Nontoxic cancer therapy proves effective against metastatic cancer

The mouse model study by University of South Florida researchers combined ketogenic diet and hyperbaric oxygen therapy

2013-06-06

(Press-News.org) Tampa, FL (June 5, 2013) -- A combination of nontoxic dietary and hyperbaric oxygen therapies effectively increased survival time in a mouse model of aggressive metastatic cancer, a research team from the Hyperbaric Biomedical Research Laboratory at the University of South Florida has found.

The study, "The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer," was published online today in PLOS ONE.

Led by Dominic D'Agostino, PhD, principal investigator in the Department of Molecular Pharmacology and Physiology at the USF Health Morsani College of Medicine, the research shows the effects of combining two nontoxic adjuvant cancer therapies, the ketogenic diet and hyperbaric oxygen therapy, in a mouse model of late-stage, metastatic cancer.

"Our study demonstrates the potential of these cost-effective, nontoxic therapies to contribute to current cancer treatment regimens and significantly improve the outcome of patients with advanced metastatic cancer," D'Agostino said.

Metastasis, the spreading of cancer from the primary tumor to distant spots, is responsible for over 90 percent of cancer-related deaths in humans. A lack of available therapies effective against metastatic disease remains the largest obstacle in finding a cure for cancer.

In the study, mice with advanced metastatic cancer were fed either a standard high carbohydrate diet or carbohydrate-restricted ketogenic diet. Mice on both diets also received hyperbaric oxygen therapy, which uses a special chamber to increase the amount of oxygen in the tissues.

The ketogenic diet forces a physiological shift in substrate utilization from glucose to fatty acids and ketone bodies for energy. Normal healthy cells readily adapt to using ketone bodies for fuel, but cancer cells lack this metabolic flexibility, and thus become selectively vulnerable to reduced glucose availability. Solid tumors also have areas of low oxygen, which promotes tumor growth and metastatic spread.

Hyperbaric oxygen therapy involves breathing 100 percent oxygen at elevated barometric pressure, saturating the tumors with oxygen. When administered properly, both the ketogenic diet and hyperbaric oxygen therapy are non-toxic and may even protect healthy tissues while simultaneously damaging cancer cells, D'Agostino said.

While both therapies slowed disease progression independently, animals receiving the combined ketogenic diet and hyperbaric oxygen therapy lived 78 percent longer than mice fed a standard high-carbohydrate diet.

The research, funded by a charitable donation from Scivation, was inspired by the research of Professor Thomas Seyfried of Boston College. Dr. Seyfried has advanced the theory that cancer is a metabolic disease, inspiring the development of metabolic strategies to treat and prevent cancer.

D`Agostino`s team is currently collaborating with Dr. Seyfried and other scientists to secure funding and develop protocols for establishing human clinical trials.

INFORMATION:

Article Citation:

"The Ketogenic Diet and Hyperbaric Oxygen Therapy Act Synergistically to Prolong Survival in Mice with Systemic Metastatic Cancer;" A.M. Poff, C. Ari, T.N. Seyfried and D.P. D'Agostino; PLOS ONE, June 5, 2013: http://dx.plos.org/10.1371/journal.pone.0065522

USF Health's mission is to envision and implement the future of health. It is the partnership of the USF Health Morsani College of Medicine, the College of Nursing, the College of Public Health, the College of Pharmacy, the School of Biomedical Sciences and the School of Physical Therapy and Rehabilitation Sciences; and the USF Physician's Group. The University of South Florida is a global research university ranked 50th in the nation by the National Science Foundation for both federal and total research expenditures among all U.S. universities. For more information, visit http://www.health.usf.edu

ELSE PRESS RELEASES FROM THIS DATE:

UCLA scientists isolate new population of pluripotent stem cells in fat removed during liposuction

2013-06-06

Researchers from the UCLA Department of Obstetrics and Gynecology have isolated a new population of primitive, stress-resistant human pluripotent stem cells easily derived from fat tissue that are able to differentiate into virtually every cell type in the human body without genetic modification. The cells, called Multi-lineage Stress-Enduring (Muse-AT) stem cells from fat, or adipose, tissue, were discovered by "scientific accident" when a piece of equipment failed in the lab, killing all the stem cells in the experiment except for the Muse-AT cells. The research team ...

Irish chronicles reveal links between cold weather and volcanic eruptions

2013-06-06

Medieval chronicles have given an international group of researchers a glimpse into the past to assess how historical volcanic eruptions affected the weather in Ireland up to 1500 years ago. By critically assessing over 40,000 written entries in the Irish Annals and comparing them with measurements taken from ice cores, the researchers successfully linked the climatic aftermath of volcanic eruptions to extreme cold weather events in Ireland over a 1200-year period from 431 to 1649. Their study, which has been published today, 6 June, in IOP Publishing's journal Environmental ...

First observation of spin Hall effect in a quantum gas is step toward 'atomtronics'

2013-06-06

Researchers at the National Institute of Standards and Technology (NIST) have reported* the first observation of the "spin Hall effect" in a Bose-Einstein condensate (BEC), a cloud of ultracold atoms acting as a single quantum object. As one consequence, they made the atoms, which spin like a child's top, skew to one side or the other, by an amount dependent on the spin direction. Besides offering new insight into the quantum mechanical world, they say the phenomenon is a step toward applications in "atomtronics"—the use of ultracold atoms as circuit components. The spin ...

Genetic mutation inherited from father's side linked to early puberty

2013-06-06

Boston, MA – Reaching puberty at an unusually early age can have adverse effects on social behavior and psychological development, as well as physical effects, including short stature, and lifelong health risks, such as diabetes, breast cancer and heart disease. Researchers at Brigham and Women's Hospital (BWH), in a multi-institutional collaboration with Boston Children's Hospital, the Broad Institute, and the University of Sao Paulo, Brazil, have identified that a genetic mutation leads to a type of premature puberty, known as central precocious puberty. Central precocious ...

Drug prevents post-traumatic stress-like symptoms in mice

2013-06-06

When injected into mice immediately following a traumatic event, a new drug prevents the animals from developing memory problems and increased anxiety that are indicative of post-traumatic stress disorder (PTSD). Howard Hughes Medical Institute scientists utilized mouse studies to suggest that a receptor called Oprl1 is altered in mice with PTSD-like symptoms. They then worked with a group at the Scripps Research Institute who had previously developed the Oprl1-targeted drug to examine its effects on fear memory modulation. The group has also shown that in humans, ...

University of Maryland School of Medicine finds gut bacteria play key role in vaccination

2013-06-06

Baltimore, Md. — June 5, 2013. The bacteria that live in the human gut may play an important role in immune response to vaccines and infection by wild-type enteric organisms, according to two recent studies resulting from a collaborative effort between the University of Maryland School of Medicine Institute for Genome Sciences and the Center for Vaccine Development. The first study, published online in PLOS ONE, http://umm.gd/13E3OHl, examines the impact of an oral typhoid vaccination on the microbiota, or populations of bacteria, in the human gut. The second study, also ...

Noble way to low-cost fuel cells, halogenated graphene may replace expensive platinum

2013-06-06

Ulsan, South Korea– The research team of Ulsan National Institute of Science and Technology (UNIST), Case Western Reserve University and University of North Texas have paved a new way for affordable commercialization of fuel cells with efficient metal-free electrocatalysts using edge-halogenated graphene nanoplatelets. Fuel cell technology has come a long way since the early days in the Apollo space program. Certainly the idea of running a car on pure hydrogen is an exciting prospect as the only emissions will be pure water. But how much will you be willing to pay ...

Ancient trapped water explains Earth's first ice age

2013-06-06

Tiny bubbles of water found in quartz grains in Australia may hold the key to understanding what caused the Earth's first ice age, say scientists. The Anglo-French study, published in the journal Nature, analysed the amount of ancient atmospheric argon gas (Ar) isotopes dissolved in the bubbles and found levels were very different to those in the air we breathe today. The researchers say their findings help explain why Earth didn't suffer its first ice age until 2.5 billion years ago, despite the Sun's rays being weaker during the early years of our planet's formation. "The ...

New study rebuts increase in willingness to cooperate from intuitive thinking

2013-06-06

The first study drew the conclusion that people cooperate more if they are forced to make decisions when pressed for time. The research group (Rand et al.) let the test subjects make decisions under pressure on social dilemmas. They found that the decisions made at the time were more oriented towards cooperation. The conclusion was that decisions under pressure that build on intuition promote cooperation. It has gotten a lot of attention and aroused a great deal of discussion. But it is not true, argues a group of researchers at several universities, including Linköping ...

Firefighting robot paints 3-D thermal imaging picture for rescuers

2013-06-06

Engineers in the Coordinated Robotics Lab at the University of California, San Diego, have developed new image processing techniques for rapid exploration and characterization of structural fires by small Segway-like robotic vehicles. A sophisticated on-board software system takes the thermal data recorded by the robot's small infrared camera and maps it onto a 3D scene constructed from the images taken by a pair of stereo RGB cameras. This allows small mobile robotic vehicles to create a virtual reality picture that includes a 3D map and temperature data that can ...