PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Zebrafish study explains why the circadian rhythm affects your health

Zebrafish study explains why the circadian rhythm affects your health
2012-08-28
(Press-News.org) Disruptions to the circadian rhythm can affect the growth of blood vessels in the body, thus causing illnesses such as diabetes, obesity, and cancer, according to a new study from Linköping University and Karolinska Institutet in Sweden.

The circadian rhythm is regulated by a "clock" that reacts to both incoming light and genetic factors.

In an article now being published in the scientific journal Cell Reports, it is demonstrated for the first time that disruption of the circadian rhythm immediately inhibit blood vessel growth in zebra fish embryos.

Professor Yihai Cao leads a research group, which has demonstrated that the breaking point is the production of a very important signalling substance: vascular endothelial growth factor (VEGF). The formation of this substance requires a normal circadian rhythm.

During experiments with hours-old zebra fish embryos, the researchers manipulated their circadian rhythm through exposing them to lighting conditions varying from constant darkness to constant light. The growth of blood vessels in the various groups was then studied. The results showed that exposure to constant light (1800 lux) markedly impaired blood vessel growth; additionally, it affected the expression of genes that regulate the circadian clock.

"The results can definitely be translated into clinical circumstances. Individuals with disrupted circadian rhythms – for example, shift workers who work under artificial lights at night, people with sleeping disorders or a genetic predisposition – should be on guard against illnesses associated with disrupted blood vessel growth," says Lasse Dahl Jensen, researcher in Cardiovascular Physiology at Linköping University (LiU), and lead writer of the article.

Such diseases include heart attack, stroke, chronic inflammation, and cancer. Disruptions in blood vessel growth can also affect foetal development, women's reproductive cycles, and the healing of wounds.



INFORMATION:

Article:

Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish by L D Jensen, Z Cao, M Nakamura, Y Yang, L Bräutigam, P Andersson, Y Zhang, E Wahlberg, T Länne, K Hosaka and Y Cao. Cell Reports Online Now 9 Aug 2012.


[Attachments] See images for this press release:
Zebrafish study explains why the circadian rhythm affects your health

ELSE PRESS RELEASES FROM THIS DATE:

Global platelet reactivity and high risk ACS patients

2012-08-28
Global platelet reactivity is more effective than responsiveness to clopidogrel in identifying acute coronary syndrome (ACS) patients at high risk of ischemic events, according to research presented at ESC Congress 2012. The results from the RECLOSE 2-ACS study were presented by Dr Rossella Marcucci from the University of Florence. The Responsiveness to Clopidogrel and Stent thrombosis 2 – ACS (RECLOSE 2-ACS) study is a prospective, observational, referral centre cohort study of 1,789 patients with acute coronary syndromes undergoing percutaneous coronary intervention ...

Botany student proves 'New England Banksia' a distinct species

Botany student proves New England Banksia a distinct species
2012-08-28
The New England Banksia is largely restricted to the eastern edge of the New England Tableland, and is common in places along Waterfall Way. Ms Stimpson's research has raised this flowering plant, until now classified as a variety of the Hairpin Banksia (B. spinulosa), to the taxonomic level of a distinct species. The study was published in the open access journal PhytoKeys. "I love the Proteaceae – the family of flowering plants that includes the Banksia and Grevillea genera in Australia and Protea in South Africa," Ms Stimpson said. "Surprisingly, molecular evidence ...

Women 40% less likely to die after TAVI than men

2012-08-28
Munich, Germany – August 27 2012: Women with severe aortic stenosis are 40% less likely to die after transcatheter aortic valve implantation (TAVI) than men, reveals the latest data from the largest study to date of gender differences in outcomes after TAVI. The findings were presented at ESC Congress 2012 by Professor Karin Humphries from St. Paul's Hospital. More than 1.5 million people in the US suffer from aortic stenosis, a progressive disease where the aortic valve becomes obstructed, leading to life-threatening heart problems. If left untreated, half of all patients ...

TAVI improves quality of life in patients with severe aortic stenosis for at least 1 year

2012-08-28
Munich, Germany – August 28 2012: Transcatheter aortic valve implantation (TAVI) leads to meaningful improvements in health-related quality of life in patients with severe aortic stenosis that are maintained for at least 1 year, according to a study presented at ESC Congress 2012. The results from the German transcatheter aortic valve interventions registry were presented by Professor Till Neumann, MD, from Essen, Germany. Aortic stenosis is the most common valvular heart disease with increasing incidence especially with regard to the ageing of the population. Today, ...

Lifestyle changes could prevent 400 cardiac events and 200 deaths in Swedish PCI patients

2012-08-28
Munich, Germany – August 27 2012: Up to 400 cardiac events and 200 deaths in Swedish PCI patients could be avoided by following a heart healthy lifestyle, according to research from the SPICI study presented at ESC Congress 2012. The results were presented at ESC press conference by Professor Joep Perk from Linnaeus University and at the scientific session by Dr Roland CARLSSON. The benefits of adherence to a heart healthy lifestyle in combination with drug treatment after an acute myocardial infarction treated with coronary artery balloon intervention (PCI) have recently ...

Smoking after stroke increases death risk by 3-fold

2012-08-28
Munich, Germany – August 28 2012: Patients who resume smoking after a stroke increase their risk of death by three-fold, according to research presented at ESC Congress 2012 by Professor Furio Colivicchi from San Filippo Neri Hospital. The researchers also found that the earlier patients resume smoking, the greater their risk of death with one year. "It is well established that smoking increases the risk of having a stroke," said Professor Colivicchi. "Quitting smoking after an acute ischemic stroke may be more effective than any medication in reducing the risk of further ...

African research identifies strong candidate for possible single-dose malaria cure

2012-08-28
A recently discovered compound from the aminopyridine class not only has the potential to become part of a single-dose cure for all strains of malaria, but might also be able to block transmission of the parasite from person to person, according to a research collaboration involving the Medicines for Malaria Venture (MMV), based in Switzerland, and the Drug Discovery and Development Centre (H3-D) at the University of Cape Town, South Africa. On the basis of initial results it was selected by MMV for further development – making it the first compound researched on African ...

Personalized antiplatelet treatment improves outcome after PCI

2012-08-28
Munich, Germany – August 26 2012: Personalized antiplatelet treatment leads to better outcomes than standard antiplatelet treatment in patients undergoing coronary stent implantation, according to results from the MADONNA study presented at ESC Congress 2012. The findings were presented by Dr Jolanta Siller-Matula from Medical University of Vienna. Standard antiplatelet treatment in patients undergoing percutaneous coronary intervention (PCI) consists of a dual antiplatelet therapy with aspirin and an ADP receptor inhibitor such as clopidogrel. But measurements of platelet ...

30-day mortality after AMI drops with improved treatment

2012-08-28
Munich, Germany – August 28 2012: Improved treatment after acute myocardial infarction and less severe patient profile have reduced 30-day mortality over the past 15 years, according to research presented at ESC Congress 2012. The analysis of four French registries from 1995 to 2010 was presented by Professor Nicolas Danchin from the Hopital Européen Georges Pompidou. Cardiologists recognize two types of myocardial infarction. The first type, ST-elevation myocardial infarction (STEMI), corresponds to the sudden, permanent occlusion of a coronary artery supplying the myocardium ...

New method: Research team analyzes stress biology in babies

2012-08-28
After waking up, the concentration of the stress hormone cortisol in saliva rises considerably; this is true not only for grown-ups but for babies as well. A research team from the Ruhr-Universität Bochum and from Basel has reported this finding in the journal Psychoneuroendocrinology. "This gives us a new, non-invasive and uncomplicated possibility to already research the activity of the stress system during infancy," Prof. Dr. Gunther Meinlschmidt, of the Clinic of Psychosomatic Medicine and Psychotherapy at the LWL University Hospital of the RUB, said. The information ...

LAST 30 PRESS RELEASES:

The Lancet: Tens of thousands of children aged under five suffering acute malnutrition in Gaza, recent estimates suggest

Prostate testing may not target those most likely to benefit, warn experts

Global analysis shows hidden damage from men’s alcohol use

DRI recognizes Ashley Cornish as the 2025 Peter B. Wagner Memorial Award Winner for Women in Atmospheric Sciences

Unlocking the blueprint for a powerful plant-based drug

Bringing modern science to vitamin biology: Isha Jain wins NIH Transformative Research Award

University of Houston scientists learn that rare bacterium ‘plays dead’ to survive

Introduced animals change how island plants spread, new global study finds

Mayo Clinic researchers discover ‘traffic controller’ protein that protects DNA, and may help kill cancer cells

Protein sidekick exhibits dual roles in stress granule assembly and disassembly

New hope for MS

Kennesaw State professor receives grant to study cancer origins

Pain and antidepressant drug combo linked to increased seizure risk in older adults

Cancer researchers shape new strategies for immunotherapy

Physical exercise can ‘train’ the immune system

Calm red brocket deer can learn to "Come" and other commands - but the flightiest, most restless individuals struggle

China, the world's largest tea producer, is predicted to experience increases in land suitable for tea-growing under climate change, with the overall range shifting northwards, per AI modeling study

Composing crews for Mars missions

Early humans butchered elephants using small tools and made big tools from their bones

1,000-year-old gut microbiome revealed for young man who lived in pre-Hispanic Mexico

Bears and pandas in captivity develop significantly different gut microbiomes compared to their wild counterparts, and giant pandas in particular have less diverse microbiomes than their wild counterp

Prenatal and postnatal support apps might not work

Dancing dust devils trace raging winds on Mars

Raging winds on Mars

Real-time biopsies uncover hidden response to glioblastoma therapy

Repeated brain tumor sampling uncovers treatment response in patients with glioblastoma

Novel immunotherapy combination destroys colorectal liver metastases

Farmed totoaba could curb poaching

Avalanches: user-carried safety device increases survival time fivefold

It’s all in your head: Select neurons in the brainstem may hold the key to treating chronic pain

[Press-News.org] Zebrafish study explains why the circadian rhythm affects your health