PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

New methods for quantifying antisense drug delivery to target cells and tissues

New methods for quantifying antisense drug delivery to target cells and tissues
2013-02-02
(Press-News.org) New Rochelle, NY, January 31, 2012—Powerful antisense drugs that target disease-associated genes to block their expression can be used to treat a broad range of diseases. Though antisense therapy has been proven effective, challenges remain in ensuring that the drugs reach their intended targets. Two new methods for detecting and measuring the levels of antisense drugs in cells that could accelerate the development of improved antisense drugs are described in an article in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available on the BioResearch Open Access website.

In the article "Development of Novel Bioanalytical Methods to Determine the Effective Concentrations of Phosphorodiamidate Morpholino Oligomers in Tissues and Cells," Frederick Schnell, Stacy Crumley, Dan Mourich, and P.L. Iversen, from Sarepta Therapeutics and Oregon State University (Corvallis, OR), describe two fast and sensitive methods for detecting a promising type of antisense therapeutic called a phosphorodiamidate morpholine oligomer, or PMO. Using these novel methods they were able to detect PMO delivery to individual cells and quantify how much PMO resides in a particular tissue in the body, such as the lung. For example, the authors describe the measurement of intranasally delivered PMO in lung tissue and, more specifically, in different cell types in the lung. They were able to measure the clearance kinetics of the PMO and determine whether it stayed in the lung tissue.

"The development of novel, rapid PMO detection techniques such as these will advance the field of PMO research in a significant way, providing valid alternatives to the current time-consuming and labor-intensive methods," says Editor-in-Chief Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland.



INFORMATION:

About the Journal

BioResearch Open Access is a bimonthly peer-reviewed open access journal that provides a new rapid-publication forum for a broad range of scientific topics including molecular and cellular biology, tissue engineering and biomaterials, bioengineering, regenerative medicine, stem cells, gene therapy, systems biology, genetics, biochemistry, virology, microbiology, and neuroscience. All articles are published within 4 weeks of acceptance and are fully open access and posted on PubMedCentral. All journal content is available on the BioResearch Open Access website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative medical and biomedical peer-reviewed journals, including Metabolic Syndrome and Related Disorders, Population Health Management, Diabetes Technology & Therapeutics, and Journal of Women's Health. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, newsmagazines, and books is available on the Mary Ann Liebert, Inc., publishers website at http://www.liebertpub.com.

Mary Ann Liebert, Inc. 140 Huguenot Street, New Rochelle, NY 10801-5215 www.liebertpub.com
Phone (914) 740-2100 (800) M-LIEBERT Fax (914) 740-2101
www.liebertpub.com


[Attachments] See images for this press release:
New methods for quantifying antisense drug delivery to target cells and tissues

ELSE PRESS RELEASES FROM THIS DATE:

Trauma patients, community say they support exception from informed consent research

2013-02-02
PHILADELPHIA — Traumatic injury – including car accidents, gunshot wounds, and stabbings – is the leading cause of death for people younger than 40 years old in the United States, but despite the toll of these injuries, few emergency medical interventions considered to be the standard of care for these injuries have been rigorously studied in clinical trials, because patients and their families are typically unable to consent to participate in research. A new study from the Perelman School of Medicine at the University of Pennsylvania sought to examine peoples' willingness ...

Moffitt Cancer Center researchers develop automated breast density test linked to cancer risk

2013-02-02
Researchers at Moffitt Cancer Center and colleagues at the Mayo Clinic in Rochester, Minn., have developed a novel computer algorithm to easily quantify a major risk factor for breast cancer based on analysis of a screening mammogram. Increased levels of mammographic breast density have been shown in multiple studies to be correlated with elevated risk of breast cancer, but the approach to quantifying it has been limited to the laboratory setting where measurement requires highly skilled technicians. This new discovery opens the door for translation to the clinic where ...

Inaugural issue of the NYU College of Dentistry's JADE online now

2013-02-02
New York University College of Dentistry (NYUCD) is delighted to introduce the inaugural issue of the Journal of the Academy of Distinguished Educators (JADE), published by NYUCD. JADE can be accessed by going to http://www.nyu.edu/dental/ade/. An online-only, open-access journal, JADE is the publications component of the NYU Academy of Distinguished Educators. The mission of the Academy is to enhance overall teaching at NYUCD and to stimulate excitement among teachers around their intellectual content. JADE intends to invite experts in higher education to face off ...

Humanitarian aid workers in Uganda show signs of stress, depression, and burnout

2013-02-02
Latest research points to the high risk for mental health problems among staff working in humanitarian organizations in northern Uganda, due in large part to their work environment. A new study by researchers at Columbia's Mailman School of Public Health examined the mental health of 376 Ugandan workers at 21 humanitarian aid agencies and found that a significant number of the staff at these organizations experienced high levels of symptoms for depression (68%), anxiety disorders (53%), and posttraumatic stress disorder (PTSD) (26%), respectively. Research up to now ...

Recent Study Indicates Serious Surgical Errors Occur 4,000 Times Each Year

2013-02-02
Recent Study Indicates Serious Surgical Errors Occur 4,000 Times Each Year Each day, patients put their trust in surgeons to perform life-saving operations. Although most of these surgeries occur without incident, a new study, recently published in the journal Surgery, indicates that thousands of serious surgical errors occur each year. Researchers at the Johns Hopkins University School of Medicine examined 20 years of data from the National Practitioner Data Bank (NPDB), a federally created database of medical malpractice claim information, to identify judgments ...

Group Calls for Tougher Traffic Safety Laws

2013-02-02
Group Calls for Tougher Traffic Safety Laws Over the last ten years, the number of traffic fatalities in the United States has fallen to record lows. A variety of factors, including better road conditions, improved vehicle safety standards and public awareness campaigns against behaviors such as drunk driving have all contributed to safer roadways. Because of a recent increase in the number of fatal car accidents, however, one safety group suggests that years of declining road deaths has led to complacency among lawmakers. Number of Fatalities Increasing? According ...

Crane Operator and Owner Cited in Latest New York Construction Accident

2013-02-02
Crane operator and owner cited in latest New York construction accident Lately it may seem like dangerous construction accidents such as crane collapses are an almost constant occurrence in New York City. Following the latest crane collapse, the crane operator and owner were cited by the New York City Department of Buildings for violations, and many hope increased regulations and enforcement will reduce the number of these perilous incidents. New York City crane accidents According to WABC News, there have been five serious crane accidents in New York in less than ...

Even With New Technologies, Using Cell Phone While Driving Remains Dangerous

2013-02-02
Even With New Technologies, Using Cell Phone While Driving Remains Dangerous In recent years, the increased adoption of smart phone and Global Positioning System (GPS) technology has changed the way people drive. Indeed, these new devices help commuters keep in touch with loved ones and help ensure they reach their planned destinations. The use of cell phones while driving does, however, come with significant risks. And although some auto manufacturers have attempted to mitigate these risks with new technologies, the danger still remains. Distracted Driving a Significant ...

Operation Safe Driver Has Lessons for all Motorists

2013-02-02
Operation Safe Driver has lessons for all motorists In October West Virginia took part in a North American campaign, Operation Safe Driver. Originally designed to promote highway safety for commercial vehicles, the program aims to make roads in the United States, Canada and Mexico safer for all motorists. Sponsors of the annual event are the Commercial Vehicle Safety Alliance and the Federal Motor Carrier Safety Administration. Focus of Operation Safe Driver The CVSA stated that its focus in the 2012 Operation Safe Driver initiative was on three kinds of unsafe ...

Loan Servicers Agree to Settlement, Help Homeowners Keep Homes

2013-02-02
Loan servicers agree to settlement, help homeowners keep homes Loan servicers like Bank of America, Citigroup, JPMorgan Chase and Wells Fargo recently agreed to a $25 billion settlement for borrowers struggling to keep their homes. The settlement was made with a group of state attorneys general. These banks, along with other loan providers, were charged with wrongful foreclosure and other deceptive practices like taking illegal shortcuts when foreclosing on a homeowner's property, according to Fox Business. According to the executive summary, the settlement is ...

LAST 30 PRESS RELEASES:

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

Mission accomplished for the “T2T” Hong Kong Bauhinia Genome Project

Study identifies how malaria can lead to childhood cancer

An earth-abundant mineral for sustainable spintronics

What makes successful learners? How Minecraft can helps us understand social learning

Researchers create ‘super stem cells’, seeing potential for improved fertility treatment

Empathic comforting varies more within bonobo and chimpanzee species than between them

AACR 2025: Colon cancer risk reduction, predicting melanoma spread and new drug therapies among Ohio State findings

Landmark 20-year screening program drives down colorectal cancer cases, deaths

Can a baby’s DNA predict future disease? This study says it might

Gene mutations linked to worse outcomes in stomach cancer

Blood proteins can predict liver disease up to 16 years before symptoms

Study: New DNA-reading technology holds promise for rare disease research

[Press-News.org] New methods for quantifying antisense drug delivery to target cells and tissues