(Press-News.org) Saranac Lake, N.Y. – August 28, 2012 — New research from the laboratory of Dr. Andrea Cooper at the Trudeau Institute, just published in the European Journal of Immunology, holds promise for the improved prevention and treatment of bacterial infections and the life-threatening complications of chronic inflammation that can result from them. The publication title is "Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection".
Following a typical bacterial infection, the immune response is manifested by the accumulation of immune cells within the affected organs. In a bacterial skin infection, for example, this accumulation results in swelling and redness. When infection occurs in internal organs, a similar type of response takes place, but in this setting the immune response can actually damage the organs, resulting in their diminished function. Because of this risk, whenever the immune response acts to control bacteria, the response itself must also be regulated to prevent patient injury.
The publication defines the role of a specific component of the immune response in controlling the extent of the immune response. The authors show that cells that promote damaging inflammation are specifically regulated by the activated immune cells that are part of the inflammatory process. In this way, the immune response undergoes a negative feedback loop that regulates tissue damage but can also limit the expression of bacterial control.
Once bacteria enter the body, the disease process can occur in one of two ways: either the bacteria manipulates the immune regulatory pathways, limiting expression of an immune response (leading to too many bacteria and resulting in tissue damage), or the immune response is not well regulated, and the subsequent inflammatory response damages organs. Maintaining the balance between the killing of bacteria and regulation of the immune response is critical to the health of the patient. The better our understanding of how this balance is generated, the more easily the immune response can be manipulated to achieve an optimal outcome every time it is induced.
INFORMATION:
About the Trudeau Institute
The Trudeau Institute is a nonprofit biomedical research center founded in 1884 by Dr. E.L. Trudeau. The Institute's fundamental research on immunity fosters the development of vaccines, treatments and cures for many life-threatening diseases, including cancer, tuberculosis and influenza. The Institute is supported by federal and state grants and contributions from individuals, private foundations and corporations. For further information about the Trudeau Institute, go to www.trudeauinstitute.org.
Trudeau researchers identify unforeseen regulation of the anti-bacterial immune response
2012-08-28
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
NASA watching Issac's approach to US Gulf Coast
2012-08-28
VIDEO:
An animation of satellite observations from August 26-28, 2012 shows Tropical Storm Isaac moving past the Florida Keys and into the Gulf of Mexico, nearing landfall in the U.S. Gulf...
Click here for more information.
NASA satellites have been providing valuable data to forecasters at the National Hurricane Center watching the development and progression of powerful Tropical Storm Isaac as it heads for landfall.
The Moderate Resolution Imaging Spectroradiometer ...
By detecting smallest virus, researchers open possibilities for early disease detection
2012-08-28
NEW YORK, August 28, 2012 – Researchers at Polytechnic Institute of New York University (NYU-Poly) have created an ultra-sensitive biosensor capable of identifying the smallest single virus particles in solution, an advance that may revolutionize early disease detection in a point-of-care setting and shrink test result wait times from weeks to minutes.
Stephen Arnold, university professor of applied physics and member of the Othmer-Jacobs Department of Chemical and Biomolecular Engineering, and researchers of NYU-Poly's MicroParticle PhotoPhysics Laboratory for BioPhotonics ...
Chinese credit card usage growing quickly, MU study finds
2012-08-28
COLUMBIA, Mo. — In the past two decades, the Chinese economy has undergone many drastic reforms in an effort to compete more effectively on the international market. These reforms included allowing foreign banks to offer credit cards to Chinese citizens. Now, researchers at the University of Missouri have found about 30 percent of Chinese urban households now own at least one credit card and the growth rate of credit card adoption has been an average of 40 percent per year between 2004 and 2009.
Rui Yao, an assistant professor of personal financial planning in the College ...
