Pregnant women with chronic hypertension (high blood pressure) are highly likely to suffer from adverse pregnancy outcomes such as preterm delivery, low birth weight and neonatal death, which highlights a need for heightened surveillance, suggests a paper published on bmj.com today. Chronic hypertension complicates between 1-5% of pregnancies, and the problem may be increasing because of changes in the antenatal population. A recent study in the US suggests the prevalence of chronic hypertension increased from 1995-1996 to 2007-2008, after adjustment for maternal ...

A functional brain imaging technique known as positron emission tomography (PET) is a promising tool for determining which severely brain damaged individuals in vegetative states have the potential to recover consciousness, according to new research published in The Lancet. It is the first time that researchers have tested the diagnostic accuracy of functional brain imaging techniques in clinical practice. "Our findings suggest that PET imaging can reveal cognitive processes that aren't visible through traditional bedside tests, and could substantially complement standard ...

A new study has shed light on the factors likely to lead to the development of a rare condition affecting the inner ear. In the most comprehensive study of Ménière's Disease to date, researchers at the University of Exeter Medical School have been able to suggest what goes wrong in the body when people develop the disease, and provide an insight into factors that lead to its development. Ménière's Disease can cause tinnitus, hearing loss, vertigo attacks and a feeling of pressure deep within the ear. Yet as a long term but non-fatal illness, it has received little attention ...

Antibiotics improve growth in children at risk of undernourishment in low and middle income countries, according to researchers at McGill University who have just conducted a research literature review on the subject. Their results, published in the British Medical Journal, suggest that the youngest children from the most vulnerable populations benefit most and show significant improvements toward expected growth for their age and sex, particularly for weight. Malnutrition in early childhood, reflected in poor growth, is the cause of nearly half of all mortality worldwide ...

Over 20 years after the fatal fialuridine trial, a study published this week in PLOS Medicine demonstrates that mice with humanized livers recapitulate the drug's toxicity. The work suggests that this mouse model should be added to the repertoire of tools used in preclinical screening of drugs for liver toxicity before they are given to human participants in clinical trials. A retrospective analysis by the US National Academy of Sciences of all preclinical fialuridine toxicity tests, which included studies in mice, rats, dogs, and monkeys, concluded that the available ...

TORONTO, April 15, 2014—Teenagers who have suffered a traumatic brain injury such as a concussion are at "significantly greater odds" of attempting suicide, being bullied and engaging in a variety of high risk behaviours, a new study has found. They are also more likely to become bullies themselves, to have sought counselling through a crisis help-line or to have been prescribed medication for anxiety, depression or both, said Dr. Gabriela Ilie, lead author of the study and a post-doctoral fellow at St. Michael's Hospital. They have higher odds of damaging property, breaking ...

MINNEAPOLIS / ST. PAUL (04/15/2014) — A first-of-its-kind study by researchers at the University of Minnesota found that on average nationally, people of color are exposed to 38 percent higher levels of nitrogen dioxide (NO2) outdoor air pollution compared to white people. Nitrogen dioxide comes from sources like vehicle exhaust and power plants. Breathing NO2 is linked to asthma symptoms and heart disease. The Environmental Protection Agency has listed it as one of the seven key air pollutants it monitors. The researchers studied NO2 levels in urban areas across the ...

Washington, DC — The size and shape of two brain regions involved in emotion and motivation may differ in young adults who smoke marijuana at least once a week, according to a study published April 16 in The Journal of Neuroscience. The findings suggest that recreational marijuana use may lead to previously unidentified brain changes, and highlight the importance of research aimed at understanding the long-term effects of low to moderate marijuana use on the brain. Marijuana is the most commonly used illicit drug in the United States, with an estimated 18.9 million people ...

Liken it to a case of where two genes are better than one. Scientists have found a class of genes, called small-scale duplication genes, or SSDs, that are important for adapting to novel environments and surviving environmental changes. Published in the advanced online edition of Molecular Biology and Evolution, authors Takashi Makino, Masakado Kawata, et al., were the first to examine more than 30 fully sequenced vertebrate genomes to look at SSDs as genetic signposts that correlated with habitat variability. SSDs have been generated continually during evolution, and ...

To combat disease outbreaks, public health officials often use painstaking fieldwork to try to stay one step ahead of the infectious bugs, linking patients' symptoms to a source of infection to quickly identify the common culprit in related cases. Now, a new field called genomic epidemiology is taking advantage of the rapidly reduced costs of next-generation DNA sequencing to better inform public health officials faced with ongoing outbreaks. In the advanced online edition of Molecular Biology and Evolution, authors Didelot et al. developed a versatile computational ...

WASHINGTON – In the first known study of its kind, researchers have shown that the language we learn as children affects brain structure, as does hearing status. The findings are reported in the Journal of Neuroscience. While research has shown that people who are deaf and hearing differ in brain anatomy, these studies have been limited to studies of individuals who are deaf and use American Sign Language (ASL) from birth. But 95 percent of the deaf population in America is born to hearing parents and use English or another spoken language as their first language, usually ...

All organisms, from mammals to fungi, have daily cycles controlled by a tightly regulated internal clock, called the circadian clock. The whole-body circadian clock, influenced by the exposure to light, dictates the wake-sleep cycle. At the cellular level, the clock is controlled by a complex network of genes and proteins that switch each other on and off based on cues from their environment. Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro Goriki, Toru Takumi and their colleagues from RIKEN and Hiroshima University in ...

CHICAGO --- Young adults who used marijuana only recreationally showed significant abnormalities in two key brain regions that are important in emotion and motivation, scientists report. The study was a collaboration between Northwestern Medicine® and Massachusetts General Hospital/Harvard Medical School. This is the first study to show casual use of marijuana is related to major brain changes. It showed the degree of brain abnormalities in these regions is directly related to the number of joints a person smoked per week. The more joints a person smoked, the more abnormal ...

Higher maternal body mass index (BMI) before or in early pregnancy is associated with an increased risk of fetal death, stillbirth, and infant death, with women who are severely obese having the greatest risk of these outcomes from their pregnancy, according to a study in the April 16 issue of JAMA. Worldwide, approximately 2.7 million stillbirths occurred in 2008. In addition, an estimated 3.6 million neonatal deaths (death following live birth of an infant but before age 28 days) occur each year. Several studies have suggested that greater maternal body mass index ...

An analysis that included active military personnel finds that the rate of the thyroid disorder Graves disease is more common among blacks and Asian/Pacific Islanders compared with whites, according to a study in the April 16 issue of JAMA. Donald S. A. McLeod, F.R.A.C.P., M.P.H., of the QIMR Berghofer Medical Research Institute, Queensland, Australia and colleagues studied all U.S. active duty military, ages 20 to 54 years, from January 1997 to December 2011 to determine the rate of Graves disease and Hashimoto thyroiditis (a progressive autoimmune disease of the thyroid ...

Cases of diabetes and pre-diabetes in the United States have nearly doubled since 1988, suggests new research from the Johns Hopkins Bloomberg School of Public Health, with obesity apparently to blame for the surge. The researchers also found that the burden of the disease has not hit all groups equally, with alarming increases in diabetes in blacks, Hispanics and the elderly. According to new research reported in the April 15, 2014 issue of the Annals of Internal Medicine, diabetes increased from 6 percent to 10 percent in the past two decades and pre-diabetes also doubled ...

Stanford, CA—Floods and droughts are increasingly in the news, and climate experts say their frequency will only go up in the future. As such, it is crucial for scientists to learn more about how these extreme events affect plants in order to prepare for and combat the risks to food security that could result. Like animals, plants have hormones that send chemical signals between its cells relaying information about the plant's development or interactions with the outside world. One particular way in which plants use hormone signals is in reaction to drought or soil saltiness. ...

Sarcopenia — the age-related loss of muscle mass and strength — may put up to 50 percent of seniors at greater risk for disability, yet there is no consensus within the medical community for how this condition should be measured. However, a new collection of articles appearing in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences (volume 69, number 5) lays out an empirically derived set of criteria for diagnosing sarcopenia. These recommendations are a result of the Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia ...

Stanford, CA— Photosynthesis provides fixed carbon and energy for nearly all life on Earth, yet many aspects of this fascinating process remain mysterious. For example, little is known about how it is regulated in response to changes in light intensity. More fundamentally, we do not know the full list of the parts of the molecular machines that perform photosynthesis in any organism. A type of single-cell green algae called Chlamydomonas reinhardtii is a leading subject for photosynthesis research. Despite its importance in the research world, few tools are available ...

Tucked away in Hartford, Connecticut, a Puerto Rican community is creating a tropical home away from home through cuisine that is so authentic it has caught the attention of scientists. David W. Taylor (University of Portland) and Gregory J. Anderson (University of Connecticut) took a close look at the fresh crops in the Puerto Rican markets of Hartford and uncovered evidence that gives new meaning to a phrase that food lovers have been using for years: home is in the kitchen. "Culinary preferences tell us a good deal about human culture, what is important, and what constitutes ...

Pivoting planets that lean one way and then change orientation within a short geological time period might be surprisingly habitable, according to new modeling by NASA and university scientists affiliated with the NASA Astrobiology Institute. The climate effects generated on these wobbling worlds could prevent them from turning into glacier-covered ice lockers, even if those planets are somewhat far from their stars. And with some water remaining liquid on the surface long-term, such planets could maintain favorable conditions for life. "Planets like these are far enough ...

Internal damage in fiber-reinforced composites, materials used in structures of modern airplanes and automobiles, is difficult to detect and nearly impossible to repair by conventional methods. A small, internal crack can quickly develop into irreversible damage from delamination, a process in which the layers separate. This remains one of the most significant factors limiting more widespread use of composite materials. However, fiber-composite materials can now heal autonomously through a new self-healing system, developed by researchers in the Beckman Institute's Autonomous ...

CORVALLIS, Ore. – Handling frozen fish caused nearly half of all injuries aboard commercial freezer-trawlers and about a quarter of the injuries on freezer-longliner vessels operating off the coast of Alaska, new research from Oregon State University shows. Many of those injuries and others aboard the two types of vessels could be prevented with the right interventions, and the research methods used in the study could help identify and reduce injuries and fatalities in other types of commercial fishing, said researcher Devin Lucas. His findings were published in the American ...

CHAMPAIGN, Ill. — Scientists have solved a decades-old medical mystery – and in the process have found a potentially less toxic way to fight invasive fungal infections, which kill about 1.5 million people a year. The researchers say they now understand the mechanism of action of amphotericin, an antifungal drug that has been in use for more than 50 years – even though it is nearly as toxic to human cells as it is to the microbes it attacks. A report of the new findings appears in Nature Chemical Biology. "Invasive fungal infections are a very important unmet medical ...

Miami could know as early as 2020 how high sea levels will rise into the next century, according to a team of researchers including Florida International University scientist Rene Price. Price is also affiliated with the National Science Foundation's (NSF) Florida Coastal Everglades Long-Term Ecological Research (LTER) site, one of 25 such NSF LTER sites in ecosystems from coral reefs to deserts, mountains to salt marshes around the world. Scientists conclude that sea level rise is one of the most certain consequences of climate change. But the speed and long-term ...