Interventions needed to promote healthy behaviors among perinatally HIV-infected youth

(Press-News.org) As youth infected at birth with HIV reach adolescence and young adulthood, a new study published in Clinical Infectious Diseases underscores the need to promote healthy behaviors as some of these young people become sexually active.

Like other adolescents, some of the 330 young people in the study (from 15 sites across the U.S.) have initiated sexual activity, with many reporting having unprotected sex. Of the youth who were asked about disclosure of their HIV status to their first sexual partners, the majority reported that they had not disclosed to their partner prior to sexual activity, researchers found. While sexual activity is not uncommon among adolescents, HIV-infected or not, "HIV infection adds another level of complexity to the adolescence of youth who are infected and has implications for both their own health and that of their sexual partners," said lead study author Katherine Tassiopoulos, DSc, MPH, of the Harvard School of Public Health.

The link between not following regimens for antiretroviral therapy (ART) medications — known as non-adherence—and risky sexual behaviors, already recognized among HIV-positive adults, is just now coming to light in adolescents as this cohort emerges from childhood. "Among youth, both non-adherence and sexual initiation may be expressions of independence or of the desire to feel accepted by peers," the authors noted. Successful interventions may account for adolescents' growing desire for independence by encouraging medication adherence, disclosure, and condom use as behaviors that will protect the health of their sexual partners as well as their own.

Early action by clinicians can help prepare these youth to make choices that reduce risk to themselves and to their partners. A critical step is informing youth of their HIV status. In this study, 18 percent of the participants were unaware they were HIV-positive at the time they started sexual activity. Clinicians and families should ensure that young people with HIV are informed of their HIV status prior to or during early adolescence, according to current guidelines for disclosure of HIV infection to children and adolescents.

Researchers found that among sexually active youth with high viral load (> 5,000 copies/ml), 81 percent had drug-resistant virus. This raises the possibility of resistant virus being transmitted to sexual partners and also limits treatment options for infected youth. Author George R. Seage III, DSc, MPH, also of the Harvard School of Public Health, believes that one critical step in encouraging optimal adherence may be informing young people "that ART can dramatically reduce the likelihood of sexual transmission of HIV."

Although the three-pronged message—safer sex practices, disclosure of HIV status to sexual partners, and adherence to ART regimens—is not new, targeted and innovative intervention strategies are needed to reach this important group of adolescents and reinforce healthy behaviors, the team of authors concluded.

### The study is available online. It is embargoed until 12:01 a.m. EDT on Thursday, Nov. 8, 2012:

Sexual Risk Behavior Among Youth With Perinatal HIV Infection in the United States: Predictors and Implications for Intervention Development Clinical Infectious Diseases is a leading journal in the field of infectious disease with a broad international readership. The journal publishes articles on a variety of subjects of interest to practitioners and researchers. Topics range from clinical descriptions of infections, public health, microbiology, and immunology to the prevention of infection, the evaluation of current and novel treatments, and the promotion of optimal practices for diagnosis and treatment. The journal publishes original research, editorial commentaries, review articles, and practice guidelines and is among the most highly cited journals in the field of infectious diseases. Clinical Infectious Diseases is an official publication of the Infectious Diseases Society of America (IDSA). Based in Arlington, Va., IDSA is a professional society representing nearly 10,000 physicians and scientists who specialize in infectious diseases. For more information, visit www.idsociety.org.