NRL researchers observe bright arctic clouds formed by exhaust from final space shuttle launch
2012-08-28
Naval Research Laboratory (NRL) scientist Dr. Michael Stevens is leading an international consortium of scientists in tracking the rapid transport of the exhaust plume from the final launch of the space shuttle in July 2011. The team has found that the plume moved quickly to the Arctic, forming unusually bright polar mesospheric clouds (PMCs) there a day after launch.
Understanding the rapid transport of high altitude exhaust plumes near 105 km is providing new insight into the effects of winds at the bottom edge of the space weather regime towards improved forecasts ...
"For the Love of Scott!" by Jo Hamilton Tops 30,000 Readers
2012-08-28
Jo Hamilton took almost three decades to put her brother's tragic story on paper. In less than ten months, tens of thousands of readers have purchase her paperback book or downloaded the electronic version of For the Love of Scott!. People from the USA, the United Kingdom, Europe, and Asia bought or downloaded the book.
Scott Hamilton was a smart, talented and handsome Iowa farm boy awaiting a shot at a minor league baseball pitching career with the White Sox. His life was right on track. In an instant, Scott's dreams faded into his family's worst nightmare. His parents ...
Bridesandlovers.com - the Premier International Russian Dating Site for Men Seeking Russian Women - is Pleased to Announce Record Payments to its Affiliates in 2012
2012-08-28
Bridesandlovers.com - the premier international Russian dating site for men seeking marriage and romance with Russian women - is pleased to announce that earnings paid to partners of its affiliate program for 2012 have have increased 100% month on month. This affiliate program - which features a number of different payment plans and commission rates is considered by many to be one of best affiliate programs in the dating business. By signing up for this affiliate program at www.luvbucks.com and then advertising Bridesandlovers.com on their websites, affiliates can start ...
Biggest Kizomba Event in the USA - 2012 San Francisco Kizomba Festival Presented by Rodchata
2012-08-28
When Rodney Aquino started featuring Kizomba workshops in July 2009 at the 1st San Francisco Bachata Festival, a good amount of people were curious. This followed by 2nd Reno Bachata Festival where not only kizomba was featured and also Zouk Lambada. The Kizomba dance craze started to spread slowly but surely.
A kizomba class every Tuesday soon followed at the Glas Kat in San Francisco taught by Rodney Rodchata. There were like 10 to 12 participants.
Today, in the year 2012, the kizomba community in the Bay Area has grown and the buzz is stronger than before! Every ...
Cooled coal emissions would clean air and lower health and climate-change costs
2012-08-28
EUGENE, Ore. -- (Aug. 27, 2012) -- Refrigerating coal-plant emissions would reduce levels of dangerous chemicals that pour into the air -- including carbon dioxide by more than 90 percent -- at a cost of 25 percent efficiency, according to a simple math-driven formula designed by a team of University of Oregon physicists.
The computations for such a system, prepared on an electronic spreadsheet, appeared in Physical Review E, a journal of the American Physical Society.
In a separate, unpublished and preliminary economic analysis, the scientists argue that the "energy ...
Behind closed doors: Researchers show how probiotics boost plant immunity
2012-08-28
With the help of beneficial bacteria, plants can slam the door when disease pathogens come knocking, University of Delaware researchers have discovered.
A scientific team under the leadership of Harsh Bais, assistant professor of plant and soil sciences in UD's College of Agriculture and Natural Resources, found that when pathogens attempt to invade a plant through the tiny open pores in its leaves, a surprising ally comes to the rescue. Soil bacteria at the plant's roots signal the leaf pores to close, thwarting infection.
The fascinating defense response is documented ...
The effects of discrimination could last a lifetime
2012-08-28
Given the well-documented relationship between low birth weight and the increased risk of health problems throughout one's lifespan, it is vital to reduce any potential contributors to low birth weight. A new study by Valerie Earnshaw and her colleagues from Yale University sheds light on one possible causal factor. Their findings, published online in Springer's journal, the Annals of Behavioral Medicine, suggest that chronic, everyday instances of discrimination against pregnant, urban women of color may play a significant role in contributing to low birth weight babies.
Twice ...