HOUSTON –HER2 and its epidermal growth factor receptor cousins mobilize a specialized protein to activate a major player in cancer development and sugar metabolism, scientists report in the May 25 issue of Cell. This chain of events, the scientists found, promotes Herceptin resistance in breast cancer and activation of glucose metabolism (glycolysis), which cancer cells primarily rely on to fuel their growth and survive. Their research focused on Skp2 E3 ligase, a protein that binds to and tags other proteins with molecules called ubiquitins, in this case to activate ...

The current economic climate has resulted in many a stressful home life. A trend in domestic cases is always an unfortunate byproduct of a tough economic situation. Consumers are seeking private investigators who are thrifty and who are using technology to help stretch a buck. EasyTracGPS now introduces the ComTrac "Covert Pro" GPS tracking device to investigators worldwide...to assist in maximizing client retainers and to improve surveillance results. A wireless magnetic vehicle tracking device, the ComTrac "Covert Pro" offers live 10 second position ...

Cold Spring Harbor, N.Y. – In a study published in the journal Cell on May 24, Cold Spring Harbor Laboratory (CSHL) scientists describe the three-dimensional atomic structure of a human protein bound to a piece of RNA that "guides" the protein's ability to silence genes. The protein, Argonaute-2, is a key player in RNA interference (RNAi), a powerful cellular phenomenon that has important roles in diverse biological processes, including an organism's development. "Detailed knowledge of the structure of human Argonaute-2 and the way it interacts with its RNA guides will ...

"We are honored to have been selected to auction this home," said John Nicholls, president of the company. "This property would make a great primary residence or investment property." "The property at auction consists of a 3 bedroom 2 bath ranch home on a 1.23 acre lot," said Mr. Kelly Strauss, Nicholls Auction Marketing Group Coordinator." Highlights include a detached garage/workshop, large fenced back yard and county water. Be at the auction and buy at the PRICE YOU BID!!" said Strauss. "The property is centrally located ...

Having already presented itself to the European and South African markets, the Panic Room Company enjoyed its first foray into Latin America this month at the EXPOSEC International Security Fair in Sao Paolo, Brazil - the world's fifth largest security show. Teaming up with Sao Paolo-based security solutions experts, Grasp, the Panic Room Company was demonstrated to a wide range of potential customers and distributors throughout the three day show and interest was once again considerable. Grasp's owner, Denis Frate, had this to say, "The Panic Room Company ...

MADISON -- Eons ago, nature solved the problem of converting solar energy to fuels by inventing the process of photosynthesis. Plants convert sunlight to chemical energy in the form of biomass, while releasing oxygen as an environmentally benign byproduct. Devising a similar process by which solar energy could be captured and stored for use in vehicles or at night is a major focus of modern solar energy research. "It is widely recognized that solar energy is the most abundant source of energy on the planet," explains University of Wisconsin-Madison chemistry professor ...

Featuring a comprehensive index of the Federal Rules of Bankruptcy Procedure, Federal Bankruptcy Rules 2012 is an excellent resource for both attorneys and non-attorneys dealing with federal bankruptcy. Included with this new edition by Summit Legal Publishing is free online access to official bankruptcy forms and procedural forms, instructions and committee notes. Local forms and procedural guides for the Bankruptcy Appellate Panels are available online as well. All of these forms are presented as downloadable, printable, full-sized versions. Federal Bankruptcy Rules ...

(SACRAMENTO, Calif.) — UC Davis researchers have found that workers' compensation insurance is not used nearly as much as it should be to cover the nation's multi-billion dollar price tag for workplace illnesses and injuries. Instead, almost 80 percent of these costs are paid by employer-provided health insurance, Medicare, Medicaid, Social Security and other disability funds, employees and other payers. Authors of the study, published in the April issue of the Journal of Occupational and Environmental Medicine, said this cost shifting leads to artificially low workers' ...

Employee attendance and vacation tracking should not be an administrative nightmare for HR managers and business owners. Halfpricesoft.com recently updated ezTimeSheet time tracking software with new vacation and leave plan options to give small businesses more versatility when tracking vacation time, sick time and paid time off for employees. "Employee attendance tracking is important for any business and organization; however employee attendance and vacation time tracking can be very time-consuming," explains Dr. Ge, President and Founder of halfpricesoft.com. ...

COLUMBIA, Mo. — For 5,000 years, the Chinese have used a system of medicine based on the flow and balance of positive and negative energies in the body. In this system, the appearance of the tongue is one of the measures used to classify the overall physical status of the body, or zheng. Now, University of Missouri researchers have developed computer software that combines the ancient practices and modern medicine by providing an automated system for analyzing images of the tongue. "Knowing your zheng classification can serve as a pre-screening tool and help with preventive ...

Scientists believe they've pinpointed the last crucial piece of the 80-year-old puzzle of how plants "know" when to flower. Determining the proper time to flower, important if a plant is to reproduce successfully, involves a sequence of molecular events, a plant's circadian clock and sunlight. Understanding how flowering works in the simple plant used in this study – Arabidopsis – should lead to a better understanding of how the same genes work in more complex plants grown as crops such as rice, wheat and barley, according to Takato Imaizumi, a University of Washington ...

The Trabasack team will be returning to the Mobility Roadshow 2012 after three years of steady progress and hard work and their return won't be without a bang, in the form of a brand new product launch exclusive to the roadshow. For their second appearance at the Peterborough based event, Trabasack and their full product range will be joined by a brand new Media Mount, which has already been attracting lots of interest and is an innovative accessory for the products already available from the Leicestershire based company. Media Mount Launch http://www.trabasack.co.uk/Media-mount-launched The ...

Famous online pet boutique, Rockstar Puppy, recently announced it has added new releases of motorcycle dog carriers to its line of designer dog clothes and whimsical accessories. Known as the online source for a personalized dog bandana or cute dog ID tags, Rockstar Puppy has continued to expand its collection with designer dog accessories exclusively designed for motorcycles. "Our extensive collection of dog carriers fit most motorcycle models," said Jessica Auria, owner of Rockstar Puppy. "Several styles are available to compliment the personal tastes ...

DeVere Carden Park, a luxurious country Hotel, Golf Resort and Spa in Cheshire saw Global Provider PerDM host their Annual Golf Tournament last weekend. The popular venue was voted Best 2011 North of England Golf Resort in Today's Golfer Travel Awards. Carden Park was chosen by PerDM as they have used the venue for many conferences and events in the past. "It is a beautiful location in Cheshire and Carden Park has always been wonderful hosts to us in the past so it was an ideal place for us to hold the Golf Tournament," says Ian Attwood, Director at PerDM. PerDM ...

Recent recommendations from the U.S. Preventive Services Task Force (USPSTF) advising elimination of routine prostate-specific antigen (PSA) screening for prostate cancer in healthy men are likely to encounter serious pushback from primary care physicians, according to results of a survey by Johns Hopkins investigators. In a survey of 125 primary care doctors, the researchers found that while doctors agreed with older recommendations to curtail routine screening in men over age 75 and among those not expected to live 10 or more years, a large number said they faced significant ...

As part of his commitment to staying current in modern advances and technology associated with sleep apnea effects and treatments, Dr. Joe Serra has attended the new obstructive sleep apnea course offered by LVI Global entitled, LVI Sleep - The Physiologic Approach to Treating OSA. The course is designed to assist dentists, such as Dr. Serra, in learning about the relationships between health, sleep breathing disorders and neuromuscular dentistry. The course teaches dentists to better identify, co-manage and refer patients who are suffering from obstructive sleep apnea ...

The transfusion of red blood cells (RBC) is a critical component in the treatment of a number of acute and chronic medical problems. Indeed, approximately 75 million units of whole blood (~34 million liters) are annually collected worldwide for processing and eventual transfusion. Despite this massive collection effort, the need for blood constantly exceeds availability due to a combination of collection, manufacturing, storage and biological (i.e., immunological) issues. The immunological issues can often be the most clinically vexing as the RBC has ~300 blood group antigens ...

David Perecman and New York construction accident lawyers at The Perecman Firm scored a major victory for an injured construction worker. As importantly, they also advanced the law regarding construction worker protection in their appeal of the Stallone v. Plaza Construction Corp. case (Index No. 105940/08). The Appellate Division, First Department ruled that the plaintiff should have summary judgment on liability under New York Labor Law 240. "We are extremely pleased with the court's decision. Protecting the safety of construction workers on the work site ...

Graphene, a stable two-dimensional structure, has attracted tremendous worldwide attention in recent years because of its unique electronic, physical and mechanical properties as well as its wide range of applications. It has been proven experimentally that the electrical properties of graphene are strongly related to its size, geometry, and edge structure. Therefore, controlling graphene to desired edge structures and shapes is required for its practical application. To date, researchers have explored many graphene patterning methods, such as a catalytic cutting [1-4], ...

The Federal Motor Carrier Safety Association (FMCSA) is planning to implement requirements that will require commercial driver's license (CDL) holders with a body mass index of at least 35 to be tested for sleep apnea. This number is based on a recent recommendation from the Medical Review Board. Drivers with a BMI of 35 or greater will be required to undergo an initial sleep apnea screening. Sleep apnea is a condition where an upper airway narrows or closes during sleep, causing sleeping patterns to be disturbed. Those with sleep apnea tend to be extra sleepy during ...

Based on information compiled by the National Highway Transportation Safety Administration (NHTSA), the American Motorists Association (AMA), and Mothers Against Drunk Driving (MADD), New York has ranked 29th for the worst drivers in the nation. Separately, these organizations already track which states have the most driver fatalities, the most tickets issued, and the most drunk drivers. Recently, the three organizations combined their efforts to demonstrate which states have the worst drivers. Data for each state was translated into a ranking in each of the following ...

Scientists have created and imaged the smallest possible five-ringed structure – about 100,000 times thinner than a human hair – and you'll probably recognise its shape. A collaboration between the Royal Society of Chemistry (RSC), the University of Warwick and IBM Research – Zurich has allowed the scientists to bring a single molecule to life in a picture, using a combination of clever synthetic chemistry and state-of-the-art imaging techniques. The scientists decided to make and visualise olympicene whose five-ringed structure was entered on ChemSpider, the RSC's ...

EAST LANSING, Mich. — An international research team has manufactured a new protein that can combat deadly flu epidemics. The paper, featured on the cover of the current issue of Nature Biotechnology, demonstrates ways to use manufactured genes as antivirals, which disable key functions of the flu virus, said Tim Whitehead, assistant professor of chemical engineering and materials science at Michigan State University. "Our most potent design has proven effective on the vulnerable sites on many pandemic influenza viruses, including several H1N1 (Spanish flu, Swine flu) ...

Hampton Inn Atlanta-Southlake Morrow GA Hotel offers close lodging to family and friends attending upcoming Atlanta Area Suzuki Piano Association (AASPA) Graduation Concerts at Clayton State University's Spivey Hall. The concerts are open to the public and will take place at 1pm and 4pm on June 3, 2012. The graduation program is designed to recognize the accomplishments of dedicated Suzuki students and teachers throughout Georgia. Marking its 15th year at Spivey Hall, the AASPA graduation concerts promote the education principles set forth by Dr. Suzuki and Dr. Kataoka. ...

The Hilton Garden Inn Hotel in Columbia SC (Northeast) offers convenient accommodations to parents and guests attending upcoming U.S. Army's Basic Combat Training (BCT) Gradation at Fort Jackson on May 31, 2012. The ceremony will take place on Hilton Field at 9:00am. Guests can also attend "Family Day" on May, 30, which allows the family and friends of graduating Soldiers to meet the battalion commander. They can also meet the unit's drill sergeants and observe demonstrations of Soldier skills. "We are pleased to welcome guests staying at our hotel near ...