(Press-News.org) Researchers from the universities of Granada and Murcia have confirmed the effectiveness of a spray containing 1% malic acid, which greatly improves xerostomy, or dry mouth, caused by anti-depressant drugs. This product, combined with xylitol and fluorides, in a spray format, stimulates saliva production in patients with this illness, thus improving their quality of life.
Xerostomy is a dry-mouth sensation that patients have, often caused by reduced salivary secretion or biochemical changes in the saliva itself. Patients with xerostomy often find difficulty in chewing, swallowing or even talking. It is a subjective sensation, whilst hyposalivation refers to an actual reduction in salivary flow, meaning that it is objective and, therefore, quantifiable.
As the main author of this study, University of Granada lecturer, Gerardo Gomez Moreno, explains, one of the main causes of dry mouth is the consumption of different medications. "There are over 500 drugs, belonging to 42 pharmacological groups, which can provoke xerostomy as a side effect. Those that are most related are anti-depressants, the prescription of which has increased over recent years, thus leading to a higher number of patients with xerostomy from taking anti-depressive drugs, above all in 45-50 year olds".
Clinical trial using 70 patients
The University of Granada research was carried out in a double-blind randomized clinical trial on 70 patients diagnosed with anti-depressant-induced xerostomy, split into two (2) groups. The first group of 35 patients took a sialogogue mouth spray (1% malic acid), while the second group – also consisting of 35 patients – received a placebo. Both products were applied on demand over two (2) weeks. To check the xerostomy both before and after applying both the product and the placebo, the researchers used a specific questionnaire, called the Dry Mouth Questionnaire (DMQ).
Dr. Gomez Moreno points out that are various therapeutic possibilities for treating xerostomy (sialogogues, salivary substitutes, other general treatments), "although the effectiveness of many of them are controversial. For example, some studies have described citric and malic acid as salivary stimulants, even though, for years, their use was rejected due to the possible de-mineralizing effect on tooth enamel". However, recent research has shown that there is a reduction in the potential de-mineralizing effect of malic acid when used in the correct concentration and when combined with xylitol and fluorides.
INFORMATION:
The University of Granada researchers, who belong to the "Pharmacological Research Group into Dentistry CTS-654", backed by the Andalusian Regional Government, have published their results in the latest edition of the Official American Journal on Depression and Anxiety.
References:
The efficacy of a topical sialogogue spray containing 1% malic acid in patients with antidepressant-induced dry mouth: A double-blind, randomized clinical trial
Gomez-Moreno, G , Aguilar-Salvatierra, A., Guardia, J., Uribe-Marioni, A., Cabrera-Ayala, M., Delgado-Ruiz, R.A., Calvo-Guirado, J.L. Depression and Anxiety
Volume 30, Issue 2, February 2013, Pages 137-142
The full article can be consulted at: http://sl.ugr.es/03zw
Effectiveness of a spray that greatly improves dry mouth sensation caused by anti-depressants
Patients with dry mouth often have difficulty chewing, swallowing or even talking and their numbers have increased in recent years, due to a rise in taking medication, above all anti-depressants
2013-04-03
ELSE PRESS RELEASES FROM THIS DATE:
CWRU-led scientists build material that mimics squid beak
2013-04-03
Researchers led by scientists at Case Western Reserve University have turned to an unlikely model to make medical devices safer and more comfortable—a squid's beak.
Many medical implants require hard materials that have to connect to or pass through soft body tissue. This mechanical mismatch leads to problems such as skin breakdown at abdominal feeding tubes in stroke patients and where wires pass through the chest to power assistive heart pumps. Enter the squid.
The tip of a squid's beak is harder than human teeth, but the base is as soft as the animal's Jello-like ...
Verifying that sorghum is a new safe grain for people with celiac disease
2013-04-03
Strong new biochemical evidence exists showing that the cereal grain sorghum is a safe food for people with celiac disease, who must avoid wheat and certain other grains, scientists are reporting. Their study, which includes molecular evidence that sorghum lacks the proteins toxic to people with celiac disease, appears in ACS' Journal of Agricultural and Food Chemistry.
Paola Pontieri and colleagues explain that those gluten proteins, present in wheat and barley, trigger an immune reaction in people with celiac disease that can cause abdominal pain and discomfort, constipation, ...
Earth is 'lazy' when forming faults like those near San Andreas
2013-04-03
AMHERST, Mass. – Geoscientist Michele Cooke and colleagues at the University of Massachusetts Amherst take an uncommon, "Earth is lazy" approach to modeling fault development in the crust that is providing new insights into how faults grow. In particular, they study irregularities along strike-slip faults, the active zones where plates slip past each other such as at the San Andreas Fault of southern California.
Until now there has been a great deal of uncertainty among geologists about the factors that govern how new faults grow in regions where one plate slides past ...
New view of origins of eye diseases
2013-04-03
Using new technology and new approaches, researchers at Lund University in Sweden hope to be able to explain why people suffer vision loss in eye diseases such as retinal detachment and glaucoma.
Research on diseases of the eye such as retinal detachment and glaucoma has until now focused on the biochemical process that takes place in the eye in connection with the diseases.
Fredrik Ghosh and Linnéa Taylor have concentrated instead on attempting to understand what happens on a biomechanical level in the diseases and have produced results that have drawn a lot of interest ...
Taken under the 'wing' of the small magellanic cloud
2013-04-03
The Small Magellanic Cloud (SMC) is one of the Milky Way's closest galactic neighbors. Even though it is a small, or so-called dwarf galaxy, the SMC is so bright that it is visible to the unaided eye from the Southern Hemisphere and near the equator. Many navigators, including Ferdinand Magellan who lends his name to the SMC, used it to help find their way across the oceans.
Modern astronomers are also interested in studying the SMC (and its cousin, the Large Magellanic Cloud), but for very different reasons. Because the SMC is so close and bright, it offers an opportunity ...
Anxiety about retirement -- for aging nuclear power plants
2013-04-03
Mention "high costs," "financing" and "safety" in the same sentence as "commercial nuclear power plants," and most people think of the multi-billion-dollar construction or operational phase of these facilities, which provide 20 percent of the domestic electric supply. Those concerns, however, are now emerging as aging nuclear power plants reach retirement age, and electric utilities confront the task of deconstruction, or decommissioning, nuclear power stations. That's the topic of the cover story in the current edition of Chemical & Engineering News, the weekly newsmagazine ...
Dental anesthesia may interrupt development of wisdom teeth in children
2013-04-03
BOSTON (April 3, 2013) — Researchers from Tufts University School of Dental Medicine have discovered a statistical association between the injection of local dental anesthesia given to children ages two to six and evidence of missing lower wisdom teeth. The results of this epidemiological study, published in the April issue of The Journal of the American Dental Association, suggest that injecting anesthesia into the gums of young children may interrupt the development of the lower wisdom tooth.
"It is intriguing to think that something as routine as local anesthesia could ...
Urinary tract infections 29 times more likely in schizophrenia relapse
2013-04-03
AUGUSTA, Ga. – Schizophrenia patients experiencing relapse are 29 times more likely than healthy individuals to have a urinary tract infection, researchers report.
Urinary tract infections, which can cause painful and frequent urination, are common but patients hospitalized for schizophrenia are even more likely to have a UTI than healthy individuals or even others whose illness is under control, said Dr. Brian J. Miller, psychiatrist and schizophrenia expert at the Medical College of Georgia at Georgia Regents University.
The study comparing UTI rates in 57 relapsed ...
Choosing less a form of protection says new study on decision-making
2013-04-03
Toronto – Imagine you have a choice to make.
In one scenario, you'd get $8 and somebody else -- a stranger – would get $8 too. In the other, you'd get $10; the stranger would get $12.
Economists typically assume you'd go for the $10/$12 option because of the belief that people try to maximize their own gains. Choosing the other scenario would just be irrational.
But new research conducted in collaboration with a professor at the University of Toronto's Rotman School of Management shows that if a person is feeling threatened, or concerned with their status, they are ...
Smoking and depressive symptoms in adolescent girls are 'red flag' for postmenopausal osteoporosis
2013-04-03
Philadelphia, PA, April 3, 2013 – Depression, anxiety, and smoking are associated with lower bone mineral density (BMD) in adults, but these factors have not previously been studied during adolescence, when more than 50% of bone accrual occurs. This longitudinal preliminary study is the first to demonstrate that smoking and depressive symptoms in adolescent girls have a negative impact on adolescent bone accrual and may become a red flag for a future constrained by low bone mass or osteoporosis and higher fracture rates in postmenopausal years. The study is published in ...
LAST 30 PRESS RELEASES:
Greener and cleaner: Yeast-green algae mix improves water treatment
Acquired immune thrombotic thrombocytopenic purpura (TTP) associated with inactivated COVID-19 vaccine CoronaVac
CIDEC as a novel player in abdominal aortic aneurysm formation
Artificial intelligence: a double-edged sword for the environment?
Current test accommodations for students with blindness do not fully address their needs
Wide-incident-angle wideband radio-wave absorbers boost 5G and beyond 5G applications
A graph transformer with boundary-aware attention for semantic segmentation
C-Path announces key leadership appointments in neurodegenerative disease research
First-of-its-kind analysis of U.S. national data reveals significant disparities in individual well-being as measured by lifespan, education, and income
Exercise programs help cut new mums’ ‘baby blues’ severity and major depression risk
Gut microbiome changes linked to onset of clinically evident rheumatoid arthritis
Signals from the gut could transform rheumatoid arthritis treatment
Pioneering research reveals some of the world’s least polluting populations are at much greater risk of flooding fuelled by climate change
UK’s health data should be recognized as critical national infrastructure, says independent review
A 36-gene predictive score of anti-cancer drug resistance anticipates cancer therapy outcomes
Someone flirts with your spouse. Does that make your partner appear more attractive?
Hourglass-shaped stent could ease severe chest pain from microvascular disease
United Nations ratifies framework to protect people on cash app
Oklahoma State basketball team joins the Nation of Lifesavers
Power of aesthetic species on social media boosts wildlife conservation efforts, say experts
Researchers develop robotic sensory cilia that monitor internal biomarkers to detect and assess airway diseases
Could crowdsourcing hold the key to early wildfire detection?
Reconstruction of historical seasonal influenza patterns and individual lifetime infection histories in humans based on antibody profiles
New study traces impact of COVID-19 pandemic on global movement and evolution of seasonal flu
Presenting a Janus channel of membranes for complete oil-and-water separation
COVID-19 restrictions altered global dispersal of influenza viruses
Disconnecting hepatic vagus nerve restores balance to liver and brain circadian clocks, reducing overeating in mice
Mechanosensory origins of “wet dog shakes” – a tactic used by many hairy mammals – uncovered in mice
New study links liver-brain communication to daily eating patterns
Defense or growth – How plants allocate resources
[Press-News.org] Effectiveness of a spray that greatly improves dry mouth sensation caused by anti-depressantsPatients with dry mouth often have difficulty chewing, swallowing or even talking and their numbers have increased in recent years, due to a rise in taking medication, above all anti-depressants