Addiction: Can you ever really completely leave it behind?

A new study in Biological Psychiatry suggests the answer is no

2013-09-23

(Press-News.org) Philadelphia, PA, September 23, 2013 – It is often said that once people develop an addiction, they can never completely eliminate their attraction to the abused substance. New findings provide further support for this notion by suggesting that even long-term abstinence from cocaine does not result in a complete normalization of brain circuitry.

Scientists are currently trying to answer some of the 'chicken and egg' questions surrounding the abuse of drugs. In particular, one of those questions is whether individuals who abuse psychostimulants like cocaine are more impulsive and show alterations in brain reward circuits as a consequence of using the drug, or whether such abnormalities existed prior to their drug use. In the former case, one might expect brain alterations to normalize following prolonged drug abstinence.

To address these questions, Krishna Patel at Institute of Living/Hartford Hospital and colleagues compared neural responses between three groups of people who were asked to complete a task that resembles bidding on eBay items. The 3 groups consisted of 47 healthy controls, 42 currently drug-abusing cocaine users, and 35 former cocaine users who had been abstinent an average of 4 years. They also compared all three groups on their levels of impulsivity and reward responding.

They found that active users showed abnormal activation in multiple brain regions involved with reward processing, and that the abstinent individuals who were previously cocaine dependent manifested differences in a subset of those regions. Both current and former cocaine users displayed similarly elevated impulsivity measures compared to healthy controls, which may indicate that these individuals had a pre-existing risk for addiction. Indeed, the degree of impulsivity correlated with several of the brain activation abnormalities.

These findings suggest that prolonged abstinence from cocaine may normalize only a subset of the brain abnormalities associated with active drug use.

"The knowledge that some neural changes associated with addiction persist despite long periods of abstinence is important because it supports clinical wisdom that recovery from addiction is a lifelong process," says Dr. John Krystal, Editor of Biological Psychiatry. "Further, it is the start of a deeper question: How do these persisting changes develop and how can they be reversed?"

The authors agree that further studies will be needed to investigate such questions, including the continued attempt to determine the extent to which differences in former cocaine users reflect aspects of pre-existing features, exposure to cocaine, or recovery.

### The article is "Robust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task" by Krishna T. Patel, Michael C. Stevens, Shashwath A. Meda, Christine Muska, Andre D. Thomas, Marc N. Potenza, and Godfrey D. Pearlson (doi: 10.1016/j.biopsych.2013.04.029). The article appears in Biological Psychiatry, Volume 74, Issue 7 (October 1, 2013), published by Elsevier.

Notes for editors Full text of the article is available to credentialed journalists upon request; contact Rhiannon Bugno at +1 214 648 0880 or Biol.Psych@utsouthwestern.edu. Journalists wishing to interview the authors may contact Krishna Patel at +1 860 545 7032 or krishna.pancholi@hhchealth.org.

The authors' affiliations, and disclosures of financial and conflicts of interests are available in the article.

John H. Krystal, M.D., is Chairman of the Department of Psychiatry at the Yale University School of Medicine and a research psychiatrist at the VA Connecticut Healthcare System. His disclosures of financial and conflicts of interests are available here.

About Biological Psychiatry Biological Psychiatry is the official journal of the Society of Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal publishes both basic and clinical contributions from all disciplines and research areas relevant to the pathophysiology and treatment of major psychiatric disorders.

The journal publishes novel results of original research which represent an important new lead or significant impact on the field, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. Reviews and commentaries that focus on topics of current research and interest are also encouraged.

Biological Psychiatry is one of the most selective and highly cited journals in the field of psychiatric neuroscience. It is ranked 4th out of 135 Psychiatry titles and 13th out of 251 Neurosciences titles in the Journal Citations Reports® published by Thomson Reuters. The 2012 Impact Factor score for Biological Psychiatry is 9.247.

About Elsevier Elsevier is a world-leading provider of scientific, technical and medical information products and services. The company works in partnership with the global science and health communities to publish more than 2,000 journals, including The Lancet and Cell, and close to 20,000 book titles, including major reference works from Mosby and Saunders. Elsevier's online solutions include ScienceDirect, Scopus, SciVal, Reaxys, ClinicalKey and Mosby's Suite, which enhance the productivity of science and health professionals, helping research and health care institutions deliver better outcomes more cost-effectively.

A global business headquartered in Amsterdam, Elsevier employs 7,000 people worldwide. The company is part of Reed Elsevier Group plc, a world leading provider of professional information solutions. The group employs more than 30,000 people, including more than 15,000 in North America. Reed Elsevier Group plc is owned equally by two parent companies, Reed Elsevier PLC and Reed Elsevier NV. Their shares are traded on the London, Amsterdam and New York Stock Exchanges using the following ticker symbols: London: REL; Amsterdam: REN; New York: RUK and ENL.

