Making the brain take notice of faces in autism

A new study in Biological Psychiatry explores the influence of oxytocin

2013-08-15

(Press-News.org) Philadelphia, PA, August 15, 2013 – Difficulty in registering and responding to the facial expressions of other people is a hallmark of autism spectrum disorder (ASD). Relatedly, functional imaging studies have shown that individuals with ASD display altered brain activations when processing facial images.

The hormone oxytocin plays a vital role in the social interactions of both animals and humans. In fact, multiple studies conducted with healthy volunteers have provided evidence for beneficial effects of oxytocin in terms of increased trust, improved emotion recognition, and preference for social stimuli.

This combination of scientific work led German researchers to hypothesize about the influence of oxytocin in ASD. Dr. Gregor Domes, from the University of Freiburg and first author of the new study, explained: "In the present study, we were interested in the question of whether a single dose of oxytocin would change brain responses to social compared to non-social stimuli in individuals with autism spectrum disorder."

They found that oxytocin did show an effect on social processing in the individuals with ASD, "suggesting that oxytocin may help to treat a basic brain function that goes awry in autism spectrum disorders," commented Dr. John Krystal, Editor of Biological Psychiatry.

To conduct this study, they recruited fourteen individuals with ASD and fourteen control volunteers, all of whom completed a face- and house-matching task while undergoing imaging scans. Each participant completed this task and scanning procedure twice, once after receiving a nasal spray containing oxytocin and once after receiving a nasal spray containing placebo. The order of the sprays was randomized, and the tests were administered one week apart.

Using two sets of stimuli in the matching task, one of faces and one of houses, allowed the researchers to not only compare the effects of the oxytocin and placebo administrations, but also allowed them to discriminate findings between specific effects to only social stimuli and non-specific effects to more general brain processing.

What they found was intriguing. The data indicate that oxytocin specifically increases responses of the amygdala to social stimuli in individuals with ASD. The amygdala, the authors explain, "has been associated with processing of emotional stimuli, threat-related stimuli, face processing, and vigilance for salient stimuli".

This finding suggests oxytocin might promote the salience of social stimuli in ASD. Increased salience of social stimuli might support behavioral training of social skills in ASD.

These data support the idea that oxytocin may be a promising approach in the treatment of ASD and could stimulate further research, even clinical trials, on the exploration of oxytocin as an add-on treatment for individuals with autism spectrum disorder.

### The article is "Effects of Intranasal Oxytocin on the Neural Basis of Face Processing in Autism Spectrum Disorder" by Gregor Domes, Markus Heinrichs, Ekkehardt Kumbier, Annette Grossmann, Karlheinz Hauenstein, and Sabine C. Herpertz (doi: 10.1016/j.biopsych.2013.02.007). The article appears in Biological Psychiatry, Volume 74, Issue 3 (August 1, 2013), published by Elsevier.

Notes for Editors Full text of the article is available to credentialed journalists upon request; contact Rhiannon Bugno at +1 214 648 0880 or Biol.Psych@utsouthwestern.edu. Journalists wishing to interview the authors may contact Dr. Gregor Domes at +49 761 203 3035 or domes@psychologie.uni-freiburg.de.

The authors' affiliations, and disclosures of financial and conflicts of interests are available in the article.

John H. Krystal, M.D., is Chairman of the Department of Psychiatry at the Yale University School of Medicine and a research psychiatrist at the VA Connecticut Healthcare System. His disclosures of financial and conflicts of interests are available here.

About Biological Psychiatry Biological Psychiatry is the official journal of the Society of Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal publishes both basic and clinical contributions from all disciplines and research areas relevant to the pathophysiology and treatment of major psychiatric disorders.

The journal publishes novel results of original research which represent an important new lead or significant impact on the field, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. Reviews and commentaries that focus on topics of current research and interest are also encouraged.

Biological Psychiatry is one of the most selective and highly cited journals in the field of psychiatric neuroscience. It is ranked 4th out of 135 Psychiatry titles and 13th out of 251 Neurosciences titles in the Journal Citations Reports® published by Thomson Reuters. The 2012 Impact Factor score for Biological Psychiatry is 9.247.

About Elsevier Elsevier is a world-leading provider of scientific, technical and medical information products and services. The company works in partnership with the global science and health communities to publish more than 2,000 journals, including The Lancet and Cell, and close to 20,000 book titles, including major reference works from Mosby and Saunders. Elsevier's online solutions include ScienceDirect, Scopus, SciVal, Reaxys, ClinicalKey and Mosby's Suite, which enhance the productivity of science and health professionals, helping research and health care institutions deliver better outcomes more cost-effectively.

A global business headquartered in Amsterdam, Elsevier employs 7,000 people worldwide. The company is part of Reed Elsevier Group plc, a world leading provider of professional information solutions. The group employs more than 30,000 people, including more than 15,000 in North America. Reed Elsevier Group plc is owned equally by two parent companies, Reed Elsevier PLC and Reed Elsevier NV. Their shares are traded on the London, Amsterdam and New York Stock Exchanges using the following ticker symbols: London: REL; Amsterdam: REN; New York: RUK and ENL.

ELSE PRESS RELEASES FROM THIS DATE:

Heartbeats link mind and body together

2013-08-15

While we're not necessarily aware of our heartbeat, this inner rhythm actually contributes to how we experience the body, and what belongs to it, according to research recently conducted at EPFL. A study to be published in the journal Psychological Science later this year supports the idea that signals from our internal organs combine with visual information to contribute to self-consciousness. "The relevance of internal organs for identifying the self was determined over a decade ago," says EPFL researcher Olaf Blanke. "What is new about our approach and findings is that ...

Characteristics of family killers revealed by first taxonomy study

2013-08-15

Of all the dark forms that murder can take, the slaying of a family by the father is one of the most tragic and the least understood. This first ever study of British 'family annihilators', published in the Howard Journal of Criminal Justice, has analysed three decades of cases and reveals four new types of annihilator. "Family annihilators have received little attention as a separate category of killer," said Professor David Wilson, one of the paper's three authors, and Director of the Centre of Applied Criminology at Birmingham City University. "Often they are treated ...

Quantum teleportation: Transfer of flying quantum bits at the touch of a button

2013-08-15

By means of the quantum-mechanical entanglement of spatially separated light fields, researchers in Tokyo and Mainz have managed to teleport photonic qubits with extreme reliability. This means that a decisive breakthrough has been achieved some 15 years after the first experiments in the field of optical teleportation. The success of the experiment conducted in Tokyo is attributable to the use of a hybrid technique in which two conceptually different and previously incompatible approaches were combined. "Discrete digital optical quantum information can now be transmitted ...

Will to win forms at 4 years old

2013-08-15

New research suggests children don't understand competitive behaviour until around the age of four. A team of researchers from the University of Warwick and University of Salzburg found most children under 4 did not have a developed understanding of other people's perspectives — specifically, of the fact that what someone intentionally does depends on their take on the situation. Johannes Roessler, from the Department of Philosophy at the University of Warwick, and his co-authors Beate Priewasser and Josef Perner from the Department of Psychology at the University ...

Researchers report a critical role for the complement system in early macular degeneration

2013-08-15

BOSTON (August 15, 2013) -- In a study published on line this week in the journal Human Molecular Genetics, Drs. Donita Garland, Rosario Fernandez-Godino, and Eric Pierce of the Ocular Genomics Institute at the Massachusetts Eye and Ear, Harvard Medical School, along with their colleagues, reported the unexpected finding that in mice genetically engineered to have an inherited form of macular degeneration, turning off the animals' complement system, a part of the immune system, prevented the disease. Macular degenerations, which occur in several forms, are important ...

Beating blindness with vegetable oil

2013-08-15

Scientists working at the Research Center on Aging at the Health and Social Services Centre — University Institute of Geriatrics of Sherbrooke (CSSS-IUGS) have been studying strategies for protecting retinal pigment epithelium (RPE) cells. Dysfunction of the RPE is found in retinopathy and age-related macular degeneration, which is the leading cause of blindness of elderly people in developed countries. Findings published today in the Canadian Journal of Physiology and Pharmacology suggest that incubating retinal cells with vegetable oils induces biochemical and biophysical ...

Rice technique expands options for molecular imaging

2013-08-15

HOUSTON -- (Aug. 15, 2013) -- A Rice University laboratory has improved upon its ability to determine molecular structures in three dimensions in ways that challenge long-used standards. By measuring the vibrations between atoms using femtosecond-long laser pulses, the Rice lab of chemist Junrong Zheng is able to discern the positions of atoms within molecules without the restrictions imposed by X-ray diffraction (XRD) and nuclear magnetic resonance (NMR) imaging. The technique can capture the structure of molecules at room temperature or very low or high temperatures ...

New model helps universities map their nitrogen footprint

2013-08-15

New Rochelle, NY, August 15, 2013—The first institution-level model to estimate the amount of reactive nitrogen released into the environment—a contributor to smog, acid rain, and climate change—is enabling the University of Virginia to quantify its nitrogen footprint and take steps to reduce it. A detailed description of this cutting-edge tool and how it can help improve institutional sustainability is presented in Sustainability: The Journal of Record a publication of Mary Ann Liebert, Inc., publishers. The Open Access article is available on the Sustainability: The Journal ...

Growth of disorder of electrons measured in dual temperature system

2013-08-15

Researchers at Aalto University, Finland and the University of Tokyo have succeeded for the first time in experimentally measuring a probability distribution for entropy production of electrons. Entropy production means an increase in disorder when electrons are moved individually between two microscopic conductors of differing temperatures. The researchers also showed that a connection prevails between two definitions of entropy that have been used. The result is significant for the design of future nanoelectronic devices. The study was published recently in the scientific ...

First time: NJIT researchers examine dynamics of liquid metal particles at nanoscale

2013-08-15

Two NJIT researchers have demonstrated that using a continuum-based approach, they can explain the dynamics of liquid metal particles on a substrate of a nanoscale. "Numerical simulation of ejected molten metal nanoparticles liquified by laser irradiation: Interplay of geometry and dewetting," appeared in Physical Review Letters (July 16, 2013). The evolution of fluid drops deposited on solid substrates has been a focus of large research effort for decades, said co-author Shahriar Afkhami, an assistant professor in the NJIT Department of Mathematical Sciences. This ...

Children who grow up with pets or on farms may develop allergies at lower rates because their gut microbiome develops with more anaerobic commensals, per fecal analysis in small cohort study

North American Early Paleoindians almost 13,000 years ago used the bones of canids, felids, and hares to create needles in modern-day Wyoming, potentially to make the tailored fur garments which enabl

Higher levels of democracy and lower levels of corruption are associated with more doctors, independent of healthcare spending, per cross-sectional study of 134 countries

Making the brain take notice of faces in autism

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: