PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Scientists shed light on the brain mechanisms behind a debilitating sleep disorder

Researchers at the University of Toronto discover how the body's muscles accidentally fall asleep while awake

2013-10-11
(Press-News.org) Normally muscles contract in order to support the body, but in a rare condition known as cataplexy the body's muscles "fall asleep" and become involuntarily paralyzed. Cataplexy is incapacitating because it leaves the affected individual awake, but either fully or partially paralyzed. It is one of the bizarre symptoms of the sleep disorder called narcolepsy.

"Cataplexy is characterized by muscle paralysis during cognitive awareness, but we didn't understand how this happened until now, said John Peever of the University of Toronto's Department of Cell & Systems Biology. "We have shown that the neuro-degeneration of the brain cells that synthesize the chemical hypocretin causes the noradrenaline system to malfunction. When the norandrenaline system stops working properly, it fails to keep the motor and cognitive systems coupled. This results in cataplexy – the muscles fall asleep but the brain stays awake."

Peever and Christian Burgess, also of Cell & Systems Biology used hypocretin-knockout mice (mice that experience cataplexy), to demonstate that a dysfunctional relationship between the noradrenaline system and the hypocretin-producing system is behind cataplexy. The research was recently published in the journal Current Biology in September.

The scientists first established that mice experienced sudden loss of muscle tone during cataplectic episodes. They then administered drugs to systematically inhibit or activate a particular subset of adrenergic receptors, the targets of noradrenaline. They were able to reduce the incidence of cataplexy by 90 per cent by activating noradrenaline receptors. In contrast, they found that inhibiting the same receptors increased the incidence of cataplexy by 92 per cent. Their next step was to successfully link how these changes affect the brain cells that directly control muscles.

They found that noradrenaline is responsible for keeping the brain cells (motoneurons) and muscles active. But during cataplexy when muscle tone falls, noradrenaline levels disappear. This forces the muscle to relax and causes paralysis during cataplexy. Peever and Burgess found that restoring noradrenaline pre-empted cataplexy, confirming that the noradrenaline system plays a key role.

INFORMATION:

CONTACT:

John Peever
Cell & Systems Biology
University of Toronto
Tel: 416-946-5564
Mobile: 647-207-7920
John.peever@utoronto.ca

Kim Luke
Communications, Faculty of Arts & Science
University of Toronto
416-978-4352
Kim.luke@utoronto.ca

END



ELSE PRESS RELEASES FROM THIS DATE:

Ancient DNA reveals multiple stages of settlement in Europe

2013-10-11
WASHINGTON—Research conducted by the National Geographic Genographic Project, a multiyear global initiative that uses DNA to map the history of human migration, is helping unravel the timing and source of human settlement in Central Europe. New ancient-DNA research led by the National Geographic Society's Genographic Project, the Australian Centre for Ancient DNA (ACAD) and researchers from the University of Mainz in Germany and the State Heritage Museum in Halle (Germany) showed a pattern of genetic replacement taking place across several millennia in a region of central ...

Unregulated, agricultural ammonia threatens national parks' ecology

2013-10-11
Cambridge, Mass. – October 10, 2013 – Thirty-eight U.S. national parks are experiencing "accidental fertilization" at or above a critical threshold for ecological damage, according to a study published in the journal Atmospheric Chemistry and Physics and led by Harvard University researchers. Unless significant controls on ammonia emissions are introduced at a national level, they say, little improvement is likely between now and 2050. The environmental scientists, experts in air quality, atmospheric chemistry, and ecology, have been studying the fate of nitrogen-based ...

Rice University mix of graphene nanoribbons, polymer has potential for cars, soda, beer

2013-10-11
A discovery at Rice University aims to make vehicles that run on compressed natural gas more practical. It might also prolong the shelf life of bottled beer and soda. The Rice lab of chemist James Tour has enhanced a polymer material to make it far more impermeable to pressurized gas and far lighter than the metal in tanks now used to contain the gas. The combination could be a boon for an auto industry under pressure to market consumer cars that use cheaper natural gas. It could also find a market in food and beverage packaging. Tour and his colleagues at Rice and ...

New device harnesses sun and sewage to produce hydrogen fuel

2013-10-11
A novel device that uses only sunlight and wastewater to produce hydrogen gas could provide a sustainable energy source while improving the efficiency of wastewater treatment. A research team led by Yat Li, associate professor of chemistry at the University of California, Santa Cruz, developed the solar-microbial device and reported their results in a paper published in the American Chemical Society journal ACS Nano. The hybrid device combines a microbial fuel cell (MFC) and a type of solar cell called a photoelectrochemical cell (PEC). In the MFC component, bacteria ...

How research ecologists can benefit urban design projects

2013-10-11
Ecologists conducting field research usually study areas that they hope won't be disturbed for a while. But in an article published in the November issue of BioScience, "Mapping the Design Process for Urban Ecology Researchers," Alexander Felson of Yale University and his colleagues describe how ecologists can perform hypothesis-driven research from the start of design through the construction and monitoring phases of major urban projects. The results from such "designed experiments" can provide site-specific data that improve how the projects are conceptualized, built ...

Well-child visits more likely when parents use online health tools

2013-10-11
HONOLULU, October 11, 2013 — Young children whose parents used an integrated personal health record were more likely to attend six or more of the nationally recommended well-child care visits by 15 months of age, according to a Kaiser Permanente study published today in The Journal of Pediatrics. Using any Web-enabled device, PHRs allow patients to view parts of their medical record, including immunizations and after-visit instructions, manage appointments, refill prescriptions, check lab results, and securely communicate with their health care providers. In this retrospective ...

Study: Herbal products omit ingredients, contain fillers

2013-10-11
Consumers of natural health products beware. The majority of herbal products on the market contain ingredients not listed on the label, with most companies substituting cheaper alternatives and using fillers, according to new research from the University of Guelph. The study, published today in the open access journal BMC Medicine, used DNA barcoding technology to test 44 herbal products sold by 12 companies. Only two of the companies provided authentic products without substitutions, contaminants or fillers. Overall, nearly 60 per cent of the herbal products contained ...

Healthier diets possible in low-income, rural communities in America

2013-10-11
Philadelphia, PA, October 11, 2013 – In the United States, children don't eat enough fruits, vegetables and whole grains. Instead, their diets typically include excessive amounts of sugars and solid fats, counter to the 2010 Dietary Guidelines for Americans recommendations, increasing the risk of obesity and diabetes. A team of investigators implemented a two-year intervention study in low-income, rural areas where a disproportionately higher risk of overweight and obesity habits among children persists, leading to increased risk of diabetes and heart disease in adulthood. ...

Med schools improve conflict-of-interest standards, yet much room for progress remains

2013-10-11
New York, NY— U.S. medical schools have made significant progress to strengthen their management of clinical conflicts of interest (CCOI), but a new study demonstrates that most schools still lag behind national standards. The Institute on Medicine as a Profession (IMAP) study, which compared changes in schools' policies in a dozen areas from 2008 to 2011, reveals that institutions are racing from the bottom to the middle, not to the top. In 2011, nearly two-thirds of medical schools still lacked policies to limit ties to industry in at least one area explored, including ...

US health spending projected to grow an average of 5.8 percent annually through 2022

2013-10-10
Bethesda, MD -- New estimates released 9/18/13 from the Office of the Actuary at the Centers for Medicare and Medicaid Services (CMS) project that aggregate health care spending in the United States will grow at an average annual rate of 5.8 percent for 2012-22, or 1.0 percentage point faster than the expected growth in the gross domestic product (GDP). The health care share of GDP by 2022 is projected to rise to 19.9 percent from its 2011 level of 17.9 percent. The findings appeared as a Health Affairs Web First article, which is published in the October issue. The article ...

LAST 30 PRESS RELEASES:

Sylvester Cancer Tip Sheet for October 2025

Three science and technology leaders elected to Hertz Foundation Board of Directors

Jump Trading CSO Kevin Bowers elected to Hertz Foundation Board of Directors

Former Inscripta CEO Sri Kosaraju elected to Hertz Foundation Board of Directors

Citadel’s Jordan Chetty elected to Hertz Foundation Board of Directors

McGill research flags Montreal snow dump, inactive landfills as major methane polluters

A lightweight and rapid bidirectional search algorithm

Eighty-five years of big tree history available in one place for the first time

MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery

Health and economic air quality co-benefits of stringent climate policies

How immune cells deliver their deadly cargo

How the brain becomes a better listener: How focus enhances sound processing

Processed fats found in margarines unlikely to affect heart health

Scientists discover how leukemia cells evade treatment

Sandra Shi MD, MPH, named 2025 STAT Wunderkind

Treating liver disease with microscopic nanoparticles

Chemicals might be hitching a ride on nanoplastics to enter your skin

Pregnant patients with preexisting high cholesterol may have elevated CV risk

UC stroke experts discuss current and future use of AI tools in research and treatment

The Southern Ocean’s low-salinity water locked away CO2 for decades, but...

OHSU researchers develop functional eggs from human skin cells

Most users cannot identify AI bias, even in training data

Hurricane outages: Analysis details the where, and who, of increased future power cuts

Craters on surface of melanoma cells found to serve as sites for tumor killing

Research Spotlight: Mapping overlooked challenges in stroke recovery

Geographic and temporal patterns of screening for breast, cervical, and colorectal cancer in the US

Cannabis laws and opioid use among commercially insured patients with cancer diagnoses

Research Spotlight: Surprising gene mutation in brain’s immune cells linked to increased Alzheimer’s risk

Missing molecule may explain Down syndrome

Donor diabetes and 1-year Descemet membrane endothelial keratoplasty success rate

[Press-News.org] Scientists shed light on the brain mechanisms behind a debilitating sleep disorder
Researchers at the University of Toronto discover how the body's muscles accidentally fall asleep while awake