ELSE PRESS RELEASES FROM THIS DATE:

U of M research uncovers gene's contribution to asthma susceptibility

2013-09-23

MINNEAPOLIS/ST. PAUL (09/23/2013) -- New research from the University of Minnesota College of Veterinary Medicine (CVM) has uncovered the role gene ORMDL3 plays in the disease asthma. ORMDL3, a gene recently linked to asthma susceptibility, has now been linked to the body's ability to recruit inflammatory cells during an airway allergic reaction. Study findings appear today in the journal Nature Communications. U of M researchers including Srirama Rao, Ph.D., (P. Sriramarao), CVM professor in the Department of Veterinary and Biomedical Sciences and associate dean for ...

CDC, Mass. General study reveals that preventing malaria in travelers to West Africa reduces health costs

2013-09-23

Not only do U.S. travelers to West Africa who consult health providers before they leave and take prescribed preventive medications substantially reduce their risk of contracting malaria, they also reduce costs to their health insurance providers and, in most cases, to themselves. In a report that has been published online in Clinical Infectious Disease, researchers from the U.S. Centers for Disease Control and Prevention (CDC) and from Massachusetts General Hospital (MGH) report finding that the costs associated with contracting malaria -- to both third-party payers and ...

Chasing the black holes of the ocean

2013-09-23

This news release is available in German. The mild winters experienced in Northern Europe are thanks to the Gulf Stream, which makes up part of those ocean currents spanning the globe that impact on the climate. However, our climate is also influenced by huge eddies of over 150 kilometres in diameter that rotate and drift across the ocean. Their number is reportedly on the rise in the Southern Ocean, increasing the northward transport of warm and salty water. Intriguingly, this could moderate the negative impact of melting sea ice in a warming climate. However, ...

Appropriate vaccinations schedules for feline patients outlined

2013-09-23

The Feline Vaccination Advisory Panel of the American Association of Feline Practitioners (AAFP) issue new guidelines on vaccination schedules for feline patients based on risk assessment. From Journal of Feline Medicine and Surgery (2013) The American Association of Feline Practitioners' (AAFP) Feline Vaccination Advisory Panel has this month released updated guidelines on appropriate feline vaccination schedules based on risk assessment. The guidelines offer recommendations for vaccination of household pet cats, shelter house cats, and cats in breeding catteries. ...

Bacteria don't always work 'just in time'

2013-09-23

Jena (Germany) 'Just in time' – not only cars are being built according to this principle nowadays. Aircraft, mobile phones and computers are also produced following this method, in which all components are delivered exactly at the time when they are needed. This saves storage capacity and therefore cash. Hence it is supposed to be particularly efficient. In nature – the byword for efficiency – production processes are also following the 'just-in-time-principle' as well – at least according to the scientific consensus until now. "Living beings just can't afford to produce ...

A fast fish with a huge impact

2013-09-23

Recent decades have seen massive changes to many river systems. To improve passage for ships, humans have been straightening, deepening, and reinforcing river banks and altered the natural flow regime. Water temperatures are also rising as a result of climate change. All of which provides perfect conditions for the round goby, a fish traditionally found in the lower stretches of the Danube and along the coasts of the Black Sea. Today, however, round goby has expanded its distribution range significantly and can now be found in the headwater of the Danube as well as in the ...

Some parts of memory still developing deep into childhood

2013-09-23

COLUMBUS, Ohio – A new study provides evidence that one important part of memory undergoes substantial development even after the age of 7. Researchers found that episodic memory – the ability to remember not only what happened, but where and when – takes longer to develop than often assumed. That means young children may have no problem with remembering certain simple events or facts. But in some cases, they may have difficulty placing them in the right place, time or context. The results have widespread implications, including what young children can be expected ...

Domain walls as new information storage medium

2013-09-23

While searching for ever smaller devices that can be used as data storage systems and novel sensors, physicists at Johannes Gutenberg University Mainz (JGU) have directly observed magnetization dynamics processes in magnetic nanowires and thus paved the way for further research in the field of nanomagnetism. Small magnetic domain wall structures in nanowires can be used to store information and, for example, can be used as angle sensors. Initial applications based on magnetic domain walls have been developed and are already in use in sensor technology. The current findings ...

First steps towards achieving better and cheaper biodiesel

2013-09-23

This news release is available in Spanish. Is there any connection between wine and biodiesel? The answer is yes, however surprising it may seem. Acetals are chemical compounds found in many wines, like port, for example, which give it a unique, sweet smell. However if acetals are blended with biodiesel, they improve its properties. The SUPREN research group of the Department of Chemical Engineering and the Environment of the Faculty of Engineering in Bilbao (UPV/EHU) is working on a project that is seeking to encourage the use of this rare fuel. The idea is to produce ...

Researchers probe the optical properties of a novel kind of magnetism

2013-09-23

CAMBRIDGE, Mass-- Using low-frequency laser pulses, a team of researchers has carried out the first measurements that reveal the detailed characteristics of a unique kind of magnetism found in a mineral called herbertsmithite. In this material, the magnetic elements constantly fluctuate, leading to an exotic state of fluid magnetism called a "quantum spin liquid." This is in contrast to conventional magnetism, found in materials called ferromagnets — where all of the magnetic forces align in the same direction, reinforcing each other — or antiferromagnets, where adjacent ...

Addiction: Can you ever really completely leave it behind?

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: