(Press-News.org) Raleigh-Durham, NC. -- A new meta-analysis of 29 randomized studies involving more than 4,500 patients with knee osteoarthritis (OA) found that intra-articular hyaluronic acid (HA) injections provided significant improvement in pain and function compared to saline injections.
The study, "US-Approved Intra-Articular Hyaluronic Acid Injections are Safe and Effective in Patients with Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized, Saline-Controlled Trials," was published online this month in Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders and included results from randomized peer-reviewed studies of six HA injection brands, with identical treatment follow up between the treatment and control groups. The results are in contrast to the Rutjes et al (2012) paper that included data from many HA products which are not FDA approved and not available in the U.S.
"The findings of the meta-analysis are important but not unexpected. The safety data in the meta-analysis comes from studies that only used FDA-approved HAs. The data set is consistent with what I and many other physicians have clinically observed for many years – HAs have been found to be safe, can help relieve knee pain from osteoarthritis, and are appropriate treatment for people with mild to moderate forms of the disease," said Mark A. Snyder, MD, an orthopedic surgeon from the TriHealth Orthopedic and Spine Institute in Cincinnati, Ohio.
While neither HA or saline injections resulted in serious adverse events, researchers found very large treatment effects between four and 26 weeks for knee pain and function compared to pre-injection values, with standardized mean difference (SMD) values ranging from 1.07 to 1.37 (p END
Study upholds hyaluronic acid injection safety, efficacy profile in reducing knee OA pain
New meta-analysis findings challenge conclusions of recent reviews, confirms evidence that FDA-approved hyaluronic acid injections can help improve function and pain in mild to moderate knee osteoarthritis
2013-09-17
ELSE PRESS RELEASES FROM THIS DATE:
Carbonation alters the mind's perception of sweetness
2013-09-17
Bethesda, MD -- Carbonation, an essential component of popular soft drinks, alters the brain's perception of sweetness and makes it difficult for the brain to determine the difference between sugar and artificial sweeteners, according to a new article in Gastroenterology, the official journal of the American Gastroenterological Association.
"This study proves that the right combination of carbonation and artificial sweeteners can leave the sweet taste of diet drinks indistinguishable from normal drinks," said study author, Rosario Cuomo, associate professor, gastroenterology, ...
Racism linked to depression and anxiety in youth
2013-09-17
The first of its kind, the review showed 461 cases of links between racism and child and youth health outcomes.
Lead researcher Dr Naomi Priest at the McCaughey VicHealth Centre for Community Wellbeing at the University of Melbourne said the review demonstrated racism as an important factor influencing the health and wellbeing of children and youth.
"The review showed there are strong and consistent relationships between racial discrimination and a range of detrimental health outcomes such as low self-esteem, reduced resilience, increased behaviour problems and lower ...
Mt. Zion dig reveals possible second temple period priestly mansion
2013-09-17
In excavating sites in a long-inhabited urban area like Jerusalem, archaeologists are accustomed to noting complexity in their finds -- how various occupying civilizations layer over one another during the site's continuous use over millennia. But when an area has also been abandoned for intermittent periods, paradoxically there may be even richer finds uncovered, as some layers have been buried and remainundisturbed by development.
Such appears be the case at an archaeological dig on Jerusalem's Mount Zion, conducted by the University of North Carolina at Charlotte, ...
National Heart Centre Singapore discovers patient-specific cure for dangerous heart rhythm disorder
2013-09-17
The National Heart Centre Singapore (NHCS) research team has successfully and completely reversed the effects of the hERG (human ether-a-go-go-related gene) mutation in long QT syndrome 2 (LQTS 2) in patient-specific heart cells, scoring a world's first. Long QT syndrome 2 is a dangerous heart rhythm disorder that can lead to sudden cardiac death, even in young patients. It is caused by a mutation in a specific gene known as hERG, which helps to control the electrical activity in the heart cells and coordinate its beating rhythm. Using the patient's own skin stem cells ...
Digestive disorder reaches record levels in Scots children
2013-09-17
More children than ever before are living with a debilitating digestive disease, research has shown.
Scientists have found that coeliac disease affects six times more children living in Scotland now than it did in 1990.
A team from the University of Edinburgh and Queen Margaret University analysed the health records of children from South East Scotland aged under 16 years who were newly diagnosed with the condition between 1990 and 2009.
The team – based at Royal Hospital for Sick Children in Edinburgh – found that the rate of children being newly diagnosed with Coeliac ...
Virginia Tech researchers help people in remote Africa respond to diarrheal disease
2013-09-17
Using a simple survey tool, a team of researchers has done what complex studies have failed to do -- provide data that identifies starting points for preventing diarrheal disease outbreaks in at least one region of Africa.
Diarrheal illness is a leading cause of disease and death in children under 5, and in HIV-plagued Botswana, it is a significant issue for those over 5 as well.
"Yet we still know little about the dynamics of this illness and other infectious diseases," said disease ecologist Kathleen Alexander, an associate professor of wildlife in the College of ...
In patients with acute cholecystitis, surgery should be performed immediately
2013-09-17
Should surgery be performed immediately, or is it better to first administer antibiotics and then perform surgery? A study led by Heidelberg University Hospital Department of Surgery has demonstrated that patients suffering from acute cholecystitis should be operated on immediately. There are no advantages to delaying surgery until antibiotic therapy has been administered for several weeks. After undergoing surgery performed within 24 hours of diagnosis, the patients have fewer complications, are back on their feet earlier, and can leave the hospital more quickly. "With ...
First-time measurements in Greenland snowpack show a drop in atmospheric co since 1950s
2013-09-17
A first-ever study of air trapped in the deep snowpack of Greenland shows that atmospheric levels of carbon monoxide (CO) in the 1950s were actually slightly higher than what we have today. This is a surprise because current computer models predict much higher CO concentrations over Greenland today than in 1950. Now it appears the opposite is in fact true.
In a paper recently published in the journal Atmospheric Chemistry and Physics, Vasilii Petrenko, an assistant professor of earth and environmental sciences, concluded that CO levels rose slightly from 1950 until the ...
Environmental complexity promotes biodiversity
2013-09-17
The study, led by McGill University evolutionary biologist Ben Haller in collaboration with IIASA Evolution and Ecology Program Leader Ulf Dieckmann and IIASA researcher Rupert Mazzucco, suggests that a varied environment spurs the evolution of new species and promotes biodiversity by creating places of refuge—"refugia"—for new organisms to evolve.
The model represents asexual organisms that reproduce like plants. To investigate how environmental variation affects evolution, Haller modeled an environment with complex spatial structure. "We wanted to look at more realistic ...
Mesenchymal stem cell transplantation may heal a mother's childbirth injury
2013-09-17
Putnam Valley, NY. (Sept. 17 2013) – Vaginal delivery presents the possibility of injury for mothers that can lead to "stress urinary incontinence" (SUI), a condition affecting from four to 35 percent of women who have had babies via vaginal delivery. Many current treatments, such as physiotherapy and surgery, are not very effective.
Seeking better methods to alleviate SUI, researchers carried out a study in which female laboratory rats modeled with simulated childbirth injuries received injections of mesenchymal stem cells (MSCs; multipotent cells found in connective ...
LAST 30 PRESS RELEASES:
Keeping pediatrics afloat in a sea of funding cuts
Giant resistivity reduction in thin film a key step towards next-gen electronics for AI
First pregnancy with AI-guided sperm recovery method developed at Columbia
Global study reveals how bacteria shape the health of lakes and reservoirs
Biochar reimagined: Scientists unlock record-breaking strength in wood-derived carbon
Synthesis of seven quebracho indole alkaloids using "antenna ligands" in 7-10 steps, including three first-ever asymmetric syntheses
BioOne and Max Planck Society sign 3-year agreement to include subscribe to open pilot
How the arts and science can jointly protect nature
Student's unexpected rise as a researcher leads to critical new insights into HPV
Ominous false alarm in the kidney
MSK Research Highlights, October 31, 2025
Lisbon to host world’s largest conference on ecosystem restoration in 2027, led by researcher from the Faculty of Sciences, University of Lisbon
Electrocatalysis with dual functionality – an overview
Scripps Research awarded $6.9 million by NIH to crack the code of lasting HIV vaccine protection
New post-hoc analysis shows patients whose clinicians had access to GeneSight results for depression treatment are more likely to feel better sooner
First transplant in pigs of modified porcine kidneys with human renal organoids
Reinforcement learning and blockchain: new strategies to secure the Internet of Medical Things
Autograph: A higher-accuracy and faster framework for compute-intensive programs
Expansion microscopy helps chart the planktonic universe
Small bat hunts like lions – only better
As Medicaid work requirements loom, U-M study finds links between coverage, better health and higher employment
Manifestations of structural racism and inequities in cardiovascular health across US neighborhoods
Prescribing trends of glucagon-like peptide 1 receptor agonists for type 2 diabetes or obesity
Continuous glucose monitoring frequency and glycemic control in people with type 2 diabetes
Bimodal tactile tomography with bayesian sequential palpation for intracavitary microstructure profiling and segmentation
IEEE study reviews novel photonics breakthroughs of 2024
New method for intentional control of bionic prostheses
Obesity treatment risks becoming a ‘two-tier system’, researchers warn
Researchers discuss gaps, obstacles and solutions for contraception
Disrupted connectivity of the brainstem ascending reticular activating system nuclei-left parahippocampal gyrus could reveal mechanisms of delirium following basal ganglia intracerebral hemorrhage
[Press-News.org] Study upholds hyaluronic acid injection safety, efficacy profile in reducing knee OA painNew meta-analysis findings challenge conclusions of recent reviews, confirms evidence that FDA-approved hyaluronic acid injections can help improve function and pain in mild to moderate knee osteoarthritis