BUSM researchers study use of MRI in osteoarthritis

(Press-News.org) (Boston) – A study conducted by researchers at Boston University School of Medicine (BUSM) shows that magnetic resonance imaging (MRI) detected a high prevalence of abnormalities associated with knee osteoarthritis in middle-aged and elderly patients that had no evidence of knee osteoarthritis in X-ray images.

Ali Guermazi, MD, PhD, professor of radiology at BUSM and chief of Musculoskeletal Imaging at Boston Medical Center (BMC), led this study in collaboration with researchers from Lund University in Sweden, Brigham and Women's Hospital in Boston and Klinikum Augsburg in Germany. The findings are published online in BMJ.

Osteoarthritis, the most common form of arthritis, is characterized by a degeneration of cartilage and the underlying bone and other soft tissues in the joints, leading to pain and stiffness. According to the Centers for Disease Control and Prevention, osteoarthritis is the leading cause of disability in the United States, affecting approximately 26.9 million Americans. It is responsible for a significant portion of primary care visit and hospitalizations and has a large financial impact on health care. With the aging population, it is anticipated that the prevalence of osteoarthritis will continue to increase.

Prior studies have shown that only half of those with knee pain will have X-ray evidence of osteoarthritis. This study looked at how to further evaluate a patient's knee pain if X-rays don't show evidence of osteoarthritis. It also looked at whether MRI, in these cases, is of clinical value.

This observational study looked at the prevalence of MRI-detected abnormalities in a group of adults over the age of 50 who had no signs of knee osteoarthritis in X-ray images. The researchers looked at right knee MRIs of 710 ambulatory patients from the Framingham Osteoarthritis Study. Further analysis was performed on groups by age, gender, body mass index and the presence or absence of knee pain.

The results showed that approximately 90 percent of the knees that showed no signs of osteoarthritis using X-ray showed clear signs of osteoarthritis using MRI. In addition, MRI abnormalities were highly prevalent even in persons whose knees were not painful, suggesting that MRI was not a useful diagnostic test in this age group to evaluate knee pain.

"This data demonstrates a very high prevalence of MRI-detected osteoarthritis features in knees with no X-ray evidence of the disease," said Guermazi. "While the MRI could be detecting early-stage osteoarthritis, further research is needed to determine what proportion of these individuals are diagnosed with knee osteoarthritis later in life."

The researchers mention that MRI would be too expensive to perform as a routine imaging investigation.

### Other BUSM researchers involved with this study include David Felson, MD, MPH, professor of medicine and epidemiology and principal investigator of the Framingham Osteoarthritis Study; Daichi Hayashi, MD, PhD, research assistant professor of radiology and Jingbo Niu, DSc, research assistant professor of medicine.

This research study was supported by grants from the National Institute of Aging under award number AG18393, the National Institute of Arthritis and Musculoskeletal and Skin Diseases under award number AR47785 and the Arthritis Foundation.

*Daniel Kirshenbaum, MD contributed to this press release.