Laminin, long thought to be only a structural support protein in the microenvironment of breast and other epithelial tissues, is "famous" for its cross-like shape. However, laminin is far more than just a support player with a "pretty face." Two studies led by one of the world's foremost breast cancer scientists have shown how laminin plays a central role in the development of breast cancer, the second most common cancer and second leading cause of cancer death among women in the United States. In one study it was shown how laminin influences the genetic information ...

INDIANAPOLIS – A review of 35 years of scientific medical studies confirms that the social and emotional context of the doctor–patient relationship have yet to be incorporated into the equation when it comes to health care. In spite of its strong endorsement over a decade ago by the influential Institute of Medicine report, "Crossing the Quality Chasm: A New Health System for the 21st Century," which highlighted the benefits of care that is respectful of and responsive to patients' needs, values and concerns, patient-centered medicine has not become part of the mainstream. ...

Research continues to show that the controversial abortion drug mifepristone might have another use, as a therapeutic option besides hysterectomy for women who suffer from severe symptoms associated with uterine fibroids. The University of Rochester Medical Center in 2004 began investigating mifepristone, in a class of drugs known as progesterone receptor modulators (PRMs), to treat fibroids, which affect roughly half of all women younger than 50. Results showed the drug shrank the fibroids and greatly improved the quality of life for the women involved in the clinical ...

LA JOLLA, CA, AND JUPITER, FL – March 7, 2011 – Embargoed by the journal PNAS until March 7, 2011, 3 PM, Eastern time –Working as part of a public program to screen compounds to find potential medicines and other biologically useful molecules, scientists from The Scripps Research Institute and Massachusetts Institute of Technology (MIT) have discovered an extremely potent class of potential anti-cancer and anti-neurodegenerative disorder compounds. The scientists hope their findings will one day lead to new therapies for cancer and Alzheimer's disease patients. The research—scheduled ...

Tampa, Fla. (Mar. 07, 2011) – Transplanting stem cells derived from umbilical cord blood cells and menstrual blood cells may offer future therapeutic benefit for those suffering from stroke, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS), says a team of neuroscience researchers from the University of South Florida's Department of Neurosurgery and Brain Repair and collaborators from three private-sector research groups, Saneron CCEL Therapeutics, Inc., Tampa, FL, Cryo-Cell International, Inc., Oldsmar, FL, and Cryopraxis, Cell Praxis, BioRio, Rio de Janeiro, ...

Producers and feed companies add fat to swine diets to increase energy, but recent research from the University of Illinois suggests that measurements currently used for fat digestibility need to be updated. "It's critical that we gain a better understanding of the energy value of fat," said Hans H. Stein, U of I professor in the Department of Animal Sciences. "If we don't know the true energy value of fat, we can't determine if it's economical to add to the diet." In a recent experiment, Stein and his team of researchers studied how different types of diets affect ...

An important discovery in mice may make a big difference in people's waistlines thanks to a team of Harvard scientists who found that reducing the function of a transmembrane protein, called Klotho, in obese mice with high blood sugar levels produced lean mice with reduced blood sugar levels. This protein also exists in humans, suggesting that selectively targeting Klotho could lead to a new class of drugs to reduce obesity and possibly Type 2 diabetes for people. This finding was recently published online in The FASEB Journal (http://www.fasebj.org). "Our study is a ...

This release is available in German. Carbon nanotubes have a multitude of unusual properties which make them promising candidates for optoelectronic components. However, so far it has proven extremely difficult to analyze or influence their optic and electronic properties. A team of researchers headed by Professor Alexander Holleitner, a physicist at the Technische Universitaet Muenchen and member of the Cluster of Excellence Nanosystems Munich (NIM), has now succeeded in developing a measurement method allowing a time-based resolution of the so-called photocurrent ...

Scientists have blocked harmful immune cells from entering the brain in mice with a condition similar to multiple sclerosis (MS). According to researchers from Washington University School of Medicine in St. Louis, this is important because MS is believed to be caused by misdirected immune cells that enter the brain and damage myelin, an insulating material on the branches of neurons that conduct nerve impulses. New insights into how the brain regulates immune cell entry made the accomplishment possible. Washington University scientists had borrowed an anti-cancer drug ...

GAINESVILLE, Fla. --- A University of Florida study demonstrates extinction's ripple effect through the animal kingdom, including how the demise of large mammals 20,000 years ago led to the disappearance of one species of cowbird. The study shows the trickle-down effect the loss of large mammals has on other species, and researchers say it is a lesson from the past that should be remembered when making conservation, game and land-use decisions today. "There's nothing worse for a terrestrial ecosystem than the loss of large mammals – and the loss of apex predators like ...

Columbia, MO -- It's a corn plant only a geneticist could love, but an MU researcher has found a way to help scientists love it. Instead of the characteristic fan-like tassel that waves majestically atop the stalk, this corn plant sends up a cartoonishly skinny stick. Its ears -- if it makes them at all -- resemble small, chubby, lime-green caterpillars, not exactly something you want to dig your teeth into. To top it off, the corn plant stands only about three feet tall, at full maturity, and has few leaves. "A farmer would say this corn plant looks terrible," said ...

If you can't stop the beta-amyloid protein plaques from forming in Alzheimer's disease patients, then maybe you can help the body rid itself of them instead. At least that's what scientists from New York were hoping for when they found a drug candidate to do just that. Their work appears in a research report online in The FASEB Journal (http://www.fasebj.org), and shows that a new compound, called "SMER28" stimulated autophagy in rat and mice cells. Autophagy is a process cells use to "clean out" the debris from their interior, including unwanted materials such as the protein ...

GALVESTON, Texas — Researchers have identified a critical part of the process by which one of the world's most common and dangerous early childhood infections, respiratory syncytial virus, causes disease. The discovery could lead to badly needed new therapies for RSV, which in 2005 was estimated to have caused at least 3.4 million hospitalizations and 199,000 deaths among children under five worldwide. By analyzing samples taken from infected infants and data from laboratory-mouse experiments, University of Texas Medical Branch at Galveston scientists determined that ...

Troy, N.Y. – Steel walls are no match for Tristan Lawry. The doctoral student at Rensselaer Polytechnic Institute has developed and demonstrated an innovative new system that uses ultrasound to simultaneously transmit large quantities of data and power wirelessly through thick metal walls, like the hulls of ships and submarines. Lawry, a student in the Department of Electrical, Computer, and Systems Engineering at Rensselaer, is one of three finalists for the 2011 $30,000 Lemelson-MIT Rensselaer Student Prize. A public ceremony announcing this year's winner will be held ...

For the past few years, one of the most common questions facing the Texas Water Development Board (TWDB) hasn't been over contentious water rights or proposed water projects; it's been from homeowners wanting to know what type of roofing material is most suitable for collecting rainwater for indoor domestic use. "Rainwater harvesting is becoming fairly widespread, at least in Central Texas. There's interest born out of necessity because people are simply running out of water in rural areas or they're interested in conserving water supplies and it's good for the environment," ...

Boston, Ma – Fainting, or syncope, is quite common. About 50% of people will experience fainting at some point during their lifetime. The most common type of fainting is vasovagal syncope (VVS) that is caused by a sudden drop in blood pressure resulting in reduced blood flow to the brain. VVS can occur in healthy people due to inappropriate cardiovascular responses to certain behavioral or emotional triggers such as fear, needle prick or even standing up. VVS has a daily pattern with more occurrences during the morning. This daily pattern is possibly due to the daily distribution ...

AURORA, Colo. (March 7, 2011) - A discovery at University of Colorado Cancer Center shows testing lung cancer on a molecular level can produce new insights into this deadly disease. Cancer Center member D. Ross Camidge, MD, PhD, director of the thoracic oncology clinical program at University of Colorado Hospital (UCH), turned a chance clinical observation into a new field of discovery in lung cancer. In October 2010, Camidge and colleagues published a study in the New England Journal of Medicine showing more than half of patients with a specific kind of lung cancer ...

New research reveals vast tracts of wetlands along the upper Gulf Coast are more hydrologically connected to Galveston Bay and other waters of the U.S. than previously thought, suggesting immediate implications for how they are preserved, managed and regulated, according to Texas AgriLife scientists. "Loss of wetlands closer to traditional navigable waters must be mitigated under the Clean Water Act by creating new wetlands, or preferably by protecting and restoring similar existing wetlands," said Dr. John Jacob, Texas AgriLife Extension Service environmental quality ...

A hurricane-like superstorm expected to hit California once every 200 years would cause devastation to the state's businesses unheard of even in the Great Recession, a USC economist warns. Researchers estimate the total property damage and business interruption costs of the massive rainstorm would be nearly $1 trillion. USC research professor Adam Rose calculated that the lost production of goods and services alone would be $627 billion of the total over five years. Rose, a professor with the USC School of Policy, Planning, and Development, also is the coordinator for ...

HOUSTON-(March 7, 2011)- Children without previous iron deficiencies or anemia who remained infected with Helicobacter pylori (H. pylori) had significantly lower levels of iron compared to children who had the infection eradicated, according to researchers at The University of Texas Health Science Center at Houston (UTHealth). "Half of the world's population is infected with H. pylori and most of the individuals are asymptomatically infected, according to several surveys," said Victor Cardenas, M.D., Ph.D., lead investigator of the study and associate professor of epidemiology ...

Durham, NC —For the vast majority of plants and animals, the 'bigger is better' view of evolution may not be far off the mark, says a new broad-scale study of natural selection. Organisms with bigger bodies or faster growth rates tend to live longer, mate more and produce more offspring, whether they are deer or damselflies, the authors report. Researchers working at the National Evolutionary Synthesis Center compiled and reviewed nearly 150 published estimates of natural selection, representing more than 100 species of birds, lizards, snakes, insects and plants. The ...

People are more comfortable committing sins of omission than commission—letting bad things happen rather than actively causing something bad. A new study published in Psychological Science, a journal of the Association for Psychological Science, suggests that this is because they know other people will think worse of them if they do something bad than if they let something bad happen. "Omissions and commissions come up relatively frequently in everyday life, and we sometimes puzzle over them," says moral psychologist Peter DeScioli of Brandeis University, who conducted ...

A new study published in The Journal of Sexual Medicine reveals that, for the first time, 5a-reductase inhibitors commonly used to treat urinary problems in patients with benign prostatic hyperplasia (BPH) and found in popular medications to treat hair loss, can produce, persistent erectile dysfunction (ED), depression and loss of libido, even after the medication has been discontinued. Researchers led by Abdulmaged M. Traish, MBA, PhD, of Boston University School of Medicine, examined data reported in various clinical studies from the available literature concerning ...

CHAMPAIGN, Ill. — Cardiologists may soon be able to place sensitive electronics inside their patients' hearts with minimal invasiveness, enabling more sophisticated and efficient diagnosis and treatment of arrhythmias. A team of materials scientists, mechanical and electrical engineers, and physicians has successfully integrated stretchable electronics technology with standard endocardial balloon catheters. Led by John A. Rogers, the Lee J. Flory-Founder Chair in Engineering at Illinois, the team published its work in the March 6 online edition of Nature Materials. The ...

MADISON — Years of research show black patients getting less treatment in the American health care system than their white counterparts, but a new study suggests that a quick dose of empathy helps close racial gaps in pain treatment. College students and nurses went to greater lengths to ease the pain of members of their own race in a study led by Brian Drwecki, a psychology graduate student at the University of Wisconsin-Madison. "I want to be very clear about this: We're not saying health care professionals are racist," Drwecki says. "This is not racism. Racism is ...