(Press-News.org) New Rochelle, NY, November 13, 2012—Following an infection, dysregulation of the immune system can result in a systemic inflammatory response and an often fatal condition called severe sepsis or septic shock. Sepsis is not uncommon, yet its cause and underlying immune dysfunction remain poorly understood. Regulatory T cells (Tregs), a component of the immune system, now appear to have an important role in suppressing the immune response in advance of sepsis, and understanding this role may lead to new therapeutic strategies for improving patient outcomes, as described in a review article in Journal of Interferon & Cytokine Research, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free online on the Journal of Interferon & Cytokine Research website.
Li-Na Jiang, Yong-Ming Yao, and Zhi-Yong Sheng, Chinese PLA General Hospital, Beijing, and Hebei North University, Zhyangjiakou, China, review the growing body of literature supporting a link between alterations in Treg function and the development of sepsis, based on animal studies and preliminary human studies. In the article "The Role of Regulatory T Cells in the Pathogenesis of Sepsis and Its Clinical Implications (http://online.liebertpub.com/doi/full/10.1089/jir.2011.0080)," the authors suggest that accumulating experimental and clinical evidence indicates that manipulating Tregs may offer a promising strategy for treating patients with septic shock.
"Regulatory T cells are receiving much attention as important determinants of both beneficial and detrimental immune responses," says Co-Editor-in-Chief Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation. "This review brings focus to the function of this important cell population in the context of sepsis, a condition more frequently associated with innate immunity."
INFORMATION:
About the Journal
Journal of Interferon & Cytokine Research, led by Co-Editors-in-Chief Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation, and Thomas A. Hamilton, PhD, is an authoritative peer-reviewed journal published monthly in print and online that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is the official journal of the International Society for Interferon and Cytokine Research. Complete tables of content and a sample issue may be viewed online on the Journal of Interferon & Cytokine Research website.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Viral Immunology, AIDS Research and Human Retroviruses, and DNA and Cell Biology. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.
Are we closer to understanding the cause of deadly sepsis?
2012-11-16
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Gene distinguishes early birds from night owls and helps predict time of death
2012-11-16
BOSTON – Many of the body's processes follow a natural daily rhythm or so-called circadian clock. There are certain times of the day when a person is most alert, when blood pressure is highest, and when the heart is most efficient. Several rare gene mutations have been found that can adjust this clock in humans, responsible for entire families in which people wake up at 3 a.m. or 4 a.m. and cannot stay up much after 8 at night. Now new research has, for the first time, identified a common gene variant that affects virtually the entire population, and which is responsible ...
ORNL recipe for oxide interface perfection opens path to novel materials
2012-11-16
By tweaking the formula for growing oxide thin films, researchers at the Department of Energy's Oak Ridge National Laboratory achieved virtual perfection at the interface of two insulator materials.
This finding, published in the journal Advanced Materials, could have significant ramifications for creation of novel materials with applications in energy and information technologies, leading to more efficient solar cells, batteries, solid oxide fuel cells, faster transistors and more powerful capacitors.
The research team, led by ORNL's Ho Nyung Lee, demonstrated that ...
Teenagers urged to exercise to ward off bone disease
2012-11-16
An international team, including an expert from the University of Exeter, has found evidence that adolescents who spend long periods engaged in certain sedentary activities are more likely to have low bone mineral content in parts of the body where it can be an indicator of the risk of developing osteoporosis.
In the research, published by PubMed on November 15, the team found that studying put girls at particular risk, while for boys leisure internet use posed the greatest threat. Scientists found that participating in at least three hours of certain sports could significantly ...
How does groundwater pumping affect streamflow?
2012-11-16
Groundwater provides drinking water for millions of Americans and is the primary source of water to irrigate cropland in many of the nations most productive agricultural settings. Although the benefits of groundwater development are many, groundwater pumping can reduce the flow of water in connected streams and rivers—a process called streamflow depletion by wells. The USGS has released a new report that summarizes the body of knowledge on streamflow depletion, highlights common misconceptions, and presents new concepts to help water managers and others understand the effects ...
USDA funded research leads to key discoveries in the pig genome
2012-11-16
WASHINGTON, Nov. 15, 2012 – Research conducted and supported by the U.S. Department of Agriculture (USDA) has led to a new analysis of the pig genome, revealing new similarities between pigs and humans that could potentially advance biomedical research significantly. Additional findings from the study, reported today in the journal Nature, may also lead to better breeding strategies, improved pork production and improvements to human health. The research was conducted by a global team of scientists as part of the International Swine Genome Sequence Consortium (ISGSC).
"This ...
New research explores why we remember and why we forget
2012-11-16
Psychological scientists are exploring the mechanisms that underlie memory to understand why we remember certain things and why we forget others. Read about the latest research on memory published in the November 2012 issue of Psychological Science.
Retrieval-Induced Forgetting Predicts Failure to Recall Negative Autobiographical Memories
Failure to retrieve memories may not always be a bad thing - we might, for example, prefer to forget about certain instances of heartbreak or failure in favor of some of the more positive events from our lives. In this study, researchers ...
Fire the coach? Not so fast, says new study by University of Colorado, Loyola professors
2012-11-16
Fire the coach? Not so fast says a new study of elite college football teams.
Professors from the University of Colorado and Loyola University Chicago studied what happened to the records of college football teams that replaced a head coach for performance reasons in the Football Bowl Subdivision (formerly Division 1-A) between 1997 and 2010. Over this period, an average of 10 percent of FBS teams fired their coach each year because of the team's poor performance on the field.
The authors used statistical methods to compare groups of teams that were similar except for ...
New whale shark study used metabolomics to help understand shark and ray health
2012-11-16
New research from Georgia Aquarium and Georgia Institute of Technology provides evidence that a suite of techniques called "metabolomics" can be used to determine the health status of whale sharks (Rhincodon typus), the world's largest fish species. The study, led by Dr. Alistair Dove, Director of Research & Conservation at Georgia Aquarium and an adjunct professor at Georgia Tech, found that the major difference between healthy and unhealthy sharks was the concentration of homarine in their in serum—indicating that homarine is a useful biomarker of health status for the ...
$20 million CU-Boulder instrument package set for integration on Mars spacecraft
2012-11-16
A $20 million remote sensing instrument package built by the University of Colorado Boulder, which is leading a 2013 NASA mission to understand how Mars might have lost its atmosphere, has been delivered to Lockheed Martin in Littleton, Colo., for spacecraft integration.
The remote sensing package designed and built by CU-Boulder's Laboratory for Atmospheric and Space Physics consists of the Imaging UltraViolet Spectrograph, or IUVS, as well as its electronic control box, the Remote Sensing Data Processing Unit, or RSDPU, both under contract to NASA Goddard Spaceflight ...
CSA group and IPAC-CO2 announce world's first standard for geologic storage of carbon dioxide
2012-11-16
Regina & Toronto, November 15, 2012 – CSA Group, a leading developer of standards, codes and training programs, and the International Performance Assessment Centre for Geologic Storage of Carbon Dioxide (IPAC-CO2 Research Inc.), an environmental non-government organization (ENGO), today announced the world's first bi-national carbon capture and storage (CCS) standard for the geologic storage of carbon dioxide (CO2) for Canada and the United States.
CCS is a process consisting of the separation of CO2 from industrial and energy-related sources, transport to a storage ...