PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

How cranberries impact infection-causing bacteria

Research points to potential role for cranberry derivatives in implantable medical devices

2013-07-15
(Press-News.org) Consuming cranberry products has been anecdotally associated with prevention of urinary tract infections (UTIs) for over 100 years. But is this popular belief a myth, or scientific fact?

In recent years, some studies have suggested that cranberries prevent UTIs by hindering bacteria from sticking to the walls of the urinary tract, thanks to phytochemicals known as proanthocyanidins (PACs). Yet the mechanisms by which cranberry materials may alter bacterial behaviour have not been fully understood.

Now, researchers in McGill University's Department of Chemical Engineering are shedding light on the biological mechanisms by which cranberries may impart protective properties against urinary tract and other infections. Two new studies, spearheaded by Prof. Nathalie Tufenkji, add to evidence of cranberries' effects on UTI-causing bacteria. The findings also point to the potential for cranberry derivatives to be used to prevent bacterial colonization in medical devices such as catheters.

In research results published online last month in the Canadian Journal of Microbiology, Prof. Tufenkji and members of her laboratory report that cranberry powder can inhibit the ability of Proteus mirabilis, a bacterium frequently implicated in complicated UTIs, to swarm on agar plates and swim within the agar. The experiments also show that increasing concentrations of cranberry powder reduce the bacteria's production of urease, an enzyme that contributes to the virulence of infections.

These results build on previous work by the McGill lab, showing that cranberry materials hinder movement of other bacteria involved in UTIs. A genome-wide analysis of an uropathogenic E. coli revealed that expression of the gene that encodes for the bacteria's flagellar filament was decreased in the presence of cranberry PACs.

The team's findings are significant because bacterial movement is a key mechanism for the spread of infection, as infectious bacteria literally swim to disseminate in the urinary tract and to escape the host immune response.

"While the effects of cranberry in living organisms remain subject to further study, our findings highlight the role that cranberry consumption might play in the prevention of chronic infections," Tufenkji says. "More than 150 million cases of UTI are reported globally each year, and antibiotic treatment remains the standard approach for managing these infections. The current rise of bacterial resistance to antibiotics underscores the importance of developing another approach."

Another recent study led by Tufenkji in collaboration with McGill professor Showan Nazhat, a biomaterials expert at the Department of Mining and Materials Engineering, finds that cranberry-enriched silicone substrates impaired the spread of Proteus mirabilis. Those results, published online in the journal Colloids and Surfaces B: Biointerfaces, point to potential use for cranberry derivatives to hinder the spread of germs in implantable medical devices such as catheters, which are frequently implicated in UTIs.

"Based on the demonstrated bioactivity of cranberry, its use in catheters and other medical devices could someday yield considerable benefits to patient health," Tufenkji says.



INFORMATION:



Funding for the new studies was provided by the Natural Sciences and Engineering Research Council of Canada, the Canada Research Chairs program, the Wisconsin Cranberry Board, the Cranberry Institute, the Fonds québécois de la recherche sur la nature et les technologies, and the Fonds de la recherche en santé du Québec.

Link to the Canadian Journal of Microbiology article: http://www.nrcresearchpress.com/doi/abs/10.1139/cjm-2012-0744#.UctRHjvqlLc

Link to the Colloids and Surfaces B: Biointerfaces article: http://www.sciencedirect.com/science/article/pii/S0927776513002348



ELSE PRESS RELEASES FROM THIS DATE:

Researchers question practice of automatically transfusing large amounts of blood to trauma patients

2013-07-15
TORONTO, July 15, 2013—Researchers at St. Michael's Hospital are asking questions about the practice of automatically transfusing large amounts of blood and blood products to trauma patients with major bleeding. Trauma patients were resuscitated primarily with blood until the second part of the 20th century when the practice was modified so that blood transfusions were given only after lab tests suggested they were needed. The idea of resuscitating primarily with blood was revived after U.S. military physicians in Iraq and Afghanistan reported in 2007 that this practice ...

RI Hospital study: Lunar cycle affects cardiac patients undergoing acute aortic dissection

2013-07-15
PROVIDENCE, R.I. – If you need cardiac surgery in the future, aortic dissection in particular, reach for the moon. Or at least try to schedule your surgery around its cycle. According to a study at Rhode Island Hospital, acute aortic dissection (AAD) repair performed in the waning full moon appears to reduce the odds of death, and a full moon was associated with shorter length of stay (LOS). The study is published online in advance of print in the journal Interactive Cardiovascular and Thoracic Surgery. The purpose of the study was to assess the effect of natural time ...

Boldly illuminating biology's 'dark matter'

2013-07-15
Is space really the final frontier, or are the greatest mysteries closer to home? In cosmology, dark matter is said to account for the majority of mass in the universe, however its presence is inferred by indirect effects rather than detected through telescopes. The biological equivalent is "microbial dark matter," that pervasive yet practically invisible infrastructure of life on the planet, which can have profound influences on the most significant environmental processes from plant growth and health, to nutrient cycles in terrestrial and marine environments, the global ...

Drug candidate designed at Scripps Research Institute leads to improved endurance

2013-07-15
JUPITER, FL, July 14, 2013 – An international group of scientists has shown that a drug candidate designed by scientists from the Florida campus of The Scripps Research Institute (TSRI) significantly increases exercise endurance in animal models. These findings could lead to new approaches to helping people with conditions that acutely limit exercise tolerance, such as obesity, chronic obstructive pulmonary disease (COPD) and congestive heart failure, as well as the decline of muscle capacity associated with aging. The study was published July 14, 2013, by the journal ...

NIH scientists find that proteins involved in immunity potentially cause cancer

2013-07-15
A set of proteins involved in the body's natural defenses produces a large number of mutations in human DNA, according to a study led by researchers at the National Institutes of Health. The findings suggest that these naturally produced mutations are just as powerful as known cancer-causing agents in producing tumors. The proteins are part of a group called apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) cytidine deaminases. The investigators found that APOBEC mutations can outnumber all other mutations in some cancers, accounting for over two-thirds ...

DNA abnormalities may contribute to cancer risk in people with type 2 diabetes

2013-07-15
A type of genetic abnormality linked to cancer is more common in people with type 2 diabetes than the rest of the population, a new study has found. People with type 2 diabetes are already known to have a higher risk of cancers, especially blood cancers like lymphoma and leukaemia. The new study, led by scientists at Imperial College London and CNRS in France, suggests that mutations called clonal mosaic events (CMEs) may partly explain why this is. CMEs are defects that result in some cells having extra copies or missing copies of large chunks of DNA. They are very ...

Imaging electron pairing in a simple magnetic superconductor

2013-07-15
UPTON, NY-In the search for understanding how some magnetic materials can be transformed to carry electric current with no energy loss, scientists at the U.S. Department of Energy's Brookhaven National Laboratory, Cornell University, and collaborators have made an important advance: Using an experimental technique they developed to measure the energy required for electrons to pair up and how that energy varies with direction, they've identified the factors needed for magnetically mediated superconductivity-as well as those that aren't. "Our measurements distinguish energy ...

Key step in molecular 'dance' that duplicates DNA deciphered

2013-07-15
UPTON, NY-Building on earlier work exploring the complex choreography by which intricate cellular proteins interact with and copy DNA prior to cell division, scientists at the U.S. Department of Energy's Brookhaven National Laboratory and collaborators have captured a key step-molecular images showing how the enzyme that unwinds the DNA double helix gets drawn to and wrapped around its target. Details of the research, published in the journal Nature Structural & Molecular Biology, enhance understanding of an essential biological process and may suggest ways for stopping ...

Continuous satellite monitoring of ice sheets needed to better predict sea-level rise

2013-07-15
The findings, published in Nature Geoscience, underscore the need for continuous satellite monitoring of the ice sheets to better identify and predict melting and the corresponding sea-level rise. The ice sheets covering Antarctica and Greenland contain about 99.5 per cent of the Earth's glacier ice which would raise global sea level by some 63m if it were to melt completely. The ice sheets are the largest potential source of future sea level rise – and they also possess the largest uncertainty over their future behaviour. They present some unique challenges for predicting ...

Some volcanoes 'scream' at ever-higher pitches until they blow their tops

2013-07-15
It is not unusual for swarms of small earthquakes to precede a volcanic eruption. They can reach a point of such rapid succession that they create a signal called harmonic tremor that resembles sound made by various types of musical instruments, though at frequencies much lower than humans can hear. A new analysis of an eruption sequence at Alaska's Redoubt Volcano in March 2009 shows that the harmonic tremor glided to substantially higher frequencies and then stopped abruptly just before six of the eruptions, five of them coming in succession. "The frequency of this ...

LAST 30 PRESS RELEASES:

Inability to pay for healthcare reaches record high in U.S.

Science ‘storytelling’ urgently needed amid climate and biodiversity crisis

KAIST Develops Retinal Therapy to Restore Lost Vision​

Adipocyte-hepatocyte signaling mechanism uncovered in endoplasmic reticulum stress response

Mammals were adapting from life in the trees to living on the ground before dinosaur-killing asteroid

Low LDL cholesterol levels linked to reduced risk of dementia

Thickening of the eye’s retina associated with greater risk and severity of postoperative delirium in older patients

Almost one in ten people surveyed report having been harmed by the NHS in the last three years

Enhancing light control with complex frequency excitations

New research finds novel drug target for acute myeloid leukemia, bringing hope for cancer patients

New insight into factors associated with a common disease among dogs and humans

Illuminating single atoms for sustainable propylene production

New study finds Rocky Mountain snow contamination

Study examines lactation in critically ill patients

UVA Engineering Dean Jennifer West earns AIMBE’s 2025 Pierre Galletti Award

Doubling down on metasurfaces

New Cedars-Sinai study shows how specialized diet can improve gut disorders

Making moves and hitting the breaks: Owl journeys surprise researchers in western Montana

PKU Scientists simulate the origin and evolution of the North Atlantic Oscillation

ICRAFT breakthrough: Unlocking A20’s dual role in cancer immunotherapy

How VR technology is changing the game for Alzheimer’s disease

A borrowed bacterial gene allowed some marine diatoms to live on a seaweed diet

Balance between two competing nerve proteins deters symptoms of autism in mice

Use of antifungals in agriculture may increase resistance in an infectious yeast

Awareness grows of cancer risk from alcohol consumption, survey finds

The experts that can outsmart optical illusions

Pregnancy may reduce long COVID risk

Scientists uncover novel immune mechanism in wheat tandem kinase

Three University of Virginia Engineering faculty elected as AAAS Fellows

Unintentional drug overdoses take a toll across the U.S. unequally, study finds

[Press-News.org] How cranberries impact infection-causing bacteria
Research points to potential role for cranberry derivatives in implantable medical devices