PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Prenatal exposure to BPA affects fat tissues in sheep

2013-06-17
(Press-News.org) SAN FRANCISCO-— New research suggests that fetal exposure to the common environmental chemical bisphenol A, or BPA, causes increased inflammation in fat tissues after birth, which can lead to obesity and metabolic syndrome. Results of the animal study were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

Found in plastic water bottles, older baby bottles and many other consumer products, BPA is a known hormone disrupter with estrogen-like properties. Prior research has linked BPA in both animals and humans to obesity and the metabolic syndrome, which is a cluster of metabolic risk factors that increase the chance of later developing diabetes, heart disease and stroke.

"This research is the first study to show that prenatal exposure to BPA increases postnatal fat tissue inflammation, a condition that underlies the onset of metabolic diseases such as obesity, diabetes and cardiovascular disease," said the study's lead author, Almudena Veiga-Lopez, DVM, PhD, a research investigator at the University of Michigan, Ann Arbor.

She said the study, which examines the effects of BPA on sheep, improves the understanding of how prenatal BPA exposure regulates the inflammatory response in offspring in the tissues that are relevant to development of metabolic disease. The study was conducted in the laboratory of Vasantha Padmanabhan, MS, PhD, Professor at the University of Michigan, Ann Arbor, with funding from the National Institutes of Health's National Institutes of Environmental Health Sciences. Veiga-Lopez said sheep have similar body fat to that in humans, including visceral (deep belly) fat and subcutaneous fat, which is directly below the skin.

The researchers fed two groups of pregnant sheep corn oil, either with nothing added to it or with added BPA at a dose needed to achieve BPA levels similar to those seen in human cord blood in the umbilical cord blood of the sheep offspring. Of the female offspring from the sheep, half from each group were overfed at approximately 6 weeks of age. All female offspring then were divided into four groups of nine to 12 animals each: (1) non-BPA-exposed controls that received a normal diet, (2) BPA-exposed offspring that received a normal diet, (3) overfed, obese controls and (4) overfed, obese BPA-exposed offspring.

At 15 months of age, sheep underwent a glucose tolerance test, to measure their insulin and blood sugar levels. Seven months later, the researchers collected samples of the animals' visceral and subcutaneous fat tissues to evaluate levels of two biological markers of inflammation. These biomarkers were CD68, a marker for inflammatory cells, and adiponectin, a molecule with a known role in the development of metabolic syndrome. When the adiponectin level decreases or CD68 expression increases, inflammation is worse, according to Veiga-Lopez.

Adiponectin was decreased and CD68 expression was raised in the visceral fat of both obese groups, and CD68 expression also was raised in the subcutaneous fat in normal weight, BPA-exposed female offspring, Veiga-Lopez reported. She said these results suggest that "prenatal BPA exposure and postnatal diet may interact to modulate inflammatory mechanisms in fat deposits."

Both obese groups had hyperinsulinemia, or high insulin levels, a precursor to insulin resistance, which is a prediabetic state, Veiga-Lopez reported. However, she said prenatal exposure to BPA did not lead to insulin resistance in sheep, as was true in a previous mouse study. She speculated that the hyperinsulinemia in obese offspring stems from changes that occurred in the two inflammatory markers in the visceral fat deposit.

###

Founded in 1916, The Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 16,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter.


ELSE PRESS RELEASES FROM THIS DATE:

Infections increase risk of mood disorders

2013-06-17
New research shows that every third person who is diagnosed for the first time with a mood disorder has been admitted to hospital with an infection prior to the diagnosis. The study is the largest of its kind to date to show a clear correlation between infection levels and the risk of developing mood disorders. Anyone can suffer from an infection, for example in their stomach, urinary tract or skin. It would now appear that their distress does not necessarily end once the infection has been treated. A new PhD project shows that many people subsequently suffer from a mood ...

Researchers find genetic diversity key to survival of honey bee colonies

2013-06-17
When it comes to honey bees, more mates is better. A new study from North Carolina State University, the University of Maryland and the U.S. Department of Agriculture (USDA) shows that genetic diversity is key to survival in honey bee colonies – meaning a colony is less likely to survive if its queen has had a limited number of mates. "We wanted to determine whether a colony's genetic diversity has an impact on its survival, and what that impact may be," says Dr. David Tarpy, an associate professor of entomology at North Carolina State University and lead author of a ...

Study identifies travel choices for a smaller carbon footprint

2013-06-17
The study, published in the journal Environmental Science and Technology by researchers at IIASA and Center for International Climate and Environmental Research (CICERO) calculates the climate impact for passenger trips of 500-1000 km—typical distances for business or holiday trips. It shows that while air travel continues to have the biggest climate impact per distance travelled, the choices that people make about how they drive or take public transport make a big difference in how much they contribute to climate change. "Traveling alone in a large car can be as bad ...

CWRU study finds babies witnessing violence show aggression later in school

2013-06-17
Aggression in school-age children may have its origins in children 3 years old and younger who witnessed violence between their mothers and partners, according to a new Case Western Reserve University study. "People may think children that young are passive and unaware, but they pay attention to what's happening around them," said Megan Holmes, assistant professor of social work at the Jack, Joseph and Morton Mandel School of Applied Social Sciences at Case Western Reserve in Cleveland. Between three and 10 million children witness some form of domestic violence each ...

Certain types of graft-versus-host disease may increase risk of death, Moffitt researcher says

2013-06-17
Joseph Pidala, M.D., M.S., assistant member of the Blood and Bone Marrow Transplant and Immunology programs at Moffitt Cancer Center, and colleagues from the Chronic Graft-Versus-Host Disease Consortium have determined that certain gastrointestinal and liver-related types of chronic graft-versus-host disease (GVHD) are associated with worsened quality of life and death. Their study appeared in the May issue of Biology of Blood and Marrow Transplantation, the official journal of the American Society for Blood and Marrow Transplantation. GVHD is a complication that can ...

Slow and steady wins the baggage search

2013-06-17
DURHAM, N.C. -- Next time you're doing a slow burn in security screening at the airport, calm yourself with the assurance that a more deliberate baggage scanner may do a better job. In a laboratory test of visual searching ability, scientists found trained Transportation Security Administration (TSA) screening officers were a lot slower than undergraduate students and other civilians. But the amateurs were sloppier. The test is part of ongoing research by Duke University psychologist Stephen Mitroff to understand how the brain manages visual searching, which is important ...

Intelligent glasses designed for professors

2013-06-17
This news release is available in Spanish. The proposed system (Augmented Lecture Feedback System – ALFs) seeks to improve communication between students and professors during large lecture classes like those frequently given at universities. The way they work is quite intuitive: the professor wears a pair of augmented reality glasses that enable him/her to see symbols above each student; the symbols indicate the person's state while this activity is taking place. "These symbols are activated by the students via their cell phones and are used to tell the professor ...

Bariatric surgery restores nerve cell properties altered by diet

2013-06-17
Understanding how gastric bypass surgery changes the properties of nerve cells that help regulate the digestive system could lead to new treatments that produce the same results without surgery, according to Penn State College of Medicine scientists, who have shown how surgery restores some properties of nerve cells that tell people their stomachs are full. The results may also better predict which patients will keep the weight off after surgery. Roux-en-Y gastric bypass surgery is the most effective way to get severe obesity under control. Doctors make the stomach ...

Throwing the bum out: When should scandal-hit politicians stage a come back?

2013-06-17
As Anthony Weiner enters the New York mayoral race two years after scandal forced him from office, a new study in Social Science Quarterly explores the lingering effect of scandals and asks how long a politician need wait before hitting the come-back trail. Using research into 'brand crisis' this study is the first systematic test of the idea that scandals can linger in voters' minds and damage a politician's reelection campaign. The authors find evidence that this lingering effect ensures politicians do not return to their pre-scandal predicted margins of victory until ...

How useful is fracking anyway? Study explores return of investment

2013-06-17
The value of a fuel's long-term usefulness and viability is judged through its energy return on investment; the comparison between the eventual fuel and the energy invested to create it. The energy return on investment (EROI) study published in the Journal of Industrial Ecology finds that shale gas has a return value which is close to coal. In the United States, gas is mined from horizontal, hydraulically fractured wells in the Marcellus Shale of Pennsylvania. The study compares the total input energy with the energy expected to be made available to end users. The ...

LAST 30 PRESS RELEASES:

Inability to pay for healthcare reaches record high in U.S.

Science ‘storytelling’ urgently needed amid climate and biodiversity crisis

KAIST Develops Retinal Therapy to Restore Lost Vision​

Adipocyte-hepatocyte signaling mechanism uncovered in endoplasmic reticulum stress response

Mammals were adapting from life in the trees to living on the ground before dinosaur-killing asteroid

Low LDL cholesterol levels linked to reduced risk of dementia

Thickening of the eye’s retina associated with greater risk and severity of postoperative delirium in older patients

Almost one in ten people surveyed report having been harmed by the NHS in the last three years

Enhancing light control with complex frequency excitations

New research finds novel drug target for acute myeloid leukemia, bringing hope for cancer patients

New insight into factors associated with a common disease among dogs and humans

Illuminating single atoms for sustainable propylene production

New study finds Rocky Mountain snow contamination

Study examines lactation in critically ill patients

UVA Engineering Dean Jennifer West earns AIMBE’s 2025 Pierre Galletti Award

Doubling down on metasurfaces

New Cedars-Sinai study shows how specialized diet can improve gut disorders

Making moves and hitting the breaks: Owl journeys surprise researchers in western Montana

PKU Scientists simulate the origin and evolution of the North Atlantic Oscillation

ICRAFT breakthrough: Unlocking A20’s dual role in cancer immunotherapy

How VR technology is changing the game for Alzheimer’s disease

A borrowed bacterial gene allowed some marine diatoms to live on a seaweed diet

Balance between two competing nerve proteins deters symptoms of autism in mice

Use of antifungals in agriculture may increase resistance in an infectious yeast

Awareness grows of cancer risk from alcohol consumption, survey finds

The experts that can outsmart optical illusions

Pregnancy may reduce long COVID risk

Scientists uncover novel immune mechanism in wheat tandem kinase

Three University of Virginia Engineering faculty elected as AAAS Fellows

Unintentional drug overdoses take a toll across the U.S. unequally, study finds

[Press-News.org] Prenatal exposure to BPA affects fat tissues in sheep