While humans have harnessed the power of yeast to ferment bread and beer, the function of yeast or other types of fungi that live in and on the human body is not well understood. In the first study of human fungal skin diversity, National Institutes of Health researchers sequenced the DNA of fungi at skin sites of healthy adults to define the normal populations across the skin and to provide a framework for investigating fungal skin conditions. Human skin surfaces are complex ecosystems for microorganisms, including fungi, bacteria and viruses, which are known collectively ...

PHILADELPHIA - The human gut is loaded with commensal bacteria – "good" microbes that, among other functions, help the body digest food. The gastrointestinal tract contains literally trillions of such cells, and yet the immune system seemingly turns a blind eye. However, in several chronic human diseases such as inflammatory bowel disease (IBD), HIV/AIDS, cancer, cardiovascular disease, and diabetes, the immune system attacks these normally beneficial bacteria, resulting in chronic inflammation and contributing to disease progression. Now, researchers may finally understand ...

VIDEO: EPFL scientists have revealed the mechanism, hidden deep within cell mitochondria, that is responsible for making organisms age. Nematodes treated with antibiotics designed to disrupt this mechanism lived longer and... Click here for more information. Why is it that within a homogeneous population of the same species, some individuals live three times as long as others? This question has stumped scientists for centuries. Now, EPFL researchers led by Johan Auwerx ...

Chevy Chase, MD—Widely-used fish oil supplements modestly increase amounts of a hormone that is associated with lower risk of diabetes and heart disease, according to a study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Fish oil supplements, also called omega 3 fatty acid capsules, raise levels of adiponectin in the bloodstream. Adiponectin is an important hormone that has beneficial effects on metabolic processes like glucose regulation and the modulation of inflammation. In long-term human studies, higher ...

Chevy Chase, MD—Patients with underlying heart failure are more likely to experience adverse outcomes from mild hypothyroidism, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Hypothyroidism occurs when an underactive thyroid does not produce enough hormones. More than 9.5 million people nationwide have hypothyroidism. People who have thyroid function at the low end of the normal range have subclinical hypothyroidism, also called mild hypothyroidism. "Our data suggest that mild hypothyroidism ...

Irvine, Calif. – As the world prepares for what may be the next pandemic strain of influenza virus, in the H7N9 bird flu, a new UC Irvine study reveals that the 2009 H1N1 swine flu pandemic was deadliest for people under the age of 65, while those 65 and over had greater immunity due to previous exposure to similar viruses. Deaths from flu pandemics tend to skew younger than those from seasonal flu because of "antigenic recycling," or the fact that some parts of flu viruses have already made the rounds. Between 1918 and 1957, all flu viruses in circulation fell into the ...

Radically different viruses share genes and are likely to share ancestry, according to research published in BioMed Central's open access journal Virology Journal this week. The comprehensive phylogenomic analysis compares giant viruses that infect amoeba with tiny viruses known as virophages and to several groups of transposable elements. The complex network of evolutionary relationships the authors describe suggests that viruses evolved from non-viral mobile genetic elements and vice versa, on more than one occasion. The recent discovery of virophages inside the giant ...

Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases. The exact cause of these diseases – autoimmune thyroid disease, coeliac disease, Crohn's disease, psoriasis, multiple sclerosis and type 1 diabetes– is unknown, but is believed to be a complex combination of genetic and environmental factors. In each disease only aproportion of the heritability is explained by the identifiedgenetic variants. The techniques used to date, have generally identified common ...

Swedish scientists have mapped the gene sequence of Norway spruce (the Christmas tree) – a species with huge economic and ecological importance - and that is the largest genome to have ever been mapped. The genome is complex and seven times larger than that of humans. The results have been published in the prestigious journal Nature. This major research project has been led by Umeå Plant Science Centre (UPSC) in Umeå and the Science for Life Laboratory (SciLifeLab) in Stockholm. In addition to its scientific interest this new knowledge has immense importance to the ...

Researchers at the Universities of Leeds and Chicago have uncovered an important mechanism behind the generation of astrophysical magnetic fields such as that of the Sun. Scientists have known since the 18th Century that the Sun regularly oscillates between periods of high and low solar activity in an 11-year cycle, but have been unable to fully explain how this cycle is generated. In the 'Information Age', it has become increasingly important to be able to understand the Sun's magnetic activity, as it is the changes in its magnetic field that are responsible for ...

Irvine, Calif. – Two hungry young galaxies that collided 11 billion years ago are rapidly forming a massive galaxy about 10 times the size of the Milky Way, according to UC Irvine-led research published Wednesday in the journal Nature. Capturing the creation of this type of large, short-lived star body is extremely rare – the equivalent of discovering a missing link between winged dinosaurs and early birds, said the scientists, who relied on the once-powerful Herschel space telescope and observatories around the world. The new mega-galaxy, dubbed HXMM01, "is the brightest, ...

What people take from nature – water, food, timber, inspiration, relaxation – are so abundant, it seems self-evident. Until you try to quantitatively understand how and to what extent they contribute to humans. In today's world, where competition for and degradation of natural resources increases globally, it becomes ever more crucial to quantify the value of ecosystem services – the precise term that defines nature's benefits, and even more important to link how different types of ecosystem services affect various components of human well-being. Scientists at Michigan ...

In the tropics at heights more than 10 miles above the surface, the prevailing winds alternate between strong easterlies and strong westerlies roughly every other year. This slow heartbeat in the tropical upper atmosphere, referred to as the quasibiennial oscillation (QBO), impacts the winds and chemical composition of the global atmosphere and even the climate at Earth's surface. The pulse of the QBO has weakened substantially at some altitudes over the last six decades, according to a new study by scientists at the International Pacific Research Center, University ...

Scientists from the University of Southampton have developed a device which records the brain activity of worms to help test the effects of drugs. NeuroChip is a microfluidic electrophysiological device, which can trap the microscopic worm Caenorhadbitis elegans and record the activity of discrete neural circuits in its 'brain' - a worm equivalent of the EEG. C. elegans have been enormously important in providing insight into fundamental signalling processes in the nervous system and this device opens the way for a new analysis. Prior to this development, electrophysiological ...

Harvard physicists have developed a novel technique that can detect molecular variants in chemical mixtures – greatly simplifying a process that is one of the most important, though time-consuming, processes in analytical chemistry. As described in a paper in Nature, post-doctoral researcher David Patterson, Professor of Physics John Doyle and Dr. Melanie Schnell of the Center for Free-Electron Laser Science (CFEL) in Hamburg, Germany developed a system that relies on finely-tuned microwave fields to identify molecular variants apart, and to determine how much variant ...

Dinosaurs are often thought of as large, fierce animals, but new research highlights a previously overlooked diversity of small dinosaurs. In the Journal of Vertebrate Paleontology, a team of paleontologists from the University of Toronto, Royal Ontario Museum, Cleveland Museum of Natural History and University of Calgary have described a new dinosaur, the smallest plant-eating dinosaur species known from Canada. Albertadromeus syntarsus was identified from a partial hind leg, and other skeletal elements, that indicate it was a speedy runner. Approximately 1.6 m (5 ft) ...

The discovery of potential environmental and human health effects from disposal of millions of rechargeable lithium-ion batteries each year has led scientists to recommend stronger government policies to encourage recovery, recycling and reuse of lithium-ion (Li-ion) battery materials. That's the conclusion of a new paper in the ACS journal Environmental Science & Technology. Oladele A. Ogunseitan and colleagues point out that Li-ion batteries have become mainstays for powering everything from smart phones to components in new jetliners, with global sales approaching ...

Re-routing anti-cancer drugs to the "power plants" that make energy to keep cells alive is a promising but long-neglected approach to preventing emergence of the drug-resistant forms of cancer — source of a serious medical problem, scientists are reporting. That's the conclusion of a new study published in the journal ACS Chemical Biology. Shana Kelley and colleagues explain that doxorubicin and other common forms of chemotherapy work by damaging the genes inside the nucleus of cancer cells. Cancer cells divide and multiply faster than surrounding normal cells, making ...

Children living in households where the parents are married are less likely to be obese, according to new research from Rice University and the University of Houston. "Childhood obesity is a significant public health issue in our country, with nearly one-third of all U.S. children ages 2-17 overweight or obese," said Rachel Kimbro, study co-author, associate professor of sociology at Rice and director of Rice's Kinder Institute Urban Health Program. "Despite this, very little research has been conducted to explore the impact of family structure on this epidemic." In ...

National Lung Screening Trial (NLST) investigators also conclude that the 20 percent reduction in lung cancer mortality with low-dose computed tomography (LDCT) versus chest X-ray (CXR) screening previously reported in the NLST primary paper is achievable at experienced screening centers in the United States. Philadelphia, PA—Physicians have more information to share with their patients about the benefits and risks of LDCT lung cancer screening following today's publication in the New England Journal of Medicine of the results of the first (of three planned) annual screening ...

Malaria-carrying mosquitos appear to be manipulated by the parasites they carry, but this manipulation may simply be part of the mosquitos' immune response, according to Penn State entomologists. "Normally, after a female mosquito ingests a blood meal, she matures her eggs and does not take another one until the meal is digested," said Lauren J. Cator, postdoctoral fellow in entomology and a member of the Center for Infectious Disease Dynamics, Penn State. "If infected, however, mosquitos will wait to eat until the parasites developing within the gut mature and migrate ...

URBANA - A University of Illinois researcher says that the cornerstone of our efforts to alleviate food insecurity should be to encourage more people to participate in the Supplemental Nutrition Assistance Program (SNAP) "because it works." According to Craig Gundersen, SNAP, formerly known as the Food Stamp Program, is a great social safety net program and with some additional improvements could be even more successful at reducing the number of food-insecure households. Gundersen is a U of I professor of agricultural and consumer economics and executive director of the ...

A 2012 survey of internal medicine residents at Massachusetts General Hospital (MGH) – one of the nation's leading teaching hospitals – found that more than half rated the training they had received in addiction and other substance use disorders as fair or poor. Significant numbers felt unprepared to diagnose or treat such disorders, results similar to surveys of practicing physicians. In response to the findings, recently published online in the journal Substance Abuse, the MGH has increased residents' training in addiction medicine. "Our residents estimated that one ...

WEST LAFAYETTE, Ind. – Researchers have created a new type of transparent electrode that might find uses in solar cells, flexible displays for computers and consumer electronics and future "optoelectronic" circuits for sensors and information processing. The electrode is made of silver nanowires covered with a material called graphene, an extremely thin layer of carbon. The hybrid material shows promise as a possible replacement for indium tin oxide, or ITO, used in transparent electrodes for touch-screen monitors, cell-phone displays and flat-screen televisions. Industry ...

URBANA – What effect does a father's depression have on his young son or daughter? When fathers report a high level of emotional intimacy in their marriage, their children benefit, said a University of Illinois study. "When a parent is interacting with their child, they need to be able to attend to the child's emotional state, be cued in to his developmental stage and abilities, and notice whether he is getting frustrated or needs help. Depressed parents have more difficulty doing that," said Nancy McElwain, a U of I professor of human development. But if a depressed ...