Contact Information:

Media Contact

Robert Miranda
bob@cognizantcommunication.com



Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Cells from human umbilical cord blood improve cognition in Alzheimer's disease model mice

Pretreated monocytes play a role in amyloid-β clearance, and may help confer positive effects for Alzheimer's disease sufferers


2015-09-09
(Press-News.org) Putnam Valley, NY. (Sept. 9, 2015) - Alzheimer's disease (AD), which affects an estimated 26 million people worldwide, is the fourth leading cause of death among the elderly and the leading cause of dementia. Predictions are that the number of AD cases will quadruple by 2050.

Although pharmacological methods for treating AD have been discovered, none significantly delay the progression of the disease. However, cell transplantation research using animals modeled with AD has indicated that human umbilical cord blood cells (HUCBCs) can ameliorate some cognitive deficits and reduce the effects of the amyloid-beta (Aβ) plaques, one of the physiological hallmarks of AD, comprised of peptides of 36-43 amino acids. However, the role that HUCBCs play in Aβ clearance has yet to be elucidated.

Monocytes are peripheral blood mononuclear cells (MNCs) with round nuclei that are critical components in the immune system for fighting infection and processing foreign material. A team of American, Chinese, and Japanese researchers hypothesized that monocytes derived from cord blood can help clear aggregated Aβ protein when transplanted into laboratory animals modeled with AD.

The study, using mice modeled with AD, will be published in a future issue of Cell Transplantation and is currently freely available on-line as an unedited, early e-pub at: http://ingentaconnect.com/content/cog/ct/pre-prints/content-CT-1466_Darlington_et_al

"We previously reported that HUCBCs modulated inflammation, diminished Aβ pathology, and reduced behavioral deficits in mice modeled with AD," said study corresponding author Dr. Donna Darlington of the Rashid Laboratory for Developmental Neurobiology at the Silver Child Development Center, University of South Florida. "In this study, we attempted to determine which MNC population was conferring these effects and to determine the mechanism by which these effects occur."

Over a period of two to four months, the researchers treated AD modeled mice with HUCBC-derived monocytes followed by behavioral evaluation and biochemical and histological analyses.

The researchers found that administration of HUCBC-derived monocytes not only diminished Aβ pathology in the test mice, but also improved hippocampal-dependent learning, memory, and motor function.

"MNCs may exert a therapeutic effect through phagocytosis of dead cells and cellular debris. We believe that phagocytosis (a process by which cells internalize solid particles) is a possible mechanism by which MNCs mediate Aβ clearance," said the researchers. "Most importantly, we found that aged monocytes were less effective against Aβ and that soluble amyloid precursor protein (sAPPa) could restore the phagocytic capabilities of these endogenous aged cells."

"This study contributes insight into the possible mechanisms by which monocytes exert therapeutic effects," said Dr. Shinn-Zong Lin, Vice Superintendent for the Center of Neuropsychiatry, Professor of Neurosurgery at China Medical University Hospital, and Co Editor-in-Chief for Cell Transplantation. "Future studies should weigh the benefits of using MNCs in cell therapy versus the possible detrimental effects, such as secretion of neurotoxic, inflammatory factors. The effectiveness of using MNCs in human AD patients should also be validated, as it has been a matter of conjecture."

INFORMATION:

Contact: Dr. Donna Darlington, Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, 3515 E. Fletcher Ave. Tampa, FL, USA 33613-4704
Email: ddarling@health.usf.edu
Ph: (813) 974-5975
Fax: (813) 974-1130 Citation: Darlington, D.; Li, S.; Hou, H.; Habib, A.; Tian, J.; Gao, Y.; Ehrhart, J.; Sanberg, P.R.; Sawmiller, D.; Giunta, B.; Mori, T.; Tan, J. Human umbilical cord blood-derived monocytes improve cognitive deficits and reduce β-amyloid pathology in PSAPP mice. Cell Transplant. Appeared or available on-line: July 30, 2015

The Coeditors-in-chief for CELL TRANSPLANTATION are at the Diabetes Research Institute, University of Miami Miller School of Medicine and Center for Neuropsychiatry, China Medical University Hospital, TaiChung, Taiwan. Contact, Camillo Ricordi, MD at ricordi@miami.edu or Shinn-Zong Lin, MD, PhD at shinnzong@yahoo.com.tw or David Eve, PhD or Samantha Portis, MS, at celltransplantation@gmail.com News release by Florida Science Communications http://www.sciencescribe.net


ELSE PRESS RELEASES FROM THIS DATE:

The Industrial Revolution put an end to 1,800 years of ocean cooling

2015-09-09
The high frequency and magnitude of volcanic eruptions could have been the cause of the progressive cooling of ocean surfaces over a period of 1,800 years. This is made apparent in an international study published recently in the journal Nature Geoscience, involving researcher P. Graham Mortyn of the Institute for Environmental Science and Technology (ICTA-UAB) and the UAB Department of Geography. The study emphasises that this trend came to an end with the beginning of the Industrial Revolution and the resulting global warming caused by human activity. It further shows ...

Tree planting can harm ecosystems

2015-09-09
The world's grassy biomes are key contributors to biodiversity and ecosystem services, and are under immense pressure from conversion to agriculture and tree planting, report Joseph W. Veldman, of Iowa State University, and his colleagues in an article for the October issue of BioScience. The authors argue that forest- and tree-focused environmental policies and conservation initiatives have potentially dire ecological consequences for undervalued ecosystems, such as grasslands, savannas, and open-canopy woodlands. To illustrate this forest bias and its consequences, ...

Researchers reawaken sleeping HIV in patient cells to eliminate the virus

2015-09-09
LA JOLLA, Calif., September 9, 2015 - A consortium of investigators led by scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found that a new class of drugs may be used to purge pockets of dormant HIV from a patient's body, eliminating the virus once and for all. Since these agents are already being explored in clinical trials for treating cancer, the route to approval for treating HIV may be significantly shorter than usual. Antiretroviral therapies have made it possible for people to live with HIV for decades. However, patients continue to ...

Battery-free smart camera nodes automatically determine their own pose and location

2015-09-09
Scientists at Disney Research and the University of Washington (UW) have shown that a network of energy-harvesting sensor nodes equipped with onboard cameras can automatically determine each camera's pose and location using optical cues. This capability could help to enable networks of hundreds or thousands of sensors that could operate without batteries or external power and require minimal maintenance. Such networks could be part of the Internet of Things (IoT) in which objects can communicate and share information to create smart environments. Previous work at UW ...

Ebola virus disease in Liberia

2015-09-09
A newly published research study by U.S. Forest Service researchers demonstrates that the social vulnerability indices used in climate change and natural hazards research can also be used in other contexts such as disease outbreaks. Authors of the article include Forest Service Southern Research Station (SRS) researchers John Stanturf, Scott Goodrick, Mel Warren, and Christie Stegall, and Susan Charnley from the Forest Service Pacific Northwest Research Station. Published in the online journal PLOS ONE, the study illustrates how census and household survey data, when ...

Study reveals need for better understanding of water use

2015-09-09
WEST LAFAYETTE, Ind. -- A new study reveals a pressing need to better understand water use in America's rivers, with implications for drought-stricken regions of the country. Findings from the study showed that virtually all of the water entering the Wabash River in Indiana during summer months is withdrawn and then returned to the waterway. "In a nutshell, in the summertime we generally use what is equivalent to the entire volume of the Wabash River so that by the time the river reaches the confluence of the Ohio River, the water in the Wabash on average has been through ...

This week from AGU: Mercury's spin, New Zealand fault, early-career scientists and research

2015-09-09
GeoSpace Mercury's movements give scientists peek inside the planet The first measurements of Mercury's movements from a spacecraft orbiting the planet reveal new insights about the makeup of the solar system's innermost world and its interactions with other planetary bodies, found a new study recently accepted in Geophysical Research Letters. New research calls for rethinking of New Zealand's Alpine Fault The major fault line of New Zealand's Alpine Fault, which runs almost the entire length of the South Island, has been assumed to be a near vertical crack. However, ...

High rate of Texas bugs carrying Chagas disease

High rate of Texas bugs carrying Chagas disease
2015-09-09
A deadly parasite that causes Chagas disease is widespread in a common Texas insect, according to a new study by University of Texas at El Paso (UTEP) researchers. The finding suggests that the risk of Texans contracting the disease may be higher than previously thought. The parasite Trypanosoma cruzi (T. cruzi), which causes Chagas disease can be transmitted to humans by blood-sucking insects known as "assassin bugs" or "kissing bugs." Unlike mosquitoes that transmit malaria through the bite, kissing bugs drop feces on the subject while filling up with blood. The feces, ...

Association of low resting heart rate in men and increased violent criminality

2015-09-09
A low resting heart rate in late adolescence was associated with increased risk for violent criminality in men later in life, according to an article published online by JAMA Psychiatry. Low resting heart rate is related to antisocial behavior in children and adolescents. Low resting heart rate (RHR) has been viewed either as an indicator of a chronically low level of psychological arousal, which may lead some people to seek stimulating experiences, or as a marker of weakened responses to aversive and stressful stimuli, which can lead to fearless behavior and risk taking. ...

Major complications, delirium associated with adverse events after elective surgery in older adults

2015-09-09
Among patients 70 years or older who underwent elective surgery, major complications contributed significantly to a prolonged length of hospital stay while delirium contributed significantly to several adverse outcomes, including length of stay and hospital readmission, according to a study published online by JAMA Surgery. Major postoperative complications and delirium contribute independently to adverse outcomes and high resource use in patients who undergo major surgery; however, their interrelationship has not been well examined. Understanding the risks of adverse ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Cells from human umbilical cord blood improve cognition in Alzheimer's disease model mice
Pretreated monocytes play a role in amyloid-β clearance, and may help confer positive effects for Alzheimer's disease sufferers
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.