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Autistic kids who best peers at math show different brain organization, Stanford/Packard study shows

2013-08-16
(Press-News.org) STANFORD, Calif. — Children with autism and average IQs consistently demonstrated superior math skills compared with nonautistic children in the same IQ range, according to a study by researchers at the Stanford University School of Medicine and Lucile Packard Children's Hospital.

"There appears to be a unique pattern of brain organization that underlies superior problem-solving abilities in children with autism," said Vinod Menon, PhD, professor of psychiatry and behavioral sciences and a member of the Child Health Research Institute at Packard Children's.

The autistic children's enhanced math abilities were tied to patterns of activation in a particular area of their brains — an area normally associated with recognizing faces and visual objects.

Menon is senior author of the study, published online Aug. 17 in Biological Psychiatry. Postdoctoral scholar Teresa Iuculano, PhD, is the lead author.

Children with autism have difficulty with social interactions, especially interpreting nonverbal cues in face-to-face conversations. They often engage in repetitive behaviors and have a restricted range of interests.

But in addition to such deficits, children with autism sometimes exhibit exceptional skills or talents, known as savant abilities. For example, some can instantly recall the day of the week of any calendar date within a particular range of years — for example, that May 21, 1982, was a Friday. And some display superior mathematical skills.

"Remembering calendar dates is probably not going to help you with academic and professional success," Menon said. "But being able to solve numerical problems and developing good mathematical skills could make a big difference in the life of a child with autism."

The idea that people with autism could employ such skills in jobs, and get satisfaction from doing so, has been gaining ground in recent years.

The participants in the study were 36 children, ages 7 to 12. Half had been diagnosed with autism. The other half was the control group. Each group had 14 boys and four girls. (Autism disproportionately affects boys.) All participants had IQs in the normal range and showed normal verbal and reading skills on standardized tests administered as part of the recruitment process for the study. But on the standardized math tests that were administered, the children with autism outperformed children in the control group.

After the math test, researchers interviewed the children to assess which types of problem-solving strategies each had used: Simply remembering an answer they already knew; counting on their fingers or in their heads; or breaking the problem down into components — a comparatively sophisticated method called decomposition. The children with autism displayed greater use of decomposition strategies, suggesting that more analytic strategies, rather than rote memory, were the source of their enhanced abilities.

Then, the children worked on solving math problems while their brain activity was measured in an MRI scanner, in which they had to lie down and remain still. The brain scans of the autistic children revealed an unusual pattern of activity in the ventral temporal occipital cortex, an area specialized for processing visual objects, including faces.

"Our findings suggest that altered patterns of brain organization in areas typically devoted to face processing may underlie the ability of children with autism to develop specialized skills in numerical problem solving," Iuculano said.

Menon added that previous research "has focused almost exclusively on weaknesses in children with autism. Our study supports the idea that the atypical brain development in autism can lead, not just to deficits, but also to some remarkable cognitive strengths. We think this can be reassuring to parents."

The research team is now gathering data from a larger group of children with autism to learn more about individual differences in their mathematical abilities. Menon emphasized that not all children with autism have superior math abilities, and that understanding the neural basis of variations in problem-solving abilities is an important topic for future research.

"These findings not only empirically confirm that high-functioning children with autism have especially strong number-problem-solving abilities, but show that this cognitive strength in math is based on different patterns of functional brain organization," said Carl Feinstein, MD, director of the Center for Autism and Related Disorders at Packard Children's and professor of psychiatry and behavioral sciences at the School of Medicine. He was not involved in the study.

### Other Stanford co-authors are postdoctoral scholars Miriam Rosenberg-Lee, PhD, and Kaustubh Supekar, PhD; social science research assistants Charles Lynch and Amirah Khouzam; Jennifer Phillips, PhD, clinical associate professor of psychiatry and behavioral sciences and a clinical psychologist at Packard Children's; and Lucina Uddin, PhD, instructor in psychiatry and behavioral sciences.

The study was funded by grants from the Singer Foundation, the Stanford Institute for Neuro-Innovation & Translational Neurosciences, and the National Institutes of Health (grant MH084164).

Information about Stanford's Department of Psychiatry & Behavioral Sciences, which also supported the work, is available at http://psychiatry.stanford.edu.

The Stanford University School of Medicine consistently ranks among the nation's top medical schools, integrating research, medical education, patient care and community service. For more news about the school, please visit http://mednews.stanford.edu. The medical school is part of Stanford Medicine, which includes Stanford Hospital & Clinics and Lucile Packard Children's Hospital. For information about all three, please visit http://stanfordmedicine.org/about/news.html.

Lucile Packard Children's Hospital at Stanford is an internationally recognized 311-bed hospital and leading regional medical network providing a full complement of services for the health of children and expectant mothers. Together, our world-class Stanford Medicine doctors, nurses and staff deliver innovative, nurturing care and extraordinary outcomes in every pediatric and obstetric specialty. Packard Children's is annually ranked as one of the nation's finest by U.S. News & World Report and the only Northern California children's hospital with specialty programs ranked in the U.S. News Top 10. Learn more about our full range of pre-eminent programs at lpch.org and the Packard Children's Health Alliance at PCHA.org. Like us on Facebook, watch us on YouTube and follow us on Twitter.

PRINT MEDIA CONTACT: Louis Bergeron at (650) 724-9175 (louisb3@stanford.edu) BROADCAST MEDIA CONTACT: Winter Johnson at (650) 498-7956 (wijohnson@lpch.org)


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[Press-News.org] Autistic kids who best peers at math show different brain organization, Stanford/Packard study shows