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Quick to laugh or smile? It may be in your genes

Researchers say common genetic variant may be associated with positive expressions


2015-06-01
(Press-News.org) EVANSTON, Ill. --- Why do some people immediately burst into laughter after a humorous moment, while others can barely crack a smile? New research examining emotional reactivity suggests one of the answers may lie in a person's DNA.

In a new study linking a gene to positive emotional expressions such as smiling and laughing, researchers demonstrated that people with a certain genetic variant -- those with short alleles of the gene 5-HTTLPR -- smiled or laughed more while watching cartoons or subtly amusing film clips than people with long alleles.

Previous research has linked the gene to negative emotions; the study provides the strongest evidence to date that the same gene is also linked to positive emotional expressions.

The research will be published online June 1 in the American Psychological Association journal Emotion.

Claudia M. Haase of Northwestern University and Ursula Beermann of the University of Geneva co-authored the study, which was conducted in the laboratories of Dacher Keltner and Robert W. Levenson at the University of California, Berkeley.

In the study, the scientists looked at short and long alleles of the gene 5-HTTLPR, which is involved in the regulation of serotonin, a neurotransmitter implicated in depression and anxiety.

An allele is a variant of a gene. Each gene has two alleles; humans inherit one allele from mom and one from dad.

Early research suggested that the short alleles predicted unwanted or negative outcomes, such as depression, anxiety and substance abuse. People with short alleles were found to have higher negative emotions than those with long alleles.

But the latest study adds to the growing body of evidence suggesting that people with short alleles also may be more sensitive to the emotional highs of life.

"Having the short allele is not bad or risky," said Haase, an assistant professor in the Human Development and Social Policy program at Northwestern's School of Education and Social Policy. "Instead, the short allele amplifies emotional reactions to both good and bad environments."

"Our study provides a more complete picture of the emotional life of people with the short allele," Haase added. "People with short alleles may flourish in a positive environment and suffer in a negative one, while people with long alleles are less sensitive to environmental conditions."

"The fundamental truth of genes is that they don't have the final say," said senior author Levenson, a leading researcher in human emotions and professor in the department of psychology at UC-Berkeley. "There's always an interaction between nature and nurture that shapes outcomes, and this study is another example of that."

The latest study combined three experiments from different Berkeley labs. In the first experiment, young adults were shown cartoons from "The Far Side" by Gary Larson and The New Yorker. In the second experiment, young, middle-aged and older adults watched a subtly amusing clip from the film "Strangers in Paradise." The final experiment asked middle-aged and older spouses to discuss an area of disagreement in their marriage.

The scientists videotaped the volunteers during the experiments. Trained researchers then coded smiling and laughter using the "Facial Action Coding System," which describes small movements in the face, said Beermann, a postdoctoral researcher at the Swiss Center for Affective Sciences at University of Geneva.

The study focused on genuine or 'real' positive emotional expressions. People sometimes smile or laugh -- even if they don't find something funny -- simply to be polite or to hide negative feelings, Beermann said. "So when you measure smiling and laughing, you want to be able to distinguish real laughs and smiles from the ones that aren't," she said.

The important clues lie in the muscle around the eyes that produce the so-called 'crow's feet,'" Beermann said. "Those can only be seen in real smiles and laughs," she said.

Overall, 336 participants were included in the final analysis. The researchers collected saliva samples from the volunteers to analyze the 5-HTTLPR gene.

The data from the three experiments combined indicated that people with the short allele of 5-HTTLPR showed greater positive emotional expressions. Specifically, people with the short allele displayed greater genuine smiling and laughing than people with the long allele.

"This study provides a dollop of support for the idea that positive emotions are under the same tent as negative ones, when it comes to the short allele," Levenson said. "It may be that across the whole palate of human emotions, these genes turn up the gain of the amplifier. It sheds new light on an important piece of the genetic puzzle."

INFORMATION:

In addition to Haase, Beermann and Levenson, other authors of the paper include Laura Saslow, Osher Center for Integrative Medicine, University of California, San Francisco; Michelle Shiota, department of psychology, Arizona State University; Sarina Saturn, department of psychology, Oregon State University; Patrick Whalen, private practice, Palo Alto; and Sandy Lwi, James Casey, Nguyen K. Nguyen and Dacher Kelter of the department of psychology and the Institute for Personality and Social Research at UC-Berkeley.


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[Press-News.org] Quick to laugh or smile? It may be in your genes
Researchers say common genetic variant may be associated with positive expressions
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