Infection during a newborn's first 7 days of life is associated with bacterial infection or colonization in the mother Early-onset neonatal infection, defined as infection in the first 7 days of life, is associated with maternal infection and colonization, a systematic review and meta-analysis by Grace Chan (Johns Hopkins School of Public Health) and colleagues found in this week's issue of PLOS Medicine. Newborns of mothers with laboratory-confirmed infection had an odds ratio of 6.6 (95%CI 3.9-11.2) for laboratory-confirmed infection themselves compared with newborns ...

Mental health conditions contribute to approximately 14% of the total global burden of disease but there is a substantial treatment gap in both developed and developing countries. Treatment of mental health conditions in low resource settings such as Nigeria, one of Africa's most populous countries, is particularly challenging where that are few mental health professionals. For example Nigeria has a population of ~150 million but only 0.06 psychiatrists and 0.02 psychologists per 100,000 people. In order to address the treatment gap the World Health Organization (WHO) ...

Research at the University of Liverpool has shown that the mechanisms of the human foot are not as unique as originally thought and have much more in common with the flexible feet of other great apes. Current understanding of the evolution of human walking is based on research from the 1930s, which proposes that human feet function very differently to those of other apes, due to the development of arches in the mid-foot region and the supposed rigidity of that on the outside edge of the foot. In a study of more than 25,000 human steps made on a pressure-sensitive treadmill ...

OAKLAND, Calif., August 20, 2013 — Kaiser Permanente Northern California nearly doubled the rate of blood pressure control among adult members with diagnosed hypertension between 2001 and 2009 through one of the largest, community-based hypertension programs in the nation, as reported today in the Journal of the American Medical Association. The rate of hypertension control throughout Kaiser Permanente Northern California increased from 43.6 in 2001 to 80.4 percent in 2009, as measured by the Healthcare Effectiveness Data and Information Set quality measurement set by ...

Implementation of a large-scale hypertension program that included evidence-based guidelines and development and sharing of performance metrics was associated with a near-doubling of hypertension control between 2001 and 2009, compared to only modest improvements in state and national control rates, according to a study in the August 21 issue of JAMA. "Hypertension affects 65 million adults in the United States (29 percent) and is a major contributor to cardiovascular disease. Although effective therapies have been available for more than 50 years, fewer than half of ...

In a large national study, higher levels of the urinary albumin-to-creatinine ratio was associated with greater risk of incident but not recurrent coronary heart disease in black individuals when compared with white individuals, according to a study in the August 21 issue of JAMA. "Increased urinary albumin excretion is an important marker of kidney injury and a strong risk factor for cardiovascular disease. Black individuals have higher levels of urinary albumin excretion than white individuals, which may contribute to racial disparities in cardiovascular outcomes," ...

Although a pooling of data from 12 studies showed a statistically significant association between use of lateral wedge insoles and lower pain in medial knee osteoarthritis, among trials comparing wedge insoles with neutral insoles, there was no significant or clinically important association between use of wedge insoles and reduction in knee pain, according to a study in the August 21 issue of JAMA. "Osteoarthritis of the knee is a common painful chronic disease whose prevalence is increasing and for which there are few efficacious treatment options. The increase in ...

Researchers have identified a new genome-wide significant locus (the place a gene occupies on a chromosome) for infantile hypertrophic pyloric stenosis (IHPS), a serious gastrointestinal condition associated with gastrointestinal obstruction, according to a study in the August 21 issue of JAMA. Characteristics of this locus also suggest the possibility of an inverse relationship between levels of circulating cholesterol in neonates and IHPS risk. "Infantile hypertrophic pyloric stenosis is the leading cause of gastrointestinal obstruction in the first months of life, ...

"Carbon monoxide (CO) poisoning is a significant U.S. health problem, responsible for approximately 500 accidental deaths annually, and a risk of 18 percent to 35 percent for cognitive brain injury 1 year after poisoning. Most morbidity and mortality from CO poisoning is believed to be preventable through public education and CO alarm use. States have been enacting legislation mandating residential CO alarm installation. However, as of December 2012, 10 of the 25 states with statutes mandating CO alarms exempted homes without fuel-burning appliances or attached garages, ...

You take your piano lesson, you go to sleep and when you wake up your fingers are better able to play that beautiful sequence of notes. How does sleep make that difference? A new study helps to explain what happens in your brain during those fateful, restful hours when motor learning takes hold. "The mechanisms of memory consolidations regarding motor memory learning were still uncertain until now," said Masako Tamaki, a postdoctoral researcher at Brown University and lead author of the study that appears Aug. 21 in the Journal of Neuroscience. "We were trying to figure ...

Stop smoking services across England have had an increasing impact in helping smokers to quit in their first 10 years of operation and have successfully reached disadvantaged groups, finds a study published on bmj.com today. However, performance across local services has varied considerably and requires attention, say the authors. In 1998, the UK government established a network of stop smoking services to ensure that every smoker in the country who wanted help with stopping would have access to evidence-based support as well as medication. Other countries have since ...

Chevy Chase, MD—Glucagon, a hormone involved in regulating appetite, loses its ability to help obese people feel full after a meal, but it continues to suppress hunger pangs in people with type 1 diabetes, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The primary role of glucagon, a hormone secreted by the pancreas, is to signal the body to release stored glucose when blood sugar falls too low. But growing evidence suggests the hormone also may play a role in controlling food intake ...

Chevy Chase, MD—Women diagnosed with gestational diabetes are nearly seven times more likely to have obstructive sleep apnea than other pregnant women, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Gestational diabetes causes glucose levels in the bloodstream to rise above normal levels. This form of diabetes occurs during pregnancy, typically in the second trimester. Between four and eight of every 100 pregnant women in the United States develop gestational diabetes. The new study ...

Maternity care that involves a midwife as the main care provider leads to better outcomes for most women, according to a systematic review published in The Cochrane Library. Researchers found that women who received continued care throughout pregnancy and birth from a small group of midwives were less likely to give birth pre-term and required fewer interventions during labour and birth than when their care was shared between different obstetricians, GPs and midwives. In many countries, including the UK and Australia, midwives act as the main providers of care for women ...

Scientists using a pioneering bio-imaging system to record simultaneously the development of hundreds of aquatic embryos have discovered significant parent-offspring similarities in the timing and sequence of that development. Researchers at Plymouth University have found the timing of key developmental milestones – such as the first beating of the heart, formation of the eyes and movement – differs markedly between individuals in a species of aquatic snail, but also that these timings appear to be heritable, i.e. they are passed from mother to offspring. The study, made ...

Frontiers in Plant Science Transgenic bacteria shed light on symbiotic exchanges within the soil Adding light-producing bacteria to soil can be a powerful method for tracking in real time how plant roots provide soil bacteria with carbohydrates, according to a new study in Frontiers in Plant Science. Soil bacteria rely for their growth on compounds released from plant roots in the form of excretions and sloughed-off cells, while bacteria often make scarce nutrients available to roots in exchange. For the first time, researchers from Woods Hole Marine Biological Laboratory ...

The concept behind gene therapy is simple: deliver a healthy gene to compensate for one that is mutated. New research published today in the Journal of Neuroscience suggests this approach may eventually be a feasible option to treat Rett Syndrome, the most disabling of the autism spectrum disorders. Gail Mandel, Ph.D., a Howard Hughes Investigator at Oregon Health and Sciences University, led the study. The Rett Syndrome Research Trust, with generous support from the Rett Syndrome Research Trust UK and Rett Syndrome Research & Treatment Foundation, funded this work through ...

Like cuckoos, honeyguides are parasitic birds that lay their eggs in other birds' nests and dupe them into raising their young. Now scientists reveal that, unlike in cuckoos, the resemblance between honeyguide eggs and those of their bee-eater bird hosts hasn't evolved to trick hosts into accepting the imposter egg as one of their own. Rather, it appears to have evolved to trick other honeyguides who would otherwise destroy the eggs because of fierce competition for host nests. The new research is published today, 21 August, in the journal Biology Letters. Honeyguides ...

SAN ANTONIO (Aug. 20, 2013) — Scientists today reported a possible basis for why food-restricted animals show increased susceptibility to drugs of abuse. This association has puzzled researchers since it was first observed more than three decades ago. Senior author Michael Beckstead, Ph.D., from the School of Medicine at The University of Texas Health Science Center San Antonio, said the team found that dopamine neurons in a brain region called the substantia nigra fire bursts more than twice as frequently in chronically food-restricted mice. Cocaine significantly enhanced ...

People usually feel good when they make a charitable donation, but they feel even better if they make the donation directly to someone they know or in a way that builds social connection. Research to be published in the International Journal of Happiness and Development investigates for the first time how social connection helps turn generous behavior into positive feelings on the part of the donor. Lara Aknin of Simon Fraser University, in Burnaby, British Columbia, Canada, and colleagues at the University of British Columbia, Vancouver and Harvard Business School, Massachusetts, ...

One of the most promising types of solar cells has a few drawbacks. A scientist at Michigan Technological University may have overcome one of them. Dye-sensitized solar cells are thin, flexible, easy to make and very good at turning sunshine into electricity. However, a key ingredient is one of the most expensive metals on the planet: platinum. While only small amounts are needed, at $1,500 an ounce, the cost of the silvery metal is still significant. Yun Hang Hu, the Charles and Caroll McArthur Professor of Materials Science and Engineering, has developed a new, inexpensive ...

MIAMI – August 20, 2013 -- A new computer simulation conducted at the University of Bristol (UB) and University of Miami (UM) Rosenstiel School of Marine & Atmospheric Science has revealed the epic, ocean-spanning journeys travelled by millimetre-sized coral larvae through the world's seas. The study, published in Global Ecology and Biogeography, is the first to recreate the oceanic paths along which corals disperse globally, and will eventually aid predictions of how coral reef distributions may shift with climate change. Coral reefs are under increasing threat ...

Genetics may play a role in how people's taste receptors send signals, leading to a wide spectrum of taste preferences, according to Penn State food scientists. These varied, genetically influenced responses may mean that food and drink companies will need a range of artificial sweeteners to accommodate different consumer tastes. "Genetic differences lead to differences in how people respond to tastes of foods," said John Hayes, assistant professor, food science and director of the sensory evaluation center. Based on the participants' genetic profile, researchers were ...

A recent study by members of the Children's Oncology Group reports results of a large trial showing that children whose leukemia cells have amplification of a portion of chromosome 21 may require more aggressive treatment for Acute Lymphoblastic Leukemia (ALL) than children without this gene amplification. "This helps identify patients who need more therapy than they may otherwise get," says Stephen Hunger, MD, investigator at the University of Colorado Cancer Center, professor of pediatrics at the University of Colorado School of Medicine, and director of the Center ...

Flight safety experts studying recent high-profile plane crashes found sudden autopilot disconnection to be a design flaw that creates unnecessary emergencies by surprising pilots during critical, high-workload episodes. "The sudden disengagement of autopilot is analogous to a pilot suddenly throwing up his or her hands and blurting to the copilot, 'Your Plane!'" says Eric E. Geiselman, lead author of a recently published two-article Ergonomics in Design series, "Flight Deck Automation: Invaluable Collaborator or Insidious Enabler" (July issue) and "A Call for Context-Aware ...