(Press-News.org) Roll-out of voluntary male circumcision services into the community of Orange Farm, South Africa is linked to substantial reductions in HIV infection levels, according to a study published in this week's PLOS Medicine. The study, (ANRS-12126), conducted by Bertran Auvert and colleagues from the University of Versailles (France), also reported that substantial uptake of voluntary male circumcision in one community was not linked to changes in sexual behavior that might affect HIV infection rates.
In this study, Bertran Auvert and colleagues estimated HIV infection levels in men associated with the implementation of the Bophelo Pele project, a community-based campaign against HIV that was initiated in 2008 and that includes free voluntary male circumcision services. Approximately 18,000 circumcision procedures on adult men were performed between 2008 and 2010.
Using information from surveys, the researchers observed that 12% of the men surveyed had been circumcised before the implementation of the Bophelo Pele project whereas in the follow-up survey, the overall rate of circumcision increased to 53% of the men surveyed. The overall HIV rate at follow-up was 12% and the researchers estimated that without the circumcision procedures performed during the Bophelo Pele project, the rate of HIV among men living in this community would have been 15% in 2011. The findings suggest that circumcision was also linked to a reduced number of new HIV infections but the methods used in this study cannot prove cause and effect. However, importantly, there was no evidence of a link between circumcision status and risky sexual behavior.
The authors say: "This study suggests that the roll-out of adult [voluntary medical male circumcision] is associated with a reduction in HIV in a sub-Saharan community where [male circumcision] is not a social norm."
They continue: " The main implication of this study is that the current roll-out of adult [voluntary medical male circumcision], endorsed by UNAIDS and WHO, and supported by international agencies such as PEPFAR, the Global Fund, and by donors like the Bill and Melinda gates Foundation, should be accelerated."
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Funding: Funding and sponsorship for this study was provided by the French Agency for AIDS and Viral Hepatitis Research (ANRS; grant 12126). Additional funding was provided by the Bill and Melinda Gates Foundation (BMGF; USA; OPP1021324), and PEPFAR (USA) through USAID. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: GP has received travel grants, consultancy fees, honoraria, or study grants from various pharmaceutical companies including Abbott, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck, Roche, Splicos, and ViiV Healthcare. GP is a member of different committees of the French National Agency for Research on AIDS and Viral Hepatitis (HIV Pharmacology, HIV Resistance, Therapeutic Strategy on HIV and Viral Hepatitis). All other authors have declared that no competing interests exist.
Citation: Auvert B, Taljaard D, Rech D, Lissouba P, Singh B, et al. (2013) Association of the ANRS-12126 Male Circumcision Project with HIV Levels among Men in a South African Township: Evaluation of Effectiveness using Cross-sectional Surveys. PLoS Med 10(9): e1001509. doi:10.1371/journal.pmed.1001509
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER:
http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001509
Contact:
Bertran Auvert
University of Versailles - INSERM
FRANCE
+33 6 03135159
bertran.auvert@uvsq.fr
Roll-out of community voluntary male circumcision is linked to reduced HIV infection levels
2013-09-04
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