treatment options and access, and make electronic PMPs more readily available so that this tool can be used most effectively to prevent unnecessary medication-related injury and death."
###
The study was supported by a research grant from the Centers for Disease Control and Prevention. Green's principal affiliation is Rhode Island Hospital, a member hospital of the Lifespan health system in Rhode Island. She also has an academic appointment at The Warren Alpert Medical School of Brown University. The research is fully supported by Rhode Island Hospital and the Lifespan health system. Other Lifespan researchers involved in the study are Peter D. Friedmann, M.D.; Marita Mann; Sarah Bowman; Nickolas Zaller, Ph.D.; as well as Xaviel Soto and John Gadea of the Connecticut Department of Consumer Protection; and Catherine Cordy and Patrick Kelly of the Board of Pharmacy at the Rhode Island Department of Health.
About Rhode Island Hospital
Founded in 1863, Rhode Island Hospital in Providence, R.I., is a private, not-for-profit hospital and is the principal teaching hospital of The Warren Alpert Medical School of Brown University. A major trauma center for southeastern New England, the hospital is dedicated to being on the cutting edge of medicine and research. Last year, Rhode Island Hospital received more than $55 million in external research funding. It is also home to Hasbro Children's Hospital, the state's only facility dedicated to pediatric care. For more information on Rhode Island Hospital, visit www.rhodeislandhospital.org, follow us on Twitter @RIHospital or like us on Facebook www.facebook.com/rhodeislandhospitalpage.
END
Results of a phase III clinical trial of the drug Enzalutamide, published yesterday in the New England Journal of Medicine, show the drug extends life by an average five months in the most advanced stages of prostate cancer.
"This is a major advance. Not only do we see more survival benefit than from traditional chemotherapy, but the side effects of Enzalutamide are much lower. It provides both more benefit and less harm – you get the quantification of more life, but also see quality of life improvements," says study co-author, Thomas Flaig, MD, medical director of the ...
Quantum computers promise to reach computation speeds far beyond that of today's computers. As they would use quantum effects, however, they would also be susceptible to external interferences. Information flow into and out of the system is a critical point. Researchers from KIT with partners from Grenoble and Strasbourg have now read out the quantum state of an atom directly by using electrodes. In the Nature journal, it is reported about the stable interface between classical and quantum world. (DOI: 10.1038/nature11341)
"Normally, every contact with the outer world ...
Chapel Hill, NC – Leukemia and lymphoma patients who receive life-saving stem cell or bone marrow transplants often experience chronic side effects that significantly decrease quality of life, can last a lifetime, and ultimately affect their long-term survival.
In chronic Graft vs. Host Disease (GVHD), the differences between the donor bone marrow cells and the recipient's body often cause these immune cells to recognize the recipient's body tissues as foreign and the newly transplanted cells attack the transplant recipient's body. Symptoms can range from dry eyes and ...
While your DNA is unique, it also tells the tale of your family line. It carries the genetic history of your ancestors down through the generations. Now, says a Tel Aviv University researcher, it's also possible to use it as a map to your family's past.
Prof. Eran Halperin of TAU's Blavatnik School of Computer Science and Department of Molecular Microbiology and Biotechnology, along with a group of researchers from University of California, Los Angeles, are giving new meaning to the term "genetic mapping." Using a probabilistic model of genetic traits for every coordinate ...
CHAMPAIGN, Ill. — Birds of a feather flock together and – according to a new analysis – so do their lice.
A study of the genetic heritage of avian feather lice indicates that their louse ancestors first colonized a particular group of birds (ducks or songbirds, for example) and then "radiated" to different habitats on those birds – to the wings or heads, for instance, where they evolved into different species. This finding surprised the researchers because wing lice from many types of birds look more similar to one another than they do to head or body lice living on the ...
New Rochelle, NY, August 16, 2012—Every year tribal gaming generates billions of dollars in revenue, creates tens of thousands of jobs, and boosts the economies of many Native American communities. In the state of California alone, tribal gaming has brought in $7.5 billion annually. However, because of the aggressive movement to legalize Internet gambling, which effectively would give states the power to regulate and tax online gambling even on reservations, the financial success of these communities could change. In "Native American Off-Reservation Gaming," an expert roundtable ...
After a surgeon stitches up a patient's abdomen, costly complications -- some life-threatening -- can occur. To cut down on these postoperative problems, Johns Hopkins undergraduates have invented a disposable suturing tool to guide the placement of stitches and guard against the accidental puncture of internal organs.
The student inventors have described their device, called FastStitch, as a cross between a pliers and a hole-puncher. Although the device is still in the prototype stage, the FastStitch team has already received recognition and raised more than $80,000 ...
Ancient pollen and charcoal preserved in deeply buried sediments in Egypt's Nile Delta document the region's ancient droughts and fires, including a huge drought 4,200 years ago associated with the demise of Egypt's Old Kingdom, the era known as the pyramid-building time.
"Humans have a long history of having to deal with climate change," said Christopher Bernhardt, a researcher with the U.S. Geological Survey. "Along with other research, this study geologically reveals that the evolution of societies is sometimes tied to climate variability at all scales – whether decadal ...
Lounging on a sofa while watching a 3D movie is an exquisite pleasure for many film fans. Be that as it may, those nettlesome 3D glasses might diminish the fun somewhat. That's why television manufacturers are working on displays that can recreate the spellbinding magic of three-dimensional television images – without the glasses. Though prototypes of these TV screens already exist, consumers will not have to wait much longer for the market introduction of these autostereoscopic displays. Neverthe-less, the content might be a bit problematic: The 3D movies currently available ...
Fairfax, Va.--The popular spice turmeric packs more than just flavor — it shows promise in fighting devastating viruses, Mason researchers recently discovered.
Curcumin, found in turmeric, stopped the potentially deadly Rift Valley Fever virus from multiplying in infected cells, says Aarthi Narayanan, lead investigator on the new study and a research assistant professor with Mason's National Center for Biodefense and Infectious Diseases.
Mosquito-borne Rift Valley Fever virus (RVF) is an acute, fever-causing virus that affects domestic animals such as cattle, sheep